Ryanodine receptors (RyR) amplify activity-dependent calcium influx via calcium-induced release. Calcium signals trigger postsynaptic pathways in hippocampal neurons that underlie synaptic plasticity, learning, and memory. Recent evidence supports a role of the RyR2 RyR3 isoforms these processes. Along with signals, brain-derived neurotrophic factor (BDNF) is key signaling molecule for plasticity spatial Upon binding to specific TrkB receptors, BDNF initiates complex modify structure...

The COVID-19 pandemic has had a significant impact on populations at an economic, health, and interpersonal level, it is still unclear how affected health-risk behaviors, such as comfort food consumption over time. This study longitudinally examines the effect of perceived whether this mediated by emotional distress. A convenience sample 1048 students university staff (academic non-academic) from two universities completed monthly online surveys during across six waves (W; W1 to W6)....

Gastric diseases represent a significant global public health challenge, characterized by molecular dysregulation in redox homeostasis and heightened oxidative stress. Although prior preclinical studies have demonstrated the cytoprotective antioxidant effects of alginate oligosaccharides (AOSs) through Nrf2 pathway, whether such mechanisms apply to gastric remains unclear. In this study, we used GES-1 cell line exposed hydrogen peroxide (H2O2) as damage model investigate impact AOS on...

Urocortin (Ucn), a highly conserved metazoan gene, is related to stress and feeding, behaviors with significant gender differences. We investigated whether estrogens regulate the expression of Ucn gene using transient transfection in PC12 cells human (hUcn) promoter coupled luciferase either α or β estrogen receptors (ERα ERβ, respectively). The results demonstrate that estradiol (E 2 ) increases activity hUcn via ERα, decreases through ERβ. Deletions show increase mediated by E -ERα depends...

In vitro studies suggest that the intracellular C terminus of Neuroligin1 (NL1) could play a central role in maturation excitatory synapses. However, it is unknown how this activity affects synapses vivo , and whether may impact development complex behaviors. To determine NL1 influences state glutamatergic we compared synaptic behavioral phenotypes mice overexpressing full-length version (NL1FL) with missing part domain (NL1ΔC). We show overexpression yielded an increase proportion mature...

Ethanol exposure increases oxidative stress in developing organs, including the brain. Antioxidant treatment during maternal ethanol ingestion improves behavioral deficits rodent models of fetal alcohol spectrum disorder (FASD). However, impact general antioxidant their adult offspring and Specific Reactive Species (ROS)-dependent mechanism, are not fully understood. We hypothesized that pre early postnatal (PEE) modifies redox homeostasis, particular NOX2 function reward signaling...

The present study examines the trajectories of unhealthy food and alcohol consumption over time considers whether perceived impact COVID-19 psychological variables are predictors these trajectories. We ascertained different in women vs. men between living with without children. Data were collected through online surveys administered to 1038 participants from two universities (staff students) Chile, across five waves (July October 2020). Participants provided information about their past-week...

Prenatal ethanol exposure (PAE) induces behavioral maladptations in offspring, including a deficit memory formation which is part of the umbrella sign Fetal Alcohol spectrum disorder. Clinical and preclinical studies have shown that iron depletion exacerbates cognitive problems offspring exposed to utero PAE promotes dysregulation brain homeostasis. However, mechanisms underlying neuronal activity defects adolescent are unclear poorly understand. Here, we used rat model analyze mRNA protein...

Aims: Pre- and/or early postnatal ethanol exposure (prenatal alcohol [PAE]) impairs synaptic plasticity as well memory formation, but the mechanisms underlying these effects remain unclear. Both long-term potentiation (LTP) and spatial formation in hippocampus involve nicotinamide adenine dinucleotide phosphate oxidase type 2 (NOX2) enzyme. Previous studies have reported that N-methyl-d-aspartate receptor (NMDAR) activation increases NOX2-mediated superoxide generation, resulting inhibition...

Prenatal alcohol exposure (PAE) has serious physical consequences for children such as behavioral disabilities, growth disorders, neuromuscular problems, impaired motor coordination, and decreased muscle tone. However, it is not known whether loss of strength occurs, which interventions will effectively mitigate PAE impairments. We aimed to investigate alteration persists during adolescence exercise an effective intervention.

Patients with liver cirrhosis (LC) and minimal hepatic encephalopaty have a higher accident rate. LC impairs the normal sleep-awake cycle produces disturbances in behavior, cognition motor skills. Abnormal melatonin (MT) levels also been identified LC. Administration of MT may regulate circadian rhythms prevent oxidative damage. We studied effects on spatial memory acquisition (SMA) skills fibrosis model (LF)s.

Prenatal ethanol exposure is associated with neurodevelopmental defects and long-lasting cognitive deficits, which are grouped as fetal alcohol spectrum disorders (FASD). The molecular mechanisms underlying FASD incompletely characterized. Alternative splicing, including the insertion of microexons (exons less than 30 nucleotides in length), highly prevalent nervous system. However, whether can have acute or chronic deleterious effects this process poorly understood. In work, we used...

Los estudiantes universitarios suelen presentar una dieta poco saludable por estar expuestos, entre otros factores, a situaciones estresantes que se han visto exacerbadas la pandemia del COVID-19. Para enfrentar el estrés pueden utilizar diferentes estrategias, sin embargo, desconoce si los utilizado dichas estrategias y/o cambiado sus hábitos alimentarios como mecanismo para manejar durante pandemia. Este estudio evaluó generado de COVID-19 impactó en y las afrontamiento estrés. La...

Repeated exposure to alcohol increases retrieval of fear-conditioned memories, which facilitates, among other factors, the emergence post-traumatic stress disorder (PTSD). Individuals with PTSD are more likely develop and substance abuse related disorders. We assessed if prenatal early postnatal (PAE) increased susceptibility retain aversive memories this was associated subsequent heightened consumption. Pregnant Sprague-Dawley rats were exposed for 22 hr/day, throughout pregnancy until Day...

Hippocampus-dependent spatial and aversive memory processes entail Ca 2+ signals generated by ryanodine receptor (RyR) channels residing in the endoplasmic reticulum membrane. Rodents exposed to different tasks exhibit significant hippocampal RyR upregulation. Contextual fear conditioning generates robust memories through an associative learning process, but effects of contextual acquisition, consolidation, or extinction on protein levels remain unreported. Accordingly, here we investigated...

Durante la pandemia COVID-19 surgió una gran variedad de estresores que requirieron múltiples ajustes en vida diaria. El impacto ha diferido acuerdo al contexto nacional; por esto, resulta importante contar con instrumentos culturalmente pertinentes. Los objetivos del estudio fueron construir el Cuestionario Fuentes Estrés asociadas a (CFE) y evaluar sus propiedades psicométricas, examinar diferencias sociodemográficas las fuentes estrés percibidas. Se llevaron cabo cuatro fases: cualitativo...

Abstract
 Prenatal alcohol exposure (PAE) is highly prevalent worldwide, and can affect intake anxiety responses in the offspring. It still relatively unknown how PAE interacts with stress at adolescence, there a scarcity of treatments to reduce impact PAE. The present study assessed (ethanol) after tested modulation these by different housing conditions during early adolescence. Pregnant dams were exposed for 22 hours/day, from gestational day 0, throughout pregnancy, until postnatal 7...

Abstract The COVID-19 pandemic has had a significant impact on daily life, affecting both physical and mental health. Changes arising from the may longitudinally health-related behaviors (HRB). As different HRBs co-occur, in this study, we explore how six - alcohol (past-week binge-drinking), tobacco, marijuana, benzodiazepine use, unhealthy food consumption were grouped changed over time during pandemic. A sample of 1038 university students staff (18 to 73 years old) two universities...