A5069711021- Stress Responses and Cortisol
- Neurotransmitter Receptor Influence on Behavior
- Neuroendocrine regulation and behavior
- Resilience and Mental Health
- Anesthesia and Neurotoxicity Research
- Neuroscience and Neuropharmacology Research
- Birth, Development, and Health
- Pediatric Pain Management Techniques
- Forensic Toxicology and Drug Analysis
- Tryptophan and brain disorders
- Hypothalamic control of reproductive hormones
- Adipose Tissue and Metabolism
- Infant Development and Preterm Care
- Biochemical Analysis and Sensing Techniques
- Regulation of Appetite and Obesity
- Psychedelics and Drug Studies
University of Valparaíso
2018-2024
Steroid sex hormones produce physiological effects in reproductive tissues and also nonreproductive tissues, such as the brain, particularly cortical, limbic midbrain areas. Dopamine (DA) neurones involved processes prolactin secretion (tuberoinfundibular system), motor circuit regulation (nigrostriatal system) driving of motivated behaviour (mesocorticolimbic are specially regulated by hormones. Indeed, promote neurochemical behavioural induced drugs abuse tuning DA adult animals. However,...
Neonatal programming with sex hormones produces long-term functional changes in various tissues, including the brain. Previously, we demonstrated a higher content of dopamine and an increase potassium-induced release nucleus accumbens adult rats exposed to estradiol valerate. On other hand, also affect opioid system increasing expression μ receptor β-endorphins. Here, investigated if neonatal alters response morphine during adulthood predispose them neurochemical, rewarding behavioral...
Obesity is a pandemic caused by many factors, including chronic excess in hypercaloric and high-palatable food intake. In addition, the global prevalence of obesity has increased all age categories, such as children, adolescents, adults. However, at neurobiological level, how neural circuits regulate hedonic consumption intake reward circuit modified under diet are still being unraveled. We aimed to determine molecular functional changes dopaminergic glutamatergic modulation nucleus...
Early life exposure to sex hormones affects several brain areas involved in regulating locomotor and motivation behaviors. Our group has shown that neonatal testosterone propionate (TP) or estradiol valerate (EV) affected the dopamine (DA) system adulthood. Here, we studied long-lasting effects of on behavioral neurochemical responses amphetamine (AMPH) methylphenidate (MPD). results show AMPH-induced activity was higher female than male control rats. The conditioned place preference (CPP)...
Amphetamine derivatives have been used in a wide variety of pathologies because their pharmacological properties as psychostimulants, entactogens, anorectics, and antidepressants. However, adverse cardiovascular effects (sympathomimetics) substance abuse problems (psychotropic hallucinogenic effects) limited use. 4-Methylthioamphetamine (MTA) is an amphetamine derivative that has shown to inhibit monoamine uptake oxidase. the characterization (neurochemical, behavioral, safety) its...
Abstract Depression is a disabling and highly prevalent psychiatric illness. Multiple studies have linked glutamatergic dysfunction with the pathophysiology of depression, but exact alterations in system that contribute to depressive‐like behaviors are not fully understood. Recent evidence suggests decreased level neuronal glutamate transporter (EAAT3), known control levels limit activation receptors at synaptic sites, may manifestation depressive phenotype. Here, we tested possibility...
Neonatal programming with sex hormones produces long-term functional changes in various tissues, including the brain. For example, neonatal exposure to estrogens and androgens increases catecholamine content dopamine release brain circuits related reward locomotion. On other hand, can increase expression of mu-opioid receptor beta-endorphins. Therefore, could alter morphine response during adulthood rats predispose them addiction-like behaviors.