A5057162947- Cardiomyopathy and Myosin Studies
- Lysosomal Storage Disorders Research
- Potassium and Related Disorders
- Trypanosoma species research and implications
- Cardiovascular Function and Risk Factors
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Cardiac pacing and defibrillation studies
- Coronary Artery Anomalies
- Williams Syndrome Research
- Cellular transport and secretion
- Studies on Chitinases and Chitosanases
- Chemotherapy-induced cardiotoxicity and mitigation
- Eosinophilic Disorders and Syndromes
- PI3K/AKT/mTOR signaling in cancer
- Forensic Toxicology and Drug Analysis
- Genomics and Rare Diseases
- Glycogen Storage Diseases and Myoclonus
- Cannabis and Cannabinoid Research
- Poisoning and overdose treatments
- Sports injuries and prevention
- Sex and Gender in Healthcare
- Cardiovascular Syncope and Autonomic Disorders
- Protein Kinase Regulation and GTPase Signaling
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
University of Alberta
2019-2025
Alberta Hospital Edmonton
2020
Stroke-heart syndrome describes the neurocardiogenic mechanisms that lead to development of poststroke cardiovascular complications. We describe a 25-year-old man with Carvajal who developed advanced biventricular heart failure 2 months after large territory ischemic stroke. His condition was managed inotropic support initially and required assist devices as bridge possible transplantation. This case highlights increased risk complications stroke through dysregulation brain-heart axis....
Fabry Disease (FD) is a systemic disorder that can result in cardiovascular, renal, and neurovascular disease leading to reduced life expectancy. FD should be considered the differential of all patients with unexplained left ventricular hypertrophy (LVH). We therefore performed prospective screening study Edmonton Hong Kong using Dried Blood Spot (DBS) testing on undiagnosed LVH. Participants found have LVH echocardiography were invited participate subsequently subjected DBS testing. was...
Iron overload cardiomyopathy (IOC) is a major co-morbidity of genetic hemochromatosis and secondary iron with limited therapeutic options. We aim to investigate mechanisms rescue action amlodipine in the murine model overload, characterize changes human cardiac tissue due IOC, compare them animal IOC.As an model, we used male hemojuvelin knockout (HJVKO) mice, which lacked (a co-receptor protein for hepcidin expression). The mice were fed high-iron diet from 4 weeks 1 year age. As rescue,...
Introduction: Despite new advances in heart failure (HF) management, underutilization of guideline-directed medical therapy (GDMT) persists. In addition, contemporary data on GDMT utilization and whether sex differences exist is unclear. We aim to characterize use across HF subtypes, investigate sex-based disparities utilization, explore these impacts patient quality life markers clinical outcomes. Methods: Patients with were enrolled the function clinic (HFC) Edmonton, Alberta, from Feb...
Abstract Aims Patients with cardiomyopathies are a heterogeneous group of patients who experience high morbidity and mortality. Early cardiac assessment intervention access to genetic counselling in multidisciplinary Cardiomyopathy Clinic may improve outcomes prevent progression advanced heart failure. Methods results Our prospective cohort study was conducted at 421 enrolled (42.5% female, median age 58 years), including 224 dilated cardiomyopathy (DCM, 42.9% 57 72 hypertrophic (HCM, 43.1%...
Purpose: Asthma is the most common chronic disease among children. Exercise-induced bronchoconstriction which in asthmatic patients also occurs individuals with no prior asthma diagnosis. Despite this and fact that soccer a high ventilation sport, there are validated management protocols place for coaches. This study aims to address 1) coaches’ current knowledge on asthma, 2) whether need asthma-related training, 3) any barriers administration of such training. Patients methods: A total...
Introduction: Sodium/glucose cotransporter 2 inhibitors (SGLT2i) have an established benefit in people with diabetes mellitus (DM) and chronic heart failure (HF). We aimed to evaluate the uptake impact of these agents two cohorts: a community-based cohort all adults DM HF Alberta who had echocardiogram being cared for specialized clinic (HFC). Methods: identified using validated ICD code-based case definitions (physician claims, outpatient, hospitalization databases) study (available from...
Introduction: Patients with genetic cardiomyopathies are a heterogeneous group of patients who experience significant morbidity and mortality. Early cardiac assessment intervention coupled access to counselling testing may improve clinical outcomes prevent progression end-stage heart failure. Methods: Our prospective cohort study was conducted at our multidisciplinary Cardiomyopathy Clinic suspected cardiomyopathy (CM) or family history CM ( n =405) were recruited. analysis completed =228)...