A5116034739- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Prostate Cancer Treatment and Research
Inserm
2025
Aix-Marseille Université
2025
Centre National de la Recherche Scientifique
2025
Centre d’Immunologie de Marseille-Luminy
2025
Abstract Prostate cancer is a heterogeneous disease with slow progression and highly variable clinical outcome. The tumor suppressor genes PTEN TP53 are frequently mutated in prostate predictive of early metastatic dissemination unfavorable patient outcomes. solid tumors to metastasis often associated increased cell plasticity, but the complex events underlying -loss-induced aggressiveness remain incompletely understood. Using genetically engineered mice, we show that Trp53 deficiency Pten...