A5056687534- Oral microbiology and periodontitis research
- Dental Health and Care Utilization
- Antifungal resistance and susceptibility
- Probiotics and Fermented Foods
- Pneumocystis jirovecii pneumonia detection and treatment
- Salivary Gland Disorders and Functions
- Streptococcal Infections and Treatments
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- COVID-19 Clinical Research Studies
- Pneumonia and Respiratory Infections
- Medication Adherence and Compliance
- Tuberculosis Research and Epidemiology
- Viral Infections and Vectors
- Pharmaceutical Practices and Patient Outcomes
- Oral Health Pathology and Treatment
- Dental materials and restorations
- Cervical Cancer and HPV Research
- COVID-19 diagnosis using AI
- Microbial Metabolism and Applications
- HIV/AIDS oral health manifestations
- Enzyme Production and Characterization
- Oral health in cancer treatment
- Endodontics and Root Canal Treatments
- Heparin-Induced Thrombocytopenia and Thrombosis
University of Rochester Medical Center
2018-2024
Eastman Chemical Company (United States)
2018-2024
University of Rochester
2022-2023
Capital Medical University
2018-2023
Shenzhen International Travel Health Care Center
2015-2022
Jinyintan Hospital
2020-2022
North Sichuan Medical University
2018-2021
Eastman Chemical Company (Germany)
2021
Peking University
2014
Peking University Third Hospital
2014
Abstract Background Medication nonadherence is a significant public health problem as it contributes to poor clinical outcomes and increased healthcare costs. Older patients with multimorbidity polypharmacy often have low medication adherence. These also high prevalence of potentially inappropriate (PIM) use. Aim To explore risk factors related in older examine the association between PIM Method A multicenter cross-sectional study was conducted from May December 2019 16 tertiary hospitals 12...
Dental caries, an ecological dysbiosis of oral microflora, initiates from the virulent biofilms formed on tooth surfaces where cariogenic microorganisms metabolize dietary carbohydrates, producing acid that demineralizes enamel. Forming biofilms, Streptococcus mutans and Candida albicans are well-recognized emerging pathogens for dental caries. Recently, probiotics have demonstrated their potential in treating biofilm-related diseases, including However, limited studies assessed effect...
Probiotics interfere with pathogenic microorganisms or reinstate the natural microbiome. Streptococcus mutans and Candida albicans are well-known emerging bacteria/fungi for dental caries. In this study, three probiotic Lactobacilli strains (Lactobacillus plantarum 8014, L. 14917, Lactobacillus salivarius 11741) were tested on S. C. clinical isolates using a multispecies biofilm model simulating cariogenic conditions. The ten pairs of obtained from children severe early childhood Our study...
Despite the cariogenic role of Candida suggested from recent studies, oral acquisition in children at high risk for early childhood caries (ECC) and its association with bacteria Streptococcus mutans remain unclear. Although ECC disproportionately afflicts socioeconomically disadvantaged racial-minority children, microbiological studies focusing on underserved group are scarce. Our prospective cohort study examined colonization S. among 101 infants exclusively a low-income background first...
To examine the effect of Nystatin oral rinse on Candida species and Streptococcus mutans carriage.Twenty healthy adults with candidiasis participated in single-arm clinical trial received for 7 days, 4 applications/day, 600,000 International Units/application. Demographic-socioeconomic-oral-medical conditions were obtained. Salivary plaque assessed at baseline 1-week 3-month follow-ups. Twenty-four salivary cytokines assessed. albicans isolates underwent susceptibility test.Half participants...
Abstract Background Despite the well-documented associations between poor maternal oral health and increased risk for adverse birth outcomes dental caries in children after birth, prenatal care is under-utilized, especially among underserved population. In addition, Candida has recently been suggested as a potential culprit children’s caries, with evident contributions. Therefore, this study aimed to obtain epidemiological data on carriage cohort of US pregnant women, reveal factors...
Despite the well-documented health benefits of probiotic Saccharomyces, its application in oral has not been comprehensively assessed. Dental caries is a transmissible disease initiated by acid production cariogenic bacteria and yeast, such as Streptococcus mutans Candida albicans, on tooth enamel followed subsequent demineralization. Here, we investigated effect two Saccharomyces strains (Saccharomyces boulardii cerevisiae) S. mutans–C. albicans cross-kingdom interactions using planktonic...
Prolonged presence of viral nucleic acid was reported in certain patients with coronavirus disease 2019 (COVID-19), unclear clinical and epidemiological significance. We here described the characteristics 37 recovered COVID-19 prolonged RNA Wuhan, China. For those who had been discharged re-admitted, their close contacts outside hospital were traced evaluated. The median age 62 years (IQR 50, 68), 24 (64.9%) men. They common or severe COVID-19. With positive RT-PCR, most clinically stable,...
Lasers represent a promising method for implant decontamination, but evidence on surface changes and subsequent biofilm formation is limited. This study aimed to assess the effect of erbium-doped yttrium aluminum garnet (Er:YAG) laser treatment zirconia titanium discs, differences in as result alterations.A two-stage (in vitro vivo) experiment utilizing Er:YAG discs was performed. In vitro, alterations, roughness, elemental-material weight following were assessed using scanning electron...
Abstract Background Suboptimal maternal oral health during pregnancy is potentially associated with adverse birth outcomes and increased dental caries risks in children. This study aimed to assess the microbiome immune response following an innovative clinical regimen, Prenatal Total Oral Rehabilitation (PTOR), that fully restores women’s a “disease-free status” before delivery. Methods prospective cohort assessed 15 pregnant women at baseline 3 follow-up visits (1 week, 2 weeks, months)...
Dental caries is one of the most common chronic diseases worldwide. Streptococcus mutans and Candida albicans are two major pathogens associated with dental caries. Several recent studies revealed that Lactobacillus plantarum inhibits S. C. in biofilms a rodent model The aim this study was to investigate dose-dependent effect L. against planktonic simulated high-caries-risk clinical condition. Mono-, dual-, multi-species models were utilized, five doses (ranging from 1.0 × 104 108 CFU/mL)....
Retrospective cohort study.
Objective: Although mitis-salivarius-bacitracin (MSB) agar is a commonly used selective medium for detecting Streptococcus mutans in clinical studies, non-S. microorganisms are cultivatable on MSB agar. Since few studies have identified bacteria grown MSB, this study aimed to identify and differentiate MSB-grown from predente infants' oral cavity. Study design: The saliva 51 infants were plated agars. Bacteria colonies characterized based their morphology under direct visualization light...
The carriage of Candida albicans in children’s oral cavities is associated with a higher risk for early childhood caries, so controlling this fungus life essential preventing caries. In prospective cohort 41 mothers and their children from 0 to 2 years age, study addressed four main objectives: (1) Evaluate vitro the antifungal agent susceptibility isolates mother-child cohort; (2) compare between children; (3) assess longitudinal changes collected years; (4) detect mutations C. resistance...
Pregnancy initiates a temporary transition in the maternal physiological state, with shift oral microbiome and potential increase frequency of diseases. The risk disease is higher among populations Hispanic Black women those lower socioeconomic status (low SES), demonstrating need for intervention within these high-risk populations. To further our understanding pregnant women, we characterized 28 nonpregnant 179 low-SES during their third trimester living Rochester, New York. Unstimulated...
Despite well-documented health benefits of probiotics Saccharomyces, its application in oral has not been comprehensively assessed. Dental caries is a transmissible disease initiated by acid production cariogenic bacteria and yeast, such as Streptococcus mutans Candida albicans, on tooth enamel followed subsequent demineralization. Here, we investigated the effect two Saccharomyces strains (Saccharomyces boulardii, cerevisiae) S. mutans-C. albicans cross-kingdom interactions using planktonic...
To assess the oral health condition and microbial outcomes from receiving an innovative treatment regimen - Prenatal Total Oral Rehabilitation (PTOR). This prospective cohort study included 15 pregnant women in PTOR group who had a baseline visit before three follow-up visits (immediate after, 2 weeks months) after PTOR. A historical control of additional was matched separate based on propensity score. Along with demographic medical background, conditions perinatal literacy were assessed....
This study aimed to evaluate the impact of Nystatin oral rinse on salivary and supragingival microbiota in adults with candidiasis identify predictive factors related individuals' responses Nystatin. The trial involved twenty participants who used 600,000 International Units/application for seven days, four times a day, were followed up at one week three months after rinse. plaque microbiome assessed via 16S rDNA amplicon sequencing. Overall, microbiomes remained stable. However, among (53...
Abstract Objectives To examine the effect of nystatin oral rinse on Candida species and Streptococcus mutans carriage. Materials Methods Twenty healthy adults with candidiasis participated in single-arm clinical trial received Nystatin for 7 days, 4 applications/day, 600,000 International Units/application. Demographic-socioeconomic-oral-medical conditions were obtained. Salivary plaque assessed at baseline, 1-week 3-month follow-ups. Twenty-four salivary cytokines assessed. albicans...