A5079051893- Prenatal Substance Exposure Effects
- Birth, Development, and Health
- Stress Responses and Cortisol
- Adipose Tissue and Metabolism
- Fatty Acid Research and Health
- Biochemical Analysis and Sensing Techniques
- Alcoholism and Thiamine Deficiency
- Folate and B Vitamins Research
- Regulation of Appetite and Obesity
- Neonatal and fetal brain pathology
- Memory and Neural Mechanisms
- Neurotransmitter Receptor Influence on Behavior
University of Valparaíso
2019-2023
Universidad Católica del Norte
2018-2019
Obesity is a pandemic caused by many factors, including chronic excess in hypercaloric and high-palatable food intake. In addition, the global prevalence of obesity has increased all age categories, such as children, adolescents, adults. However, at neurobiological level, how neural circuits regulate hedonic consumption intake reward circuit modified under diet are still being unraveled. We aimed to determine molecular functional changes dopaminergic glutamatergic modulation nucleus...
Prenatal ethanol exposure (PAE) induces behavioral maladptations in offspring, including a deficit memory formation which is part of the umbrella sign Fetal Alcohol spectrum disorder. Clinical and preclinical studies have shown that iron depletion exacerbates cognitive problems offspring exposed to utero PAE promotes dysregulation brain homeostasis. However, mechanisms underlying neuronal activity defects adolescent are unclear poorly understand. Here, we used rat model analyze mRNA protein...
Aims: Pre- and/or early postnatal ethanol exposure (prenatal alcohol [PAE]) impairs synaptic plasticity as well memory formation, but the mechanisms underlying these effects remain unclear. Both long-term potentiation (LTP) and spatial formation in hippocampus involve nicotinamide adenine dinucleotide phosphate oxidase type 2 (NOX2) enzyme. Previous studies have reported that N-methyl-d-aspartate receptor (NMDAR) activation increases NOX2-mediated superoxide generation, resulting inhibition...
Repeated exposure to alcohol increases retrieval of fear-conditioned memories, which facilitates, among other factors, the emergence post-traumatic stress disorder (PTSD). Individuals with PTSD are more likely develop and substance abuse related disorders. We assessed if prenatal early postnatal (PAE) increased susceptibility retain aversive memories this was associated subsequent heightened consumption. Pregnant Sprague-Dawley rats were exposed for 22 hr/day, throughout pregnancy until Day...