A5014680782- Adipokines, Inflammation, and Metabolic Diseases
- Tissue Engineering and Regenerative Medicine
- Tendon Structure and Treatment
- Reproductive Biology and Fertility
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Exercise and Physiological Responses
- 3D Printing in Biomedical Research
Czech Academy of Sciences, Institute of Experimental Medicine
2025
Czech Academy of Sciences
2025
Czech Academy of Sciences, Institute of Physiology
2023-2025
Charles University
2025
Czech Academy of Sciences, Institute of Microbiology
2024
Cytokine licensing with pro-inflammatory molecules, such as tumour necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ), has emerged a promising strategy to enhance the therapeutic potential of multipotent mesenchymal stromal cells (MSCs). While demonstrated benefits for immunomodulation, its effects on other key MSC functions, including differentiation paracrine activity, remain incompletely explored. In this study, we evaluated transcriptomic, metabolomic, functional changes induced...
Organoids represent indispensable opportunities for biomedicine, including drug discovery, cancer biology, regenerative and personalised medicine or tissue organ transplantation. However, the lack of optimized preservation strategies limits wide use organoids in research clinical fields. In this review, we present a short outline recent developments organoid current cryopreservation systems. While both vitrification slow controlled freezing have been utilized structures their precursor...
HelD protein, also named HelR (encoded by MSMEG_2174 in Mycobacterium smegmatis), interacts with mycobacterial RNA polymerase (RNAP) and affects rifampicin resistance abscessus. Here, we provide data on helD presence the genomes of other clinically relevant nontuberculous mycobacteria. We show that is primarily found rapidly growing mycobacteria, such as M. smegmatis, where detected at a subset promoters can associate CarD RbpA. Transcriptome analysis deletion strain using RNA-seq revealed...