Kritika Shankar
A5038308864- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Epilepsy research and treatment
- Cancer Genomics and Diagnostics
- Genetics and Neurodevelopmental Disorders
- Colorectal Cancer Screening and Detection
- Genomics and Rare Diseases
- Genomics and Phylogenetic Studies
- Gene expression and cancer classification
- Liver Disease Diagnosis and Treatment
- Food Security and Health in Diverse Populations
- Banana Cultivation and Research
- RNA and protein synthesis mechanisms
Cleveland Clinic
2025
Cleveland Clinic Lerner College of Medicine
2024-2025
Cerner (United States)
2025
Transgenomic (United States)
2017-2018
Jackson Laboratory
2017
Abstract Background Addressing critical gaps in precision medicine initiatives colorectal cancer (CRC) requires building larger collaborative studies. Methods The Latino Colorectal Cancer Consortium (LC3) is a resource that harmonizes data collected observational studies with from individuals who identify as Hispanic/Latino diagnosis of primary adenocarcinoma. Data includes demographics, medical history, family and lifestyle risk factors patient-completed surveys. Vital status, cause death,...
Abstract Ancestrally diverse and admixed populations, including the Hispanic/Latino/a/x/e community, are underrepresented in cancer genetic/genomic studies. Leveraging Latino Colorectal Cancer Consortium (LC3) other existing datasets, we analyzed whole exome sequencing data on tumor/normal pairs from 718 individuals with colorectal to map somatic mutational features by ethnicity genetic similarity. Global proportions of African, Asian, European, Native American ancestries were estimated...
<p>MSI score by clinically determined MSI status in 718 study participants</p>
<p>Mutation spectrum of APC, TP53 and KRAS in 718 colorectal cancer patients</p>
<p>Mutational pattern of top mutated genes in 718 colorectal cancer patients</p>
<p>Estimated genetic ancestry for 718 colorectal cancer patients stratified by study cohort</p>
<p>Correlation between genetic ancestry and gene mutation status of KNCN TMEM184B in 718 colorectal cancer patients</p>
<p>Tumor mutation burden distribution and MSI score in 718 colorectal cancer patients</p>
<div>Abstract<p>Admixed populations, including the Hispanic/Latino/a community, are underrepresented in cancer genetic/genomic studies. Leveraging Latino Colorectal Cancer Consortium (LC3) and other existing datasets, we analyzed whole-exome sequencing data on tumor/normal pairs from 718 individuals with colorectal to map somatic mutational features by ethnicity genetic similarity. Global proportions of African, Asian, European, Native American ancestries were estimated using...
<p>Supplementary Materials includes participants and biospecimens, sample selection, sequence trimming, alignment, alignment refinement, germline variant calling, somatic mutation detection, population-level allele frequency filter, processing for genetic ancestry modeling, population structure estimation.</p>
<p>Mutational landscape in 128 Latino colorectal cancer patients</p>
<p>Mutation frequency for KNCN and TMEM184B in 597 colorectal cancer patients by ethnicity</p>