Valle Gómez
A5112233574- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Blood disorders and treatments
- Hemoglobinopathies and Related Disorders
- Business, Innovation, and Economy
- Lung Cancer Treatments and Mutations
- Hematopoietic Stem Cell Transplantation
- Retinoids in leukemia and cellular processes
- Immunotherapy and Immune Responses
- Peroxisome Proliferator-Activated Receptors
- Ethics and bioethics in healthcare
- Estrogen and related hormone effects
- Higher Education and Sustainability
- Multiple Myeloma Research and Treatments
- Fungal Infections and Studies
- T-cell and B-cell Immunology
- Ethics in medical practice
- Counseling Practices and Supervision
- Genomic variations and chromosomal abnormalities
- Bone and Joint Diseases
- Knowledge Societies in the 21st Century
Newmarket Equine Hospital
2024
Baylor College of Medicine
2024
Hospital Universitario de La Princesa
2008-2023
National University Toribio Rodríguez de Mendoza
2021
Hospital Universitari i Politècnic La Fe
2010
Background The prognostic value of cytogenetic findings in chronic myelomonocytic leukemia is unclear. Our purpose was to evaluate the independent impact abnormalities a large series patients with included database Spanish Registry Myelodysplastic Syndromes.Design and Methods We studied 414 according WHO criteria successful conventional analysis at diagnosis. Different patient disease characteristics were examined by univariate multivariate methods establish their relationship overall...
(1) Background: Despite the prognostic improvements achieved with tyrosine kinase inhibitors (TKIs) in chronic myeloid leukemia (CML), a minority of patients still fail TKIs. The recent introduction asciminib may be promising option intolerant patients, as it is first-in-class inhibitor more selective mechanism action different from ATP-competitive inhibition that occurs Therefore, our goal was to analyze toxicities shown well study cross-toxicity previous (2) Methods: An observational,...
Thrombocytopenia is very common in myelodysplastic syndrome (MDS); however, its clinical impact low-risk patients remains controversial.The authors analyzed the incidence and prognostic significance of thrombocytopenia at diagnosis 2565 de novo MDS included Spanish Registry.Thrombocytopenia (platelet count <100 × 10(9) /L) was identified 842 (32.8%). Severe <30 observed 7.1% significantly associated with a higher-risk World Health Organization subtype (P = .026) intermediate-2/high-risk...
Background More than 50% of patients with myelodysplastic syndromes present cytogenetic aberrations at diagnosis. Partial or complete deletion the long arm chromosome 5 is most frequent abnormality. The aim this study was to apply fluorescence in situ hybridization 5q31 diagnosed de novo whom conventional banding cytogenetics had shown a normal karyotype, absence metaphases an abnormal karyotype without evidence del(5q).Design and Methods We performed 716 patients, divided into two groups:...
The infrequency of translocations in myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemias (CMML) makes their identification reporting interesting for the recognition recurrent ones genes involved these neoplasias. aims this study were to identify new associated with MDS CMML establish frequency a cohort 8,016 patients from Spanish Group database. karyotype was evaluable 5,654 (70%) patients. Among those, 2,014 (36%) had chromosomal abnormalities, including 213 (10%)...
Chromosomal translocations are rare in the myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia (CMML). With exception of t(3q), not explicitly considered cytogenetic classification IPSS‐R their impact on disease progression patient survival is unknown. The present study was aimed at determining prognostic context IPSS‐R. We evaluated 1,653 patients from Spanish Registry MDS diagnosed with or CMML an abnormal karyotype by conventional analysis. Translocations were identified...
The fungal infections remain an important problem in the allogeneic stem cell trasnsplantation (allo-SCT) setting and thus, anti-fungal prophylaxis is commonly used. antifungal drug should offer activity, at least against Candida Aspergillus spp., a good safety profile low probability interactions. Micafungin could theoretically fulfill these requisites. aim of study was to describe experience with micafungin as primary patients undergoing allo-SCT cohort Spanish centres, evaluate its...
Peroxisomal biogenesis disorders (PBD) are autosomal recessive caused by loss-of-function mutations of one the