Xingyi Lu

ORCID: 0009-0007-0976-4655
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About
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Research Areas
  • Oral microbiology and periodontitis research
  • Probiotics and Fermented Foods
  • Gut microbiota and health
  • Dental Health and Care Utilization
  • Salivary Gland Disorders and Functions
  • Pediatric health and respiratory diseases
  • Digestive system and related health
  • Cleft Lip and Palate Research
  • Metabolomics and Mass Spectrometry Studies

University of Rochester Medical Center
2023-2025

Eastman Chemical Company (United States)
2024-2025

Eastman Dental Hospital
2025

Objective: This study aimed to identify the salivary levels of six hormones (progesterone, estradiol, testosterone, cortisol, thyroxine T3, and triiodothyronine T4) in pregnant women, assess association between hormones, dental caries, cariogenic microorganisms. Methods: cross-sectional included 181 low-income US women who were their third trimester. Demographic details, oral hygiene practices, medical backgrounds obtained via questionnaires records. Calibrated dentists data on plaque index...

10.3390/jcm13113183 article EN Journal of Clinical Medicine 2024-05-29

<title>Abstract</title> <bold>Objectives: </bold>This study aims to assess levels of salivary immune markers in women during the 3rd trimester pregnancy and explores association between dental caries, as well oral carriage pathogens <italic>Candida albicans</italic> <italic>Streptococcus mutans.</italic> These organisms are known be associated with infectious diseases such caries candida infection. <bold>Methods</bold>: Pregnant from underserved background participated this (n = 181)....

10.21203/rs.3.rs-5968375/v1 preprint EN Research Square (Research Square) 2025-04-14

Recent studies highlight the potential of Saccharomyces species as probiotics due to their ability modulate microbial interactions and reduce cariogenic activity, yet underlying metabolic mechanisms remain unclear. This study investigates cross-kingdom effects boulardii cerevisiae on processes Streptococcus mutans Candida albicans using a metabolomics-based approach. Untargeted LC-MS/MS analysis was conducted assess metabolites in planktonic model, followed by metabolomic profiling pathway...

10.3390/jof11040325 article EN cc-by Journal of Fungi 2025-04-19

This study aims to assess levels of salivary immune markers in women during the 3rd trimester pregnancy and explores association between dental caries, as well oral carriage pathogens Candida albicans Streptococcus mutans. These organisms are known be associated with infectious diseases such caries candida infection. Methods: Pregnant from underserved background participated this (n = 181). Participants received a comprehensive examination by trained calibrated dentists. Levels 36...

10.1038/s41598-025-99692-4 article EN cc-by-nc-nd Scientific Reports 2025-05-06

Dental caries is one of the most common chronic diseases worldwide. Streptococcus mutans and Candida albicans are two major pathogens associated with dental caries. Several recent studies revealed that Lactobacillus plantarum inhibits S. C. in biofilms a rodent model The aim this study was to investigate dose-dependent effect L. against planktonic simulated high-caries-risk clinical condition. Mono-, dual-, multi-species models were utilized, five doses (ranging from 1.0 × 104 108 CFU/mL)....

10.3390/pathogens12060848 article EN cc-by Pathogens 2023-06-20

Ecological approaches can help to correct oral microbial dysbiosis and drive the advent persistence of a symbiotic microbiome, which benefits long-term dental caries control. The aim this study was investigate impact prebiotic Galacto-oligosaccharide (GOS) on growth probiotics L. plantarum 14,917 its effect inhibitory ability against Streptococcus mutans Candida albicans in an vitro model. Single-species screenings were conducted TSBYE broth with 1% glucose 1–5% GOS. Interaction experiments...

10.3390/nu15092017 article EN Nutrients 2023-04-22

Aim This study aimed to evaluate the maternal and infant oral health benefits from mothers receiving prenatal total rehabilitation (PTOR) before childbirth. Methods Building upon our previous investigation, in which 15 expectant received PTOR their third trimester, achieving a state of free disease prior delivery, we conducted follow-up monitor these newborns until they reached 2 years age. We assessed impact on health, utilization dental care during postpartum/early-life period, carriage...

10.3389/froh.2024.1443337 article EN cc-by Frontiers in Oral Health 2024-08-13
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