A5063643956- Intraperitoneal and Appendiceal Malignancies
- Gastrointestinal motility and disorders
- Ovarian cancer diagnosis and treatment
- Appendicitis Diagnosis and Management
- Neuropeptides and Animal Physiology
- Neuroendocrine Tumor Research Advances
- Hernia repair and management
- Pain Mechanisms and Treatments
- Diet and metabolism studies
- Infant Health and Development
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Occupational and environmental lung diseases
- Gastrointestinal Tumor Research and Treatment
- Clinical Nutrition and Gastroenterology
- Intestinal and Peritoneal Adhesions
- Helicobacter pylori-related gastroenterology studies
- Pancreatitis Pathology and Treatment
- Phenothiazines and Benzothiazines Synthesis and Activities
- Neuroendocrine regulation and behavior
- Layered Double Hydroxides Synthesis and Applications
- Neuroscience of respiration and sleep
- Pharmacological Effects of Natural Compounds
- Uterine Myomas and Treatments
- Pancreatic function and diabetes
Shiga Medical Center
2023
Tokatsu Hospital
2012-2022
Kishiwada Tokushukai Hospital
2016-2019
Kanazawa University
2014
Kitano Hospital
2004-2011
Gunma University
1993-2005
Mayo Clinic
1997-1999
Takeda (Japan)
1995
Tohoku University
1991-1994
Institute of Endocrinology
1993-1994
Abstract There is no standard treatment for peritoneal carcinomatosis (PC) from gastric cancer. New bidirectional chemotherapy (neoadjuvant intraperitoneal‐systemic protocol (NIPS)) was developed. The aim of the present study to assess safety and efficacy NIPS show selection cytoreductive surgery on PC Seventy‐nine patients with cancer were treated NIPS. A port system introduced into abdominal cavity. wash cytological examination through a done before after oral TS‐1 twice daily 21 days,...
Novel multidisciplinary treatment combined with neoadjuvant intraperitoneal-systemic chemotherapy protocol (NIPS) and peritonectomy was developed. Ninety-six patients were enrolled. Peritoneal wash cytology performed before after NIPS through a port system. Patients treated 60 mg/m 2 of oral S-1 for 21 days, followed by 1-week rest. On days 1, 8, 15, 30 Taxotere cisplatin 500 mL saline introduced the port. is done cycles surgery. Three weeks NIPS, 82 eligible to intend cytoreductive surgery...
Background . Even though cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are associated with a high morbidity mortality rates, it has been reported that CRS HIPEC improved survival of selected patients peritoneal carcinomatosis. We aimed to report results from single institution in Japan. Methods Results Total 284 procedures were performed on pseudomyxoma peritonei, carcinomatosis (PC) colon cancer gastric between 2007 2011 our institution. The rate was 49%...
The present study demonstrated prognostic factors for long-term survival in patients after a comprehensive treatment (CHT) peritoneal metastasis (PM) from gastric cancer (GC). Materials and Methods: Among 419 treated with neoadjuvant intraperitoneal/systemic chemotherapy (NIPS), 266 (63.5%) received complete resection (CC-0) of the macroscopic tumors. In total, 184 (43.9%) were postoperative systemic chemotherapy. Results: All who incomplete cytoreduction (CC-1) died GC within 6 years....
We studied the effect of 5-hydroxytryptamine 3 (5-HT3) receptor antagonists on gastrointestinal (GI) motor activity in conscious dogs with force transducers implanted chronically. During digestive state, GR38032F, BRL 43694 and ICS 205-930 did not affect GI at all doses up to 1 mg/kg, whereas 24924 1.0 mg/kg i.v. significantly stimulated from stomach colon. When or was given 0.1 during phase I period, no direct observed activity, but treatment inhibited occurrence subsequent III completely...
In the present article, we describe normal structure of peritoneum and review mechanisms peritoneal metastasis (PM) from gastric cancer (GC). The was studied by a double-enzyme staining method using alkaline-phosphatase 5'-nucreotidase, scanning electron microscopy, immunohistological methods. fundamental consists three layers, mesothelial cells basement membrane (layer 1), macula cribriformis (MC) 2), submesothelial connective tissue containing blood vessels initial lymphatic vessels,...
The effect of motilin on insulin release has not been studied in the interdigestive state. Adult mongrel dogs were chronically implanted with force transducers stomach and duodenum to monitor contractile activity, plasma concentrations measured by a specific radioimmunoassay enzyme immunoassay, respectively. concentration was found fluctuate close association that phase III migrating contractions stomach. This spontaneous mimicked intravenous infusion at dose 0.3 μg ⋅ kg −1 h . Exogenous...
During 2004 to 2011, 81, 420, and 166 patients with colorectal cancer (CRC), epithelial appendiceal neoplasm (APN), gastric (GC) PC were treated cytoreductive surgery (CRS) plus perioperative chemotherapy. CRS was performed by peritonectomy techniques using an aqua dissection. Results. Complete cytoreduction done in 62/81 (76.5%), 228/420 (54.3%), 101/166 (60.8%) of CRC, APN, GC. The main reasons incomplete resections involvement all peritoneal regions diffuse small bowel. incidence (64%,...
The mechanism of associated fluctuations in plasma motilin and pancreatic polypeptide (PP) concentrations was studied fasted conscious dogs while gastric motility monitored. Plasma PP were measured by radioimmunoassay. In intact normal dogs, exogenous (0.03-0.3 g/kg) stimulated dose-related release PP, but did not stimulate release. Motilin-induced completely inhibited pretreatment with cholinergic blockers a 5-hydroxytryptamine3 (5-HT3) receptor antagonist, vagotomy. cyclic abolished after...