A5073768405- Monoclonal and Polyclonal Antibodies Research
- Mesenchymal stem cell research
- Speech and Audio Processing
- Speech Recognition and Synthesis
- Mobile Agent-Based Network Management
- Microfluidic and Capillary Electrophoresis Applications
- Advanced Biosensing Techniques and Applications
- Analytical Chemistry and Chromatography
- Misinformation and Its Impacts
- Music and Audio Processing
- Birth, Development, and Health
- Protein Degradation and Inhibitors
- Protein purification and stability
- Multiple Myeloma Research and Treatments
- Chemical Synthesis and Analysis
- Innovative Microfluidic and Catalytic Techniques Innovation
- Catalytic Processes in Materials Science
- Pluripotent Stem Cells Research
- Robotic Path Planning Algorithms
- Microfluidic and Bio-sensing Technologies
- Asian Culture and Media Studies
- Fatty Acid Research and Health
- Tissue Engineering and Regenerative Medicine
- Multi-Agent Systems and Negotiation
- Peptidase Inhibition and Analysis
Fraunhofer Institute for Secure Information Technology
2023-2025
Korea Institute of Science and Technology
1994-2024
Gachon University
2022
Jeonju University
2022
College of Medical Sciences
2022
Hanyang University
2019-2021
Korea University
2021
JW Pharmaceutical (South Korea)
2016-2020
Anyang University
2020
Boryung Pharma (South Korea)
2011-2013
CWP232291 (CWP291) is a small-molecule inhibitor of Wnt signaling that causes degradation β-catenin via apoptosis induction through endoplasmic reticulum stress activation. This first-in-human, open-label, dose-escalation study to evaluate the safety, maximum tolerated dose (MTD), and preliminary efficacy CWP291 enrolled 69 patients with hematologic malignancies (acute myeloid leukemia [AML], n = 64; myelodysplastic syndrome, 5) in 15 cohorts 4 334 mg/m2 using modified 3+3 design 1...
This study characterizes the interactions between kabiramide C (KabC) and related macrolides actin establishes mechanisms that underlie their inhibition of filament dynamics cytotoxicity. The G-actin–KabC complex is formed through a two-step binding reaction extremely stable long-lived. Competition-binding studies show KabC binds to same site on G-actin as Gelsolin domain 1 CapG. also protomers within F-actin results in severing capping (+) end; these suggest free act biomimetics Gelsolin....
Simvastatin (SV), a HMG-CoA reductase inhibitor, is widely used for the treatment of hyperlipidaemia. The objectives present study were to develop population pharmacokinetic-pharmacodynamic (PK-PD) model simvastatin and evaluate its usefulness in predicting dose-response relationship patients with data obtained from drug-drug interaction assess effect aspirin on PK simvastatin. Twenty-seven healthy volunteers given 40 mg daily 14 days whom 100 q.d. was co-administered after day 8. Full...
The effect of adding Mo and/or Sb to a VTi catalyst on its activity and durability in the selective catalytic reduction (SCR) nitrogen oxide by NH3 was investigated. addition an appropriate amount Mo–Sb significantly improved specific surface area, enhanced number Brønsted acid sites, adjusted species composition. as Vn+ (n = 4, 3) fraction increased due formation functional groups surface. redox properties, active labile oxygen, oxygen vacancies were presence V2MoO8. This also played...
SOZ2– (Z = 3–4)-functionalized metal vanadates vary with the type of cations (Mn+) for Mn+-O2–-V5+ channels that fragment to impart Brönsted acidic bonds (BA–-H+; SOZ2–-H+) and labile/mobile oxygens (OL/OM) distinct populations affinities NOX/O2/H2O/SO2. SOZ2–-modified fragments bind NH3 activate Eley–Rideal (ER)-type selective catalytic NOX reduction (SCR), yet, hardly enable OL coordination are often hydrophilic, thereby limiting activities SCR or ammonium (bi)sulfate (AS/ABS)...
Audio deepfakes are becoming increasingly prevalent, posing a threat to companies who may fall victim CEO fraud, as well individuals be targeted by voice scams. As result, the need for audio deepfake detectors is growing. While academic research on exists, papers can difficult non-experts understand. Therefore, this article provides an introduction various state-of-the-art non-experts. Besides background information about and deep learning, evaluation metrics, commonly used datasets training...
Abstract An accurate and simple immunoassay using capillary electrophoresis (CE) with laser‐induced fluorescence (LIF) was performed for the detection of methamphetamine (MA) in urine. The CE‐LIF conducted an untreated fused‐silica column antiserum a tracer fluorescein isothiocyanate (FITC)‐labeled MA. This system compared polarization (FPIA) TDx analyzer photo‐check mode same FITC‐labeled antiserum. Various antibodies, not only those prepared by our own immunogens but also from commercial...
With the advancement of artificial intelligence, methods for generating audio deepfakes have improved, but technology behind it has become more complex. Despite this, non-expert users are able to generate due increased accessibility latest technologies. These technologies can be used support content creators, singers, and businesses such as advertisement or entertainment industries. However, they also misused create disinformation, CEO fraud, voice scams. Therefore, with increasing demand...
A gas chromatography/mass spectrometry method is described which uses negative ion chemical ionization and tandem mass for the determination of anabolic steroid metabolites. Four metabolites to be derivatized by Pentafluoropropionic anhydride (PFPA) were determined using (GC/MS) with (NCI) NCI/MS/MS. The repeatability reproducibility this procedure in range 5.3–9.7% 6.1–10.2%, respectively. This derivatization PFPA NCI NCI/MS/MS was useful determine four nandrolone, dromostanolone,...
A homogeneous fluorescence polarization immunoassay (FPIA) was developed to measure levels of progesterone in urine using a TDx analyzer photocheck mode (Abbott Labs). Two tracers ethylenediamine fluorescein thiocarbamyl (EDF) were employed; one synthesized from 11 alpha-hydroxyhemisuccinate (Prog-11OH-HS) and the other 3-(o-carboxymethyl)oxime (Prog-3CMO). Each derivative conjugated with bovine serum albumin used as an immunogen which produced monoclonal antibody clone 15A (MAb 15A,...
TPS8058 Background: CWP291, a novel peptidomimetic small molecule, has potent, selective inhibitory activity on Wnt gene reporter, decreasing expression of β-catenin target genes, cyclin D1 and survivin. With broad anti-cancer efficacy in vitro, it significantly outperforms lenalidomide as single agent combination MM bone marrow engraftment models. Methods: This Phase 1a/1b study (NCT #02426723) was designed to define well-tolerated dose CWP291 subjects with R/R MM. administered IV over ≥30...
An antibody was prepared, using a four carbon-bridged methamphetamine molecule as an immunogen in order to develop polarization fluoroimmunoassay for urine screening of and benzphetamine. Also, its binding characteristics were investigated locate epitope sites methamphetamine. The study showed that the highly capable eliciting response. However, detection limit much greater benzphetamine (0.05 ppm) than (0.2 weakly found with This difference sensitivity may reflect similarity used produce...