A catalytic C(sp²)–F bond carboxylation with CO₂ is reported; the reaction enabled by dual photoredox/palladium catalysis and involves a crucial fluoroalkenyl radical intermediate.

Abstract Nitrogen availability and illumination intensity are two key factors which affect rice growth. However, their influences on total nitrogen accumulation, photosynthetic rate, root morphologies, yields not fully understood. We conducted field experiments to (1) evaluate the effects of shading under different N treatments parameters, nutrient grain rice; (2) elucidate relationship between accumulation morphologies conditions treatments. Three rates, three treatments, cultivars were...

A novel strategy for the expedient construction of CF3 -embeded tertiary/quarternary carbon centers was developed by taking advantage photoredox catalysis. Thanks to a key step single-electron oxidation, electron-rich gem-difluoroalkenes, which otherwise are essentially reluctant towards F-nucleoplilic addition, now readily participate in this fluoroallylation reaction. Furthermore, provides an elegant example generation, as well functionalization, α-CF3 -substituted benzylic radical...

Herein, we report the first example of group transfer radical addition O-vinylhydroxylamine derivatives onto unactivated alkenes. By utilizing as both N- and C-donors, this reaction enables intermolecular carboamination alkenes in an atom economical fashion. As process is initiated through N-radical followed by C-transfer, linear products are afforded. This differs from canonical carbofunctionalization olefins, which typically favors branched product owing to initiation C-radical addition.

Deep placement of nitrogen fertilizer is a key strategy for improving use efficiency. A two-year field experiment was conducted during the early rice growing seasons (March–July) 2016 and 2017. The experimental treatments comprised two cultivars: Wufengyou 615 (WFY 615) Yuxiangyouzhan (YXYZ), three N treatments: mechanical deep all fertilizers as basal dose at 10 cm soil depth (one-time deep-placement fertilization, namely OTDP fertilization); manual surface broadcast (the common farmer...

We have identified a mouse recessive mutation that leads to attenuated and hyperpermeable retinal vessels, recapitulating some pathological features of familial exudative vitreoretinopathy (FEVR) in human patients. DNA sequencing reveals single nucleotide insertion the gene encoding low-density lipoprotein receptor-related protein 5 (LRP5), causing frame shift resulting replacement C-terminal 39 amino acid residues by 20 new acids. This change eliminates last three PPP(S/T)P repeats LRP5...

A strategically novel protocol for ring-opening functionalization of aryl gem-difluorocyclopropanes (F2CPs), which allows an expedient construction CF3-containing architectures via visible-light-promoted F-nucleophilic attack manifold, was disclosed. Single electron oxidation F2CPs ascribed as the critical step success this transformation by prompting attack, well ensuing C–C bond scission. The observed intriguing regioselectivity fluoroincorporation in reaction rationalized invoking...

A new type of donor–acceptor cyclopropane with gem -difluorine as an unconventional donor group undergoes (3 + 2)-cycloadditions various aldehydes/ketones, affording densely functionalized -difluorotetrahydrofurans.

A novel and efficient methodology that allows for the construction of Ar-P bonds via Pd-catalyzed oxidative cross-coupling reaction various arylsilanes with H-phosphonates leading to valuable arylphosphonates has been developed.

Eight novel compounds were synthesized and their insecticidal activities tested.The of 3d, 3e 3g showed activity against Aphis rumicis Linnaeus .All the title characterized on basis IR, 1 H NMR HRMS.

The palladium-catalyzed oxidative arylation of indolines with arylsilanes at the C-7 position via C–H bond activation has been reported. This transformation applied to a wide range substrates. It represents facile access arylated indolines, which can be conveniently transformed into indoles.

Abstract Although highly appealing for rapid access of molecular complexity, multi‐functionalization alkenes that allows incorporation more than two functional groups remains a prominent challenge. Herein, we report novel strategy merges dipolar cycloaddition with photoredox promoted radical ring‐opening remote C(sp 3 )−H functionalization, thus enabling smooth 1,2,5‐trifunctionalization unactivated alkenes. A regioselective [3+2] anchors reaction trigger onto alkene substrates. The...

Astragaloside Ⅳ (AS‑Ⅳ) in improving liver cirrhosis injury rats and its effect on the phosphoinositide 3‑kinase (PI3K)/protein kinase B (Akt)/mechanistic target of rapamycin (mTOR) signaling pathway were observed. Rat model was induced by injection carbon tetrachloride (CCl4). A total 36 Sprague‑Dawley (SD) randomly divided into three groups: normal control group (n=10), (n=13), AS‑Ⅳ (n=13). The injected with olive oil given carboxymethyl cellulose (CMC)‑Na (10 ml/kg/day), CMC‑Na underwent...

Metathesis reactions of YbI2 with Li2L (L = Me3SiN(Ph)CN(CH2)3NC(Ph)NSiMe3) in THF at a molar ratio 1:1 and 1:2 both afforded the Yb(II) iodide complex [{YbI(DME)2}2(μ2-L)] (1), which was structurally characterized to be dinuclear bridged L ligand. Treatment EuI2 did not afford analogous [{EuI(DME)2}2(μ2-L)], or another isolable Eu(II) complex, but hexanuclear heterobimetallic cluster [{Li(DME)3}+]2[{(EuI)2(μ2-I)2(μ3-L)2(Li)4}(μ6-O)]2– (2) isolated as byproduct trace yield. The rational...

As a kind of important organometallic reagents, organosilanes have been widely applied for C-C bond formation in organic synthesis.In this paper, recent development trans-metal-catalyzed C-H functionalizations involving is reviewed, which Pd-catalyzed Hiyama coupling reactions described as highlighted.

Abstract A novel strategy for the expedient construction of CF 3 ‐embeded tertiary/quarternary carbon centers was developed by taking advantage photoredox catalysis. Thanks to a key step single‐electron oxidation, electron‐rich gem ‐difluoroalkenes, which otherwise are essentially reluctant towards F‐nucleoplilic addition, now readily participate in this fluoroallylation reaction. Furthermore, provides an elegant example generation, as well functionalization, α‐CF ‐substituted benzylic...

Abstract Selective C−F bond functionalization of CF 3 group represents an appealing strategy for the incorporation pharmaceutically privileged difluoromethylene moiety. Despite recent significant advancement attained in Ar‐CF molecules, prescriptions amenable alkenyl‐CF congeners remain sufficiently inadequate. Herein, we report a strategically novel protocol elaboration trifluoromethylalkene derivatives. By using readily available allyl metallics as nucleophilic coupling partner, present...

An efficient and versatile copper- or iron-catalyzed direct stereoselective β-C(sp 2 )–H methylation of enamides by using dicumyl peroxide (DCP) as the methylating reagent has been developed.

The practice of conservation tillage or straw returning to the farmland influences grain yield and quality rice (Oryza sativa). key volatile compound responsible for fragrance in fragrant is 2-acetyl-1-pyrroline (2-AP), which significantly affected by field management measures. purpose this study was investigate impact on biosynthesis 2-AP rice. This conducted over two years 2016 2017 utilized cultivars (Meixiangzhan 2 Xiangyaxiangzhan) as materials. It consisted different managements...

Comprehensive Summary We herein describe a Cp*Rh III ‐catalyzed C(sp 3 )–H mono‐arylation of 8‐methylquinolines with benign arylsilanes. The use 1‐adamantane carboxylic acid can benefit the efficiency in this transformation, and AgF was both activator reoxidant. Control experiments indicated inability C—H cleavage determining rate reaction.

Abstract The air mediated radical alkylation of cyclic aldimines via autoxidation alkylboronic acids has been realized under mild reaction conditions. By simply heating with acid using as sole oxidant, this protocol provides a catalyst‐free access to variety alkylated 21–91% yields. Preliminary mechanistic studies suggest that pathway might be involved in the reaction.