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Koji Kawakami

ORCID: 0009-0007-1950-3133
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A5018328161
Research Areas
  • Cancer-related gene regulation
  • RNA modifications and cancer
  • Cancer, Lipids, and Metabolism
  • Epigenetics and DNA Methylation
  • Cancer, Hypoxia, and Metabolism
  • Synthesis of heterocyclic compounds
  • Macrophage Migration Inhibitory Factor
  • Complement system in diseases
  • Escherichia coli research studies
  • Tuberculosis Research and Epidemiology
  • Neonatal Health and Biochemistry

Keio University
 2024

 PRMT1 Sustains De Novo Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer
OPENALEX - Publications 
Takehiro Yamamoto Tetsu Hayashida Yohei Masugi Kiyotaka Oshikawa Noriyo Hayakawa and 25 more Mai Itoh Chiyoko Nishime Masami Suzuki Aiko Nagayama Yuko Kawai Takako Hishiki Tomomi Matsuura Yoshiko Naito Akiko Kubo Arisa Yamamoto Yujiro Yoshioka Tomokazu Kurahori Misa Nagasaka Minako Takizawa Naoharu Takano Koji Kawakami Michiie Sakamoto Masatoshi Wakui Takushi Yamamoto Yuko Kitagawa Yasuaki Kabe Kenichi Horisawa Atsushi Suzuki Masaki Matsumoto Makoto Suematsu

Abstract Triple-negative breast cancer (TNBC) chemoresistance hampers the ability to effectively treat patients. Identification of mechanisms driving can lead strategies improve treatment. Here, we revealed that protein arginine methyltransferase-1 (PRMT1) simultaneously methylates D-3-phosphoglycerate dehydrogenase (PHGDH), a critical enzyme in serine synthesis, and glycolytic enzymes PFKFB3 PKM2 TNBC cells. 13C metabolic flux analyses showed PRMT1-dependent methylation these three diverts...

10.1158/0008-5472.can-23-2266 article EN cc-by-nc-nd Cancer Research 2024-02-22
 Supplementary Methods and References from PRMT1 Sustains <i>De Novo</i> Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer
OPENALEX - Publications 
Takehiro Yamamoto Tetsu Hayashida Yohei Masugi Kiyotaka Oshikawa Noriyo Hayakawa and 25 more Mai Itoh Chiyoko Nishime Masami Suzuki Aiko Nagayama Yuko Kawai Takako Hishiki Tomomi Matsuura Yoshiko Naito Akiko Kubo Arisa Yamamoto Yujiro Yoshioka Tomokazu Kurahori Misa Nagasaka Minako Takizawa Naoharu Takano Koji Kawakami Michiie Sakamoto Masatoshi Wakui Takushi Yamamoto Yuko Kitagawa Yasuaki Kabe Kenichi Horisawa Atsushi Suzuki Masaki Matsumoto Makoto Suematsu

&lt;p&gt;Methods and References&lt;/p&gt;

10.1158/0008-5472.25515678 preprint EN cc-by 2024-04-01
 Supplementary Fig.S4 from PRMT1 Sustains <i>De Novo</i> Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer
OPENALEX - Publications 
Takehiro Yamamoto Tetsu Hayashida Yohei Masugi Kiyotaka Oshikawa Noriyo Hayakawa and 25 more Mai Itoh Chiyoko Nishime Masami Suzuki Aiko Nagayama Yuko Kawai Takako Hishiki Tomomi Matsuura Yoshiko Naito Akiko Kubo Arisa Yamamoto Yujiro Yoshioka Tomokazu Kurahori Misa Nagasaka Minako Takizawa Naoharu Takano Koji Kawakami Michiie Sakamoto Masatoshi Wakui Takushi Yamamoto Yuko Kitagawa Yasuaki Kabe Kenichi Horisawa Atsushi Suzuki Masaki Matsumoto Makoto Suematsu

&lt;p&gt;Fig.S4&lt;/p&gt;

10.1158/0008-5472.25515696.v1 preprint EN cc-by 2024-04-01
 Supplementary Fig.S8 from PRMT1 Sustains <i>De Novo</i> Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer
OPENALEX - Publications 
Takehiro Yamamoto Tetsu Hayashida Yohei Masugi Kiyotaka Oshikawa Noriyo Hayakawa and 25 more Mai Itoh Chiyoko Nishime Masami Suzuki Aiko Nagayama Yuko Kawai Takako Hishiki Tomomi Matsuura Yoshiko Naito Akiko Kubo Arisa Yamamoto Yujiro Yoshioka Tomokazu Kurahori Misa Nagasaka Minako Takizawa Naoharu Takano Koji Kawakami Michiie Sakamoto Masatoshi Wakui Takushi Yamamoto Yuko Kitagawa Yasuaki Kabe Kenichi Horisawa Atsushi Suzuki Masaki Matsumoto Makoto Suematsu

&lt;p&gt;Fig.S8&lt;/p&gt;

10.1158/0008-5472.25515684 preprint EN cc-by 2024-04-01
 Supplementary Fig.S12 from PRMT1 Sustains <i>De Novo</i> Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer
OPENALEX - Publications 
Takehiro Yamamoto Tetsu Hayashida Yohei Masugi Kiyotaka Oshikawa Noriyo Hayakawa and 25 more Mai Itoh Chiyoko Nishime Masami Suzuki Aiko Nagayama Yuko Kawai Takako Hishiki Tomomi Matsuura Yoshiko Naito Akiko Kubo Arisa Yamamoto Yujiro Yoshioka Tomokazu Kurahori Misa Nagasaka Minako Takizawa Naoharu Takano Koji Kawakami Michiie Sakamoto Masatoshi Wakui Takushi Yamamoto Yuko Kitagawa Yasuaki Kabe Kenichi Horisawa Atsushi Suzuki Masaki Matsumoto Makoto Suematsu

&lt;p&gt;Fig.S12&lt;/p&gt;

10.1158/0008-5472.25515738.v1 preprint EN cc-by 2024-04-01
 Supplementary Fig.S9 from PRMT1 Sustains <i>De Novo</i> Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer
OPENALEX - Publications 
Takehiro Yamamoto Tetsu Hayashida Yohei Masugi Kiyotaka Oshikawa Noriyo Hayakawa and 25 more Mai Itoh Chiyoko Nishime Masami Suzuki Aiko Nagayama Yuko Kawai Takako Hishiki Tomomi Matsuura Yoshiko Naito Akiko Kubo Arisa Yamamoto Yujiro Yoshioka Tomokazu Kurahori Misa Nagasaka Minako Takizawa Naoharu Takano Koji Kawakami Michiie Sakamoto Masatoshi Wakui Takushi Yamamoto Yuko Kitagawa Yasuaki Kabe Kenichi Horisawa Atsushi Suzuki Masaki Matsumoto Makoto Suematsu

&lt;p&gt;Fig.S9&lt;/p&gt;

10.1158/0008-5472.25515681 preprint EN cc-by 2024-04-01
 Supplementary Fig.S13 from PRMT1 Sustains <i>De Novo</i> Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer
OPENALEX - Publications 
Takehiro Yamamoto Tetsu Hayashida Yohei Masugi Kiyotaka Oshikawa Noriyo Hayakawa and 25 more Mai Itoh Chiyoko Nishime Masami Suzuki Aiko Nagayama Yuko Kawai Takako Hishiki Tomomi Matsuura Yoshiko Naito Akiko Kubo Arisa Yamamoto Yujiro Yoshioka Tomokazu Kurahori Misa Nagasaka Minako Takizawa Naoharu Takano Koji Kawakami Michiie Sakamoto Masatoshi Wakui Takushi Yamamoto Yuko Kitagawa Yasuaki Kabe Kenichi Horisawa Atsushi Suzuki Masaki Matsumoto Makoto Suematsu

&lt;p&gt;Fig.S13&lt;/p&gt;

10.1158/0008-5472.25515735 preprint EN cc-by 2024-04-01
 Supplementary Fig.S9 from PRMT1 Sustains <i>De Novo</i> Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer
OPENALEX - Publications 
Takehiro Yamamoto Tetsu Hayashida Yohei Masugi Kiyotaka Oshikawa Noriyo Hayakawa and 25 more Mai Itoh Chiyoko Nishime Masami Suzuki Aiko Nagayama Yuko Kawai Takako Hishiki Tomomi Matsuura Yoshiko Naito Akiko Kubo Arisa Yamamoto Yujiro Yoshioka Tomokazu Kurahori Misa Nagasaka Minako Takizawa Naoharu Takano Koji Kawakami Michiie Sakamoto Masatoshi Wakui Takushi Yamamoto Yuko Kitagawa Yasuaki Kabe Kenichi Horisawa Atsushi Suzuki Masaki Matsumoto Makoto Suematsu

&lt;p&gt;Fig.S9&lt;/p&gt;

10.1158/0008-5472.25515681.v1 preprint EN cc-by 2024-04-01
 Supplementary Fig.S21 from PRMT1 Sustains <i>De Novo</i> Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer
OPENALEX - Publications 
Takehiro Yamamoto Tetsu Hayashida Yohei Masugi Kiyotaka Oshikawa Noriyo Hayakawa and 25 more Mai Itoh Chiyoko Nishime Masami Suzuki Aiko Nagayama Yuko Kawai Takako Hishiki Tomomi Matsuura Yoshiko Naito Akiko Kubo Arisa Yamamoto Yujiro Yoshioka Tomokazu Kurahori Misa Nagasaka Minako Takizawa Naoharu Takano Koji Kawakami Michiie Sakamoto Masatoshi Wakui Takushi Yamamoto Yuko Kitagawa Yasuaki Kabe Kenichi Horisawa Atsushi Suzuki Masaki Matsumoto Makoto Suematsu

&lt;p&gt;Fig.S21&lt;/p&gt;

10.1158/0008-5472.25515702.v1 preprint EN cc-by 2024-04-01
 Supplementary Fig.S18 from PRMT1 Sustains <i>De Novo</i> Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer
OPENALEX - Publications 
Takehiro Yamamoto Tetsu Hayashida Yohei Masugi Kiyotaka Oshikawa Noriyo Hayakawa and 25 more Mai Itoh Chiyoko Nishime Masami Suzuki Aiko Nagayama Yuko Kawai Takako Hishiki Tomomi Matsuura Yoshiko Naito Akiko Kubo Arisa Yamamoto Yujiro Yoshioka Tomokazu Kurahori Misa Nagasaka Minako Takizawa Naoharu Takano Koji Kawakami Michiie Sakamoto Masatoshi Wakui Takushi Yamamoto Yuko Kitagawa Yasuaki Kabe Kenichi Horisawa Atsushi Suzuki Masaki Matsumoto Makoto Suematsu

&lt;p&gt;Fig.S18&lt;/p&gt;

10.1158/0008-5472.25515717 preprint EN cc-by 2024-04-01
 Supplementary Fig.S12 from PRMT1 Sustains <i>De Novo</i> Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer
OPENALEX - Publications 
Takehiro Yamamoto Tetsu Hayashida Yohei Masugi Kiyotaka Oshikawa Noriyo Hayakawa and 25 more Mai Itoh Chiyoko Nishime Masami Suzuki Aiko Nagayama Yuko Kawai Takako Hishiki Tomomi Matsuura Yoshiko Naito Akiko Kubo Arisa Yamamoto Yujiro Yoshioka Tomokazu Kurahori Misa Nagasaka Minako Takizawa Naoharu Takano Koji Kawakami Michiie Sakamoto Masatoshi Wakui Takushi Yamamoto Yuko Kitagawa Yasuaki Kabe Kenichi Horisawa Atsushi Suzuki Masaki Matsumoto Makoto Suematsu

&lt;p&gt;Fig.S12&lt;/p&gt;

10.1158/0008-5472.25515738 preprint EN cc-by 2024-04-01
 Supplementary Fig.S7 from PRMT1 Sustains <i>De Novo</i> Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer
OPENALEX - Publications 
Takehiro Yamamoto Tetsu Hayashida Yohei Masugi Kiyotaka Oshikawa Noriyo Hayakawa and 25 more Mai Itoh Chiyoko Nishime Masami Suzuki Aiko Nagayama Yuko Kawai Takako Hishiki Tomomi Matsuura Yoshiko Naito Akiko Kubo Arisa Yamamoto Yujiro Yoshioka Tomokazu Kurahori Misa Nagasaka Minako Takizawa Naoharu Takano Koji Kawakami Michiie Sakamoto Masatoshi Wakui Takushi Yamamoto Yuko Kitagawa Yasuaki Kabe Kenichi Horisawa Atsushi Suzuki Masaki Matsumoto Makoto Suematsu

&lt;p&gt;Fig.S7&lt;/p&gt;

10.1158/0008-5472.25515687 preprint EN cc-by 2024-04-01
 Supplementary Fig.S8 from PRMT1 Sustains <i>De Novo</i> Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer
OPENALEX - Publications 
Takehiro Yamamoto Tetsu Hayashida Yohei Masugi Kiyotaka Oshikawa Noriyo Hayakawa and 25 more Mai Itoh Chiyoko Nishime Masami Suzuki Aiko Nagayama Yuko Kawai Takako Hishiki Tomomi Matsuura Yoshiko Naito Akiko Kubo Arisa Yamamoto Yujiro Yoshioka Tomokazu Kurahori Misa Nagasaka Minako Takizawa Naoharu Takano Koji Kawakami Michiie Sakamoto Masatoshi Wakui Takushi Yamamoto Yuko Kitagawa Yasuaki Kabe Kenichi Horisawa Atsushi Suzuki Masaki Matsumoto Makoto Suematsu

&lt;p&gt;Fig.S8&lt;/p&gt;

10.1158/0008-5472.25515684.v1 preprint EN cc-by 2024-04-01
 List of Supplementary Information from PRMT1 Sustains <i>De Novo</i> Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer
OPENALEX - Publications 
Takehiro Yamamoto Tetsu Hayashida Yohei Masugi Kiyotaka Oshikawa Noriyo Hayakawa and 25 more Mai Itoh Chiyoko Nishime Masami Suzuki Aiko Nagayama Yuko Kawai Takako Hishiki Tomomi Matsuura Yoshiko Naito Akiko Kubo Arisa Yamamoto Yujiro Yoshioka Tomokazu Kurahori Misa Nagasaka Minako Takizawa Naoharu Takano Koji Kawakami Michiie Sakamoto Masatoshi Wakui Takushi Yamamoto Yuko Kitagawa Yasuaki Kabe Kenichi Horisawa Atsushi Suzuki Masaki Matsumoto Makoto Suematsu

&lt;p&gt;List of Supplementary Information&lt;/p&gt;

10.1158/0008-5472.25515750.v1 preprint EN cc-by 2024-04-01
 Supplementary Fig.S11 from PRMT1 Sustains <i>De Novo</i> Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer
OPENALEX - Publications 
Takehiro Yamamoto Tetsu Hayashida Yohei Masugi Kiyotaka Oshikawa Noriyo Hayakawa and 25 more Mai Itoh Chiyoko Nishime Masami Suzuki Aiko Nagayama Yuko Kawai Takako Hishiki Tomomi Matsuura Yoshiko Naito Akiko Kubo Arisa Yamamoto Yujiro Yoshioka Tomokazu Kurahori Misa Nagasaka Minako Takizawa Naoharu Takano Koji Kawakami Michiie Sakamoto Masatoshi Wakui Takushi Yamamoto Yuko Kitagawa Yasuaki Kabe Kenichi Horisawa Atsushi Suzuki Masaki Matsumoto Makoto Suematsu

&lt;p&gt;Fig.S11&lt;/p&gt;

10.1158/0008-5472.25515741 preprint EN cc-by 2024-04-01
 Supplementary Fig.S15 from PRMT1 Sustains <i>De Novo</i> Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer
OPENALEX - Publications 
Takehiro Yamamoto Tetsu Hayashida Yohei Masugi Kiyotaka Oshikawa Noriyo Hayakawa and 25 more Mai Itoh Chiyoko Nishime Masami Suzuki Aiko Nagayama Yuko Kawai Takako Hishiki Tomomi Matsuura Yoshiko Naito Akiko Kubo Arisa Yamamoto Yujiro Yoshioka Tomokazu Kurahori Misa Nagasaka Minako Takizawa Naoharu Takano Koji Kawakami Michiie Sakamoto Masatoshi Wakui Takushi Yamamoto Yuko Kitagawa Yasuaki Kabe Kenichi Horisawa Atsushi Suzuki Masaki Matsumoto Makoto Suematsu

&lt;p&gt;Fig.S15&lt;/p&gt;

10.1158/0008-5472.25515729.v1 preprint EN cc-by 2024-04-01
 List of Supplementary Information from PRMT1 Sustains <i>De Novo</i> Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer
OPENALEX - Publications 
Takehiro Yamamoto Tetsu Hayashida Yohei Masugi Kiyotaka Oshikawa Noriyo Hayakawa and 25 more Mai Itoh Chiyoko Nishime Masami Suzuki Aiko Nagayama Yuko Kawai Takako Hishiki Tomomi Matsuura Yoshiko Naito Akiko Kubo Arisa Yamamoto Yujiro Yoshioka Tomokazu Kurahori Misa Nagasaka Minako Takizawa Naoharu Takano Koji Kawakami Michiie Sakamoto Masatoshi Wakui Takushi Yamamoto Yuko Kitagawa Yasuaki Kabe Kenichi Horisawa Atsushi Suzuki Masaki Matsumoto Makoto Suematsu

&lt;p&gt;List of Supplementary Information&lt;/p&gt;

10.1158/0008-5472.25515750 preprint EN cc-by 2024-04-01
 Supplementary Fig.S20 from PRMT1 Sustains <i>De Novo</i> Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer
OPENALEX - Publications 
Takehiro Yamamoto Tetsu Hayashida Yohei Masugi Kiyotaka Oshikawa Noriyo Hayakawa and 25 more Mai Itoh Chiyoko Nishime Masami Suzuki Aiko Nagayama Yuko Kawai Takako Hishiki Tomomi Matsuura Yoshiko Naito Akiko Kubo Arisa Yamamoto Yujiro Yoshioka Tomokazu Kurahori Misa Nagasaka Minako Takizawa Naoharu Takano Koji Kawakami Michiie Sakamoto Masatoshi Wakui Takushi Yamamoto Yuko Kitagawa Yasuaki Kabe Kenichi Horisawa Atsushi Suzuki Masaki Matsumoto Makoto Suematsu

&lt;p&gt;Fig.S20&lt;/p&gt;

10.1158/0008-5472.25515705 preprint EN cc-by 2024-04-01
 Supplementary Fig.S17 from PRMT1 Sustains <i>De Novo</i> Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer
OPENALEX - Publications 
Takehiro Yamamoto Tetsu Hayashida Yohei Masugi Kiyotaka Oshikawa Noriyo Hayakawa and 25 more Mai Itoh Chiyoko Nishime Masami Suzuki Aiko Nagayama Yuko Kawai Takako Hishiki Tomomi Matsuura Yoshiko Naito Akiko Kubo Arisa Yamamoto Yujiro Yoshioka Tomokazu Kurahori Misa Nagasaka Minako Takizawa Naoharu Takano Koji Kawakami Michiie Sakamoto Masatoshi Wakui Takushi Yamamoto Yuko Kitagawa Yasuaki Kabe Kenichi Horisawa Atsushi Suzuki Masaki Matsumoto Makoto Suematsu

&lt;p&gt;Fig.S17&lt;/p&gt;

10.1158/0008-5472.25515720.v1 preprint EN cc-by 2024-04-01
 Supplementary Fig.S15 from PRMT1 Sustains <i>De Novo</i> Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer
OPENALEX - Publications 
Takehiro Yamamoto Tetsu Hayashida Yohei Masugi Kiyotaka Oshikawa Noriyo Hayakawa and 25 more Mai Itoh Chiyoko Nishime Masami Suzuki Aiko Nagayama Yuko Kawai Takako Hishiki Tomomi Matsuura Yoshiko Naito Akiko Kubo Arisa Yamamoto Yujiro Yoshioka Tomokazu Kurahori Misa Nagasaka Minako Takizawa Naoharu Takano Koji Kawakami Michiie Sakamoto Masatoshi Wakui Takushi Yamamoto Yuko Kitagawa Yasuaki Kabe Kenichi Horisawa Atsushi Suzuki Masaki Matsumoto Makoto Suematsu

&lt;p&gt;Fig.S15&lt;/p&gt;

10.1158/0008-5472.25515729 preprint EN cc-by 2024-04-01
 Supplementary Fig.S14 from PRMT1 Sustains <i>De Novo</i> Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer
OPENALEX - Publications 
Takehiro Yamamoto Tetsu Hayashida Yohei Masugi Kiyotaka Oshikawa Noriyo Hayakawa and 25 more Mai Itoh Chiyoko Nishime Masami Suzuki Aiko Nagayama Yuko Kawai Takako Hishiki Tomomi Matsuura Yoshiko Naito Akiko Kubo Arisa Yamamoto Yujiro Yoshioka Tomokazu Kurahori Misa Nagasaka Minako Takizawa Naoharu Takano Koji Kawakami Michiie Sakamoto Masatoshi Wakui Takushi Yamamoto Yuko Kitagawa Yasuaki Kabe Kenichi Horisawa Atsushi Suzuki Masaki Matsumoto Makoto Suematsu

&lt;p&gt;Fig.S14&lt;/p&gt;

10.1158/0008-5472.25515732.v1 preprint EN cc-by 2024-04-01
 Supplementary Fig.S19 from PRMT1 Sustains <i>De Novo</i> Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer
OPENALEX - Publications 
Takehiro Yamamoto Tetsu Hayashida Yohei Masugi Kiyotaka Oshikawa Noriyo Hayakawa and 25 more Mai Itoh Chiyoko Nishime Masami Suzuki Aiko Nagayama Yuko Kawai Takako Hishiki Tomomi Matsuura Yoshiko Naito Akiko Kubo Arisa Yamamoto Yujiro Yoshioka Tomokazu Kurahori Misa Nagasaka Minako Takizawa Naoharu Takano Koji Kawakami Michiie Sakamoto Masatoshi Wakui Takushi Yamamoto Yuko Kitagawa Yasuaki Kabe Kenichi Horisawa Atsushi Suzuki Masaki Matsumoto Makoto Suematsu

&lt;p&gt;Fig.S19&lt;/p&gt;

10.1158/0008-5472.25515714 preprint EN cc-by 2024-04-01
 Data from PRMT1 Sustains <i>De Novo</i> Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer
OPENALEX - Publications 
Takehiro Yamamoto Tetsu Hayashida Yohei Masugi Kiyotaka Oshikawa Noriyo Hayakawa and 25 more Mai Itoh Chiyoko Nishime Masami Suzuki Aiko Nagayama Yuko Kawai Takako Hishiki Tomomi Matsuura Yoshiko Naito Akiko Kubo Arisa Yamamoto Yujiro Yoshioka Tomokazu Kurahori Misa Nagasaka Minako Takizawa Naoharu Takano Koji Kawakami Michiie Sakamoto Masatoshi Wakui Takushi Yamamoto Yuko Kitagawa Yasuaki Kabe Kenichi Horisawa Atsushi Suzuki Masaki Matsumoto Makoto Suematsu

&lt;div&gt;Abstract&lt;p&gt;Triple-negative breast cancer (TNBC) chemoresistance hampers the ability to effectively treat patients. Identification of mechanisms driving can lead strategies improve treatment. Here, we revealed that protein arginine methyltransferase-1 (PRMT1) simultaneously methylates D-3-phosphoglycerate dehydrogenase (PHGDH), a critical enzyme in serine synthesis, and glycolytic enzymes PFKFB3 PKM2 TNBC cells. &lt;sup&gt;13&lt;/sup&gt;C metabolic flux analyses showed...

10.1158/0008-5472.c.7158201 preprint EN 2024-04-01
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