A5063712117- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Alcohol Consumption and Health Effects
- Cardiac Health and Mental Health
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Health and Disease Prevention
- Gout, Hyperuricemia, Uric Acid
- Magnesium in Health and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Parathyroid Disorders and Treatments
- Tryptophan and brain disorders
- Cardiovascular Effects of Exercise
- Trace Elements in Health
- Lipoproteins and Cardiovascular Health
- Blood Pressure and Hypertension Studies
- Cardiovascular and exercise physiology
- Potassium and Related Disorders
- Workplace Health and Well-being
- Advanced Neuroimaging Techniques and Applications
- COVID-19 Clinical Research Studies
- Cardiovascular Disease and Adiposity
- Heart Rate Variability and Autonomic Control
Emory University
2019-2024
Carleton University
2023
Background Polypharmacy is highly prevalent in elderly people with chronic conditions, including atrial fibrillation (AF). The impact of polypharmacy on adverse outcomes and treatment effectiveness patients AF remains unaddressed. Methods Results We studied 338 810 ≥75 years age enrolled the MarketScan Medicare Supplemental database 2007-2015. was defined as ≥5 active prescriptions at diagnosis (defined by presence International Classification Diseases, Ninth Revision, Clinical Modification...
The prevalence, incidence and risk factors of atrial fibrillation (AF) in a large, geographically ethnically diverse cohort the United States have not been fully described.
Higher serum magnesium is associated with lower risk of multiple morbidities, including diabetes, stroke, and atrial fibrillation, but its potential neuroprotective properties have also been gaining traction in cognitive function decline research. We studied 12,040 participants presumed free dementia the Atherosclerosis Risk Communities (ARIC) study. Serum was measured fasting blood samples collected 1990–1992. Dementia status ascertained through examinations 2011–2013, 2016–2017, 2018–2019,...
Excessive alcohol consumption has been associated with increased risk of atrial fibrillation, although the underlying mechanisms remain unclear. An enlarged left atrium and impaired function may lead to fibrillation. The association structural functional measures, however, received limited attention.
To examine the cross-sectional associations of individual measures SES-educational attainment and household income-and joint effects SES with PWV, as well SES-race interaction, in a cohort older African American White adults.
Contemporary use of sodium-glucose cotransporter-2 inhibitors (SGLT2i) and angiotensin receptor-neprilysin (ARNi) in patients with atrial fibrillation (AF) heart failure (HF) has not been described.
Background Outcomes among atrial fibrillation (AF) patients may differ according to race/ethnicity and sex due differences in biology, the prevalence of cardiovascular risk factors, use effectiveness AF treatments. We aimed characterize patterns across subgroups by race/ethnicity, since doing so provide opportunities identify interventions. also evaluated whether these changed over time. Methods utilized administrative claims data from Optum Clinformatics® Datamart database 2009 2015....
Abstract Aims To evaluate the association of physical activity (PA) with atrial fibrillation (AF) incidence in an elderly population. Methods We studied 5166 participants Atherosclerosis Risk Communities cohort examined 2011–2013 free AF. Self-reported PA was evaluated a validated questionnaire. Weekly minutes leisure-time moderate to vigorous (MVPA) were calculated and categorized using 2018 Physical Activity Guidelines for Americans (no [0 min/week], low [> 0– < 150 adequate [150–...
Background Atrial fibrillation (AF) increases the risk of stroke and extracranial systemic embolic events (SEEs), but little is known about magnitude association AF with SEE. Methods Results This analysis included 14 941 participants ARIC (Atherosclerosis Risk in Communities) study (mean age, 54.2±5.8, 55% women, 74% White) without at baseline (1987-1989) followed through 2017. was identified from ECGs, hospital discharges, death certificates, while SEEs were ascertained discharges....
Circulating magnesium has been associated with a lower risk of dementia, but the physiologic effects by which may prevent neurological insults remain unclear. We studied 1466 individuals (mean age 76.2 ± 5.3, 28.8% black, 60.1% female) free prevalent stroke, measured serum and available MRI scans obtained in 2011-2013, participating Atherosclerosis Risk Communities Neurocognitive Study (ARIC-NCS). Cross-sectional differences frontal, temporal, parietal, occipital lobe volume, along deep grey...
Atrial fibrillation (AF) is linked to increased risk of dementia and cognitive decline, but whether AF its ascertainment methods affect cognition in patients with hypertension has received less attention. We studied 8469 participants elevated systolic blood pressure who were free stroke diabetes at baseline enrolled the Systolic Blood Pressure Intervention Trial. was ascertained using three approaches: self-report AF, from a safety event, study electrocardiogram-determined (ECG) AF. Mild...
ABSTRACT Objective To evaluate utilization of sodium-glucose cotransporter-2 inhibitors (SGLT2i) and angiotensin receptor neprilysin (ARNi) in patients with atrial fibrillation (AF) heart failure (HF). Methods We analyzed the MarketScan databases for period 1/1/2021 to 6/30/2022. Validated algorithms were used identify AF HF, classify into HF reduced ejection fraction (HFrEF) or preserved (HFpEF). assessed prevalence SGLT2i ARNi use overall by type. Additionally, we explored correlates lower...
ABSTRACT Background Outcomes among atrial fibrillation (AF) patients may differ according to race/ethnicity and sex due differences in biology, the prevalence of cardiovascular risk factors, use effectiveness AF treatments. We aimed characterize patterns across subgroups by race/ethnicity, since doing so provide opportunities identify interventions. also evaluated whether these changed over time. Methods utilized administrative claims data from Optum Clinformatics® Datamart database 2009...
Abstract Long-chain sphingomyelins (SMs) may play an important role in the stability of myelin sheath underlying physical function. The objective this study was to examine cross-sectional and longitudinal associations long-chain SMs [SM (41:1), SM (41:2), (43:1)] ceramides [Cer (41:1) Cer with function Atherosclerosis Risk Communities (ARIC) study. Plasma concentrations (43:1), (43:1) were measured 389 ARIC participants 2011–13. Physical assessed by grip strength, Short Performance Battery...
ABSTRACT Background Excessive alcohol consumption has been associated with increased risk of atrial fibrillation, though the underlying mechanisms remain unclear. An enlarged left atrium and impaired function may lead to fibrillation. The association structural functional measures, however, received limited attention. Methods We studied a subset 515 participants from PREDIMED-Plus trial, Spanish ongoing, multi-center randomized trial testing an intensive life weight loss intervention (ILI)...
Atrial fibrillation (AF) is a common cardiac arrhythmia affecting over 6 million people in the U.S. Fatigue frequent symptom of AF, yet no underlying biological mechanisms have been identified AF-related fatigue as other chronic conditions such cancer or HIV (inflammation, tissue injury). We aimed to identify biomarkers and correlates AF-fatigue ARIC participants.
Background: Polypharmacy is highly prevalent in elderly individuals with chronic conditions, including atrial fibrillation (AF). The impact of polypharmacy on adverse outcomes and treatment effectiveness AF patients remains unaddressed. Methods: We studied 338,810 ≥75 years age 1,761,660 active prescriptions [mean (SD), 5.1 (3.8) per patient] enrolled the MarketScan Medicare Supplemental database 2007-2015. was defined as ≥5 at diagnosis based outpatient pharmacy claims. treatments (oral...
This paper explores how cultural factors impact the password-sharing attitudes and practices of young Bangladeshi adults.We conducted semi-structured interviews with 24 participants aged between 18 39 about how, why, whom they share passwords.Using Grounded Theory, we identified three stages password sharing (motivations, expectations, problems) (gender identity, collectivist social norms, religious identity) that in Bangladesh.We found is pervasive, deeply affected by culture identity.Young...
ABSTRACT Background The effect of alcohol consumption on cardiovascular health, including atrial fibrillation risk, remains controversial. Evaluating the association with circulating fibrillation-related biomarkers may help better understand relevant mechanistic underpinnings. Methods We studied 523 participants from 3 sites for PREDIMED-Plus study, a weight-loss randomized intervention trial in metabolically unhealthy adults. N-terminal pro-B-type natriuretic protein (NTproBNP), high...
Background: Recent studies have investigated the involvement of serum uric acid (SUA) in progression cognitive decline and dementia with conflicting results. SUA is known to be associated hypertension, inflammation, other cardiovascular risk factors, which often contribute dementia-like morbidity, yet several cross-sectional suggested that its antioxidant properties may protective against decline. Hypothesis: We hypothesized lower levels at baseline would an increased incident dementia....
Objectives: Embolic stroke is a major complication of atrial fibrillation (AF). Mechanisms that lead to elevated risk in AF are also likely increase extracranial systemic embolic events (SEE). However, little known about the magnitude association with SEE, needed fully characterize impact on cardiovascular outcomes. We evaluated SEE and prediction among persons community-based cohort. Methods: included 14,941 participants ARIC study (mean age, 54 ± 6, 55% women, 74% white) without at...