A5058079711- Sodium Intake and Health
- Atherosclerosis and Cardiovascular Diseases
- Cancer, Lipids, and Metabolism
- Lipid metabolism and biosynthesis
- Genetic Mapping and Diversity in Plants and Animals
- DNA Repair Mechanisms
- Nuclear Structure and Function
- Adipokines, Inflammation, and Metabolic Diseases
- Antioxidant Activity and Oxidative Stress
- Hormonal Regulation and Hypertension
- RNA modifications and cancer
- Genomics and Chromatin Dynamics
- Microbial Metabolic Engineering and Bioproduction
- Fungal and yeast genetics research
Vanderbilt University Medical Center
2023-2024
Xavier University
2021-2022
BACKGROUND: Salt sensitivity of blood pressure (SSBP), characterized by acute changes in with dietary sodium intake, is an independent risk factor for cardiovascular disease and mortality people without hypertension. We previously found that elevated concentration activates antigen-presenting cells (APCs), resulting high pressure, but the mechanisms are unknown. Here, we hypothesized APC-specific JAK2 (Janus kinase 2) through STAT3 (signal transducer activator transcription 3) SMAD3 (small...
Studying acute changes in vascular endothelial cells humans is challenging. We studied ten African American women and used the J-wire technique to isolate vein before after a four-hour lipid heparin infusion. Dynamic lipid-induced oxidative stress inflammatory markers were measured with fluorescence-activated cell sorting. surface CD31 CD144 identify human cells. Peripheral blood mononuclear isolated from as negative control. The participants received galantamine (16 mg/day) for 3 months....
Cell metrics such as area, length, and width provide informative data about cell cycle dynamics. Factors that affect these dimensions include environmental conditions genotypic differences. Fission yeast ( Schizosaccharomyces pombe ) is a rod-shaped ascomycete fungus in which progression linked to changes length. Microscopy work obtain places considerable burdens on time effort. We now report Photo Phenosizer (PP), machine learning-based methodology measures fission yeast. It does this an...
DGAT2 is a transmembrane protein encoded by the gene that functions in lipid metabolism, triacylglycerol synthesis, and droplet regulation. Cancer cells exhibit altered metabolism mutations may contribute to this state. Using data from Catalogue of Somatic Mutations (COSMIC), we analyzed all cancer genetic alterations, including mutations, copy number variations expression. We find several fall within catalytic site enzyme. Variant Effect Scoring Tool (VEST), identify multiple with high...
Abstract Salt-sensitivity of blood pressure (SSBP), characterized by acute changes in with dietary sodium intake, is an independent risk factor for cardiovascular disease and mortality people without hypertension. We previously found that elevated concentration activates antigen presenting cells (APCs), resulting high pressure, but the mechanisms are not known. Here, we hypothesized APC-specific JAK2 expression contributes to SSBP. performed bulk or single-cell transcriptomic analyses...
Abstract Lipids are essential for cell growth and maintenance, intracellular signaling, cellular energetics. When exposed to environmental insults, cells activate lipid metabolism programs that facilitate the response, recovery, exit from stressful conditions. Failure regulate storage utilization is associated with accelerated aging, which compounds genomic instability. In this study, we test physiological consequences of disruptions three regulator genes frequently found be mutated in human...
Abstract Diacylglycerol O-acyltransferase 2 is a transmembrane protein encoded by the DGAT2 gene that functions in lipid metabolism, triacylglycerol synthesis, and droplet regulation. Since cancer cells exhibit altered it has been proposed mutations may contribute to this state. Using data from Catalogue of Somatic Mutations Cancer (COSMIC), we analyzed all reported human cancers. Bioinformatics analyses were performed highlight connections between age, pathogenicity, tissue type. are...