A5100759406- Supramolecular Self-Assembly in Materials
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Advanced biosensing and bioanalysis techniques
- Ionic liquids properties and applications
- Pickering emulsions and particle stabilization
- Chemical Synthesis and Analysis
- Lanthanide and Transition Metal Complexes
- Click Chemistry and Applications
- Surfactants and Colloidal Systems
- Nanoplatforms for cancer theranostics
- Electrocatalysts for Energy Conversion
- Catalysis and Oxidation Reactions
- Supramolecular Chemistry and Complexes
- RNA Interference and Gene Delivery
- Nanocluster Synthesis and Applications
- Iron oxide chemistry and applications
- Protein Degradation and Inhibitors
- Advanced Thermoelectric Materials and Devices
- Polymer composites and self-healing
- Mass Spectrometry Techniques and Applications
- Electronic and Structural Properties of Oxides
- Polydiacetylene-based materials and applications
- Advanced battery technologies research
- Boron and Carbon Nanomaterials Research
Nankai University
2022-2025
State Key Laboratory of Medicinal Chemical Biology
2022-2025
Fudan University
2017-2024
Tianjin University
2022-2024
Northeast Forestry University
2024
Beijing University of Chemical Technology
2023
Yunnan Normal University
2017-2019
Kunming University
2019
Shanghai University
2014
Proteolysis targeting chimera (PROTAC) technology is an innovative strategy for cancer therapy, which, however, suffers from poor delivery and limited capability protein of interest (POI) degradation. Here, we report a the in situ formulation antineoplastic Supra-PROTACs via intracellular sulfatase-responsive assembly peptides. Coassembling sulfated peptide with two ligands binding to ubiquitin VHL Bcl-xL leads formation pro-Supra-PROTAC, which ratio rationally optimized based on their...
Implementing dissipative assembly in living systems is meaningful for creation of materials or even artificial life. However, intracellular remains scarce and significantly impeded by the challenges lying precisely operating chemical reaction cycles under complex physiological conditions. Here, we develop organelle-mediated self-assembly peptides cells fueled GSH, via design a mitochondrion-targeting redox-responsive hexapeptide. While hexapeptide undergoes efficient self-assembly, addition...
It is challenging for ionic liquid gels to achieve the combination of rapid self-healing with high toughness. Here, (DI-PR) were prepared from readily available materials. A dynamic covalently bonded oxime-carbamate was polycaprolactone diol, isophorone diisocyanate and dimethylethyleneglyoxime, followed by addition "rigid-flexible" cross-linking agent rutin chemically cross-link polymer chains afford gels, DI-PR. The tensile strength, elongation at break toughness DI-PR as 16.5 MPa,...
Protein carboxyl methyltransferase (PCMT) restores aspartate isomers in proteins and plays a critical role cancer prognosis. However, vivo detection of PCMT remains challenging. Here, we report the isomerization-regulated situ assembly peptides into supramolecular probes within living cells for bladder cancer. The peptide consists alternating hydrophobic hydrophilic residues contains an isoAsp residue as kinked site to prevent facial amphiphilicity peptide. Exposure converts Asp peptide,...
Liquid-liquid phase separation (LLPS) of proteins and nucleic acids into membraneless organelles (MLOs) plays a critical role in sustaining fundamental physiological processes. However, creating artificial coacervate droplets living cells from exogenous molecules modulating the functions MLOs remain challenging. To address this concern, here we reported enzyme-induced situ peptides targeting MLO stress granule (SG) for enhanced cancer chemotherapy. The peptide YSO4F containing two sulfated...
In situ self-assembly of peptides in living cells regulated by biocompatible stimuli allows for precise creation well-defined nanostructures and thus offering a versatile strategy formulation biomedical agents at pathological lesions.
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The presence of disordered region or large interacting surface within proteins significantly challenges the development targeted drugs, commonly known as "undruggable" issue. Here, we report a heterogeneous peptide-protein assembling strategy to selectively phosphorylate proteins, thereby activating necroptotic signaling pathway and promoting cell necroptosis. Inspired by structures natural necrosomes formed receptor protein kinases (RIPK) 1 3, kinase-biomimetic peptides are rationally...
Bismuth porous nanosheets (Bi PNSs) were synthesized via a three-step process in the absence of any surfactants and templates. As catalyst for electrochemical CO2 electroreduction, Bi PNSs show high selectivity to formic acid with maximum Faraday efficiency 95.31% maintain more than 80% over wide voltage range 1100 mV. The excellent performance was found originate from abundant kink sites on pore walls, which have appropriate affinity intermediates reduce energy barriers electroreduction....
Abstract Targeted covalent inhibitors are promising for drug discovery and challenged by the strict structural features target proteins to sustain proximity‐induced conjugations. Herein, an assembly‐glued strategy is reported create surface‐displayed supramolecular that leverage display‐induced proximity between noncovalent ligands warheads. The ligand warhead obtained via attaching epidermal growth factor receptor (EGFR)‐binding segment or nitroreductase (NTR)‐activated moiety...
The mechanical properties of polyurethane ionogels prepared by UV light-curing are usually inferior to those conventional polyurethanes. Highly entangled polymer chain networks with chemical crosslinking can potentially address this problem. Here, we prepare (PU-HRs) using curing technology esterified rutin as a cross-linking agent. After optimization the preparation process response surface methodology, obtain PU-HRs tensile strength 34.96 MPa and toughness high 88.11 MJ m−3 (1.26-fold...
Alginate hydrogels containing YVO<sub>4</sub>–Eu<sup>3+</sup>have been prepared by using a facile method. These luminescent can be used as sensors to detect acetone with quick response and good reversibility.
Up to now, at least 806 carbon allotropes have been proposed theoretically. Three interesting (named Pbam -32, P 6/ mmm , and <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" overflow="scroll"> <mml:mrow> <mml:mi>I</mml:mi> <mml:mover accent="true"> <mml:mn>4</mml:mn> <mml:mo stretchy="false">¯</mml:mo> </mml:mover> <mml:mn>3</mml:mn> <mml:mi>d</mml:mi> </mml:mrow> </mml:math> ) were recently uncovered based on a random sampling strategy combined with space group graph theory. The...
Surface PEGylation is essential for preventing non-specific binding of biomolecules when silica nanoparticles are utilized in vivo applications. Methods installing poly(ethylene glycol) on a surface have been widely explored but varies from study to study. Because there lack satisfactory method evaluating the properties after PEGylation, prepared not fully characterized before use. In some cases, even non-PEGylated were produced, which unfortunately recognized by end-user. this work,...
The creation and propagation of longitudinal acoustic phonons (LAPs) in high quality hematite thin films (α-Fe2O3) epitaxially grown on different substrates (BaTiO3, SrTiO3, LaAlO3) are investigated using the femtosecond pump–probe technique. Transient reflection measurements (ΔR/R) indicate photo-excited electron dynamics, initial decay less than 1 ps slow ∼500 attributed to electron-LO phonon coupling electron–hole nonradiative recombination, respectively. LAPs α-Fe2O3 film can be created...
Abstract Bio‐inspired design of peptides represents one facile strategy for development supramolecular monomers self‐assembly into well‐defined nanostructures. Inspired by methylation arginine during post‐translational modification manipulating protein functions, herein, the controllable via rational incorporation methylated residues bola‐amphiphilic is reported. A series are designed and synthesized either containing natural or investigate influence on peptide assembly. This study finds...
Abstract The presence of disordered region or large interacting surface within proteins significantly challenges the development targeted drugs, commonly known as “undruggable” issue. Here, we report a heterogeneous peptide‐protein assembling strategy to selectively phosphorylate proteins, thereby activating necroptotic signaling pathway and promoting cell necroptosis. Inspired by structures natural necrosomes formed receptor protein kinases (RIPK) 1 3, kinase‐biomimetic peptides are...
Designing cheap, efficient, and stable electrocatalysts for hydrogen evolution reaction (HER) under ampere-level current density is essential the industrial water electrolysis technique. However, large H2 bubbles produced at high decrease activity stability of catalyst. Here, a self-supported electrode with porous yolk-shell CuNi@Cu electrocatalyst obtained via an alternant electrodeposition replacement during pulse process. The Cu shell can boost electrolyte diffusion serve as bubble fining...