J LI

ORCID: 0009-0007-4262-1429
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About
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Research Areas
  • Chemical Synthesis and Analysis
  • Cell death mechanisms and regulation
  • Chemical Synthesis and Reactions
  • Advanced Sensor and Energy Harvesting Materials
  • Tribology and Wear Analysis
  • Transition Metal Oxide Nanomaterials
  • Ginseng Biological Effects and Applications
  • Cancer-related molecular mechanisms research
  • Iron Metabolism and Disorders
  • RNA modifications and cancer
  • Cancer Research and Treatments
  • Genomics, phytochemicals, and oxidative stress
  • Conducting polymers and applications
  • Inorganic and Organometallic Chemistry
  • Epigenetics and DNA Methylation
  • Cancer Mechanisms and Therapy
  • Ga2O3 and related materials
  • Ubiquitin and proteasome pathways
  • Nanomaterials for catalytic reactions
  • Peptidase Inhibition and Analysis
  • Polymer composites and self-healing
  • MicroRNA in disease regulation
  • Silicone and Siloxane Chemistry
  • Cancer Cells and Metastasis
  • Synthesis and Reactivity of Sulfur-Containing Compounds

Chang'an University
2024

Jilin University
2007-2023

Jilin Medical University
2016

Union Hospital
2008

Shenyang University of Technology
2008

The High Friction Surface Treatment (HFST) paving technique is widely employed in engineering practices globally, serving to enhance the long-term anti-skid performance of pavements. However, there still exist significant gaps research regarding modified and optimized composition corresponding content polymer binding materials used HFST, as well pavements laid with blended aggregates during service. To address these issues, this first ratio traditional epoxy resin materials. Subsequently, a...

10.1016/j.cscm.2024.e03431 article EN cc-by-nc Case Studies in Construction Materials 2024-06-17

Synthetic lethality has recently emerged as a new approach for the treatment of mutated genes that were previously considered undruggable. Targeting methionine adenosyltransferase 2A (MAT2A) in cancers with deletion methylthioadenosine phosphorylase (MTAP) gene leads to synthetic and thus attracted significant interest field precise anticancer drug development. Herein, we report discovery series novel MAT2A inhibitors featuring pyrazolo[3,4-

10.1021/acs.jmedchem.4c00552 article EN Journal of Medicinal Chemistry 2024-05-31

Prostate cancer is one of the most frequently diagnosed cancers among men. Dietary intake nutrients considered crucial for preventing initiation events leading to development carcinoma. Many dietary compounds have been contribute prevention including zinc, which has a pivotal role in modulating apoptosis. However, mechanism zinc-mediated prostate chemoprevention remains enigmatic. In this study, we investigated therapeutic effect zinc first time. Exposure induced apoptosis and resulted...

10.1038/cddis.2013.333 article EN cc-by Cell Death and Disease 2013-09-19

Lung cancer seriously threatens human health. To explore the molecular mechanism of 20(S)-Protopanaxadiol (PPD) on non-small cell lung cells, we investigated transcriptional profile PPD-treated NCI-H1299 cells. Cell proliferation, cycle, and apoptosis were detected using counting kit-8 flow cytometry, respectively. Differentially expressed genes (DEGs) between untreated cells determined RNA sequencing bioinformatic analysis. Protein phosphorylation was Western blotting. Data mRNA expression...

10.3390/molecules28155746 article EN cc-by Molecules 2023-07-29

10.1016/s1005-9040(08)60044-6 article EN Chemical Research in Chinese Universities 2008-03-01
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