Akiyoshi Mizumoto

ORCID: 0009-0007-2110-8220
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About
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Research Areas
  • Intraperitoneal and Appendiceal Malignancies
  • Gastrointestinal motility and disorders
  • Ovarian cancer diagnosis and treatment
  • Appendicitis Diagnosis and Management
  • Neuropeptides and Animal Physiology
  • Neuroendocrine Tumor Research Advances
  • Hernia repair and management
  • Pain Mechanisms and Treatments
  • Diet and metabolism studies
  • Infant Health and Development
  • Gastric Cancer Management and Outcomes
  • Pancreatic and Hepatic Oncology Research
  • Occupational and environmental lung diseases
  • Gastrointestinal Tumor Research and Treatment
  • Clinical Nutrition and Gastroenterology
  • Intestinal and Peritoneal Adhesions
  • Helicobacter pylori-related gastroenterology studies
  • Pancreatitis Pathology and Treatment
  • Phenothiazines and Benzothiazines Synthesis and Activities
  • Neuroendocrine regulation and behavior
  • Layered Double Hydroxides Synthesis and Applications
  • Neuroscience of respiration and sleep
  • Pharmacological Effects of Natural Compounds
  • Uterine Myomas and Treatments
  • Pancreatic function and diabetes

Shiga Medical Center
2023

Tokatsu Hospital
2012-2022

Kishiwada Tokushukai Hospital
2016-2019

Kanazawa University
2014

Kitano Hospital
2004-2011

Gunma University
1993-2005

Mayo Clinic
1997-1999

Takeda (Japan)
1995

Tohoku University
1991-1994

Institute of Endocrinology
1993-1994

Abstract There is no standard treatment for peritoneal carcinomatosis (PC) from gastric cancer. New bidirectional chemotherapy (neoadjuvant intraperitoneal‐systemic protocol (NIPS)) was developed. The aim of the present study to assess safety and efficacy NIPS show selection cytoreductive surgery on PC Seventy‐nine patients with cancer were treated NIPS. A port system introduced into abdominal cavity. wash cytological examination through a done before after oral TS‐1 twice daily 21 days,...

10.1002/jso.21324 article EN Journal of Surgical Oncology 2009-08-20

Novel multidisciplinary treatment combined with neoadjuvant intraperitoneal-systemic chemotherapy protocol (NIPS) and peritonectomy was developed. Ninety-six patients were enrolled. Peritoneal wash cytology performed before after NIPS through a port system. Patients treated 60 mg/m 2 of oral S-1 for 21 days, followed by 1-week rest. On days 1, 8, 15, 30 Taxotere cisplatin 500 mL saline introduced the port. is done cycles surgery. Three weeks NIPS, 82 eligible to intend cytoreductive surgery...

10.1155/2012/148420 article EN cc-by International Journal of Surgical Oncology 2012-01-01

Background . Even though cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are associated with a high morbidity mortality rates, it has been reported that CRS HIPEC improved survival of selected patients peritoneal carcinomatosis. We aimed to report results from single institution in Japan. Methods Results Total 284 procedures were performed on pseudomyxoma peritonei, carcinomatosis (PC) colon cancer gastric between 2007 2011 our institution. The rate was 49%...

10.1155/2012/836425 article EN cc-by Gastroenterology Research and Practice 2012-01-01

The present study demonstrated prognostic factors for long-term survival in patients after a comprehensive treatment (CHT) peritoneal metastasis (PM) from gastric cancer (GC). Materials and Methods: Among 419 treated with neoadjuvant intraperitoneal/systemic chemotherapy (NIPS), 266 (63.5%) received complete resection (CC-0) of the macroscopic tumors. In total, 184 (43.9%) were postoperative systemic chemotherapy. Results: All who incomplete cytoreduction (CC-1) died GC within 6 years....

10.3390/cancers12010116 article EN Cancers 2020-01-01

We studied the effect of 5-hydroxytryptamine 3 (5-HT3) receptor antagonists on gastrointestinal (GI) motor activity in conscious dogs with force transducers implanted chronically. During digestive state, GR38032F, BRL 43694 and ICS 205-930 did not affect GI at all doses up to 1 mg/kg, whereas 24924 1.0 mg/kg i.v. significantly stimulated from stomach colon. When or was given 0.1 during phase I period, no direct observed activity, but treatment inhibited occurrence subsequent III completely...

10.1016/s0022-3565(25)23028-2 article EN Journal of Pharmacology and Experimental Therapeutics 1990-01-01

In the present article, we describe normal structure of peritoneum and review mechanisms peritoneal metastasis (PM) from gastric cancer (GC). The was studied by a double-enzyme staining method using alkaline-phosphatase 5'-nucreotidase, scanning electron microscopy, immunohistological methods. fundamental consists three layers, mesothelial cells basement membrane (layer 1), macula cribriformis (MC) 2), submesothelial connective tissue containing blood vessels initial lymphatic vessels,...

10.3390/jcm11020458 article EN Journal of Clinical Medicine 2022-01-17

The effect of motilin on insulin release has not been studied in the interdigestive state. Adult mongrel dogs were chronically implanted with force transducers stomach and duodenum to monitor contractile activity, plasma concentrations measured by a specific radioimmunoassay enzyme immunoassay, respectively. concentration was found fluctuate close association that phase III migrating contractions stomach. This spontaneous mimicked intravenous infusion at dose 0.3 μg ⋅ kg −1 h . Exogenous...

10.1152/ajpgi.1998.274.1.g87 article EN AJP Gastrointestinal and Liver Physiology 1998-01-01

During 2004 to 2011, 81, 420, and 166 patients with colorectal cancer (CRC), epithelial appendiceal neoplasm (APN), gastric (GC) PC were treated cytoreductive surgery (CRS) plus perioperative chemotherapy. CRS was performed by peritonectomy techniques using an aqua dissection. Results. Complete cytoreduction done in 62/81 (76.5%), 228/420 (54.3%), 101/166 (60.8%) of CRC, APN, GC. The main reasons incomplete resections involvement all peritoneal regions diffuse small bowel. incidence (64%,...

10.1155/2012/521487 article EN cc-by Gastroenterology Research and Practice 2012-01-01

The mechanism of associated fluctuations in plasma motilin and pancreatic polypeptide (PP) concentrations was studied fasted conscious dogs while gastric motility monitored. Plasma PP were measured by radioimmunoassay. In intact normal dogs, exogenous (0.03-0.3 g/kg) stimulated dose-related release PP, but did not stimulate release. Motilin-induced completely inhibited pretreatment with cholinergic blockers a 5-hydroxytryptamine3 (5-HT3) receptor antagonist, vagotomy. cyclic abolished after...

10.1152/ajpgi.1997.272.2.g224 article EN AJP Gastrointestinal and Liver Physiology 1997-02-01
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