A5101506048- Adipose Tissue and Metabolism
- Bone Metabolism and Diseases
- Diet and metabolism studies
- Mitochondrial Function and Pathology
- Gut microbiota and health
- Transgenic Plants and Applications
- Cell Adhesion Molecules Research
- Genetically Modified Organisms Research
- Protein Tyrosine Phosphatases
- Galectins and Cancer Biology
- Metabolism and Genetic Disorders
- Insect Resistance and Genetics
- Cancer, Stress, Anesthesia, and Immune Response
- Bone health and osteoporosis research
- Pancreatic and Hepatic Oncology Research
- Reproductive System and Pregnancy
- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
- Metabolism, Diabetes, and Cancer
- Bone health and treatments
Corteva (United States)
2023
Medical University of South Carolina
2017-2019
Baton Rouge Clinic
2018
California Polytechnic State University
2009
St. Louis VA Medical Center
2007
Objective— Aortic calcification is prevalent in type II diabetes (T2DM), enhancing morbidity and tracking metabolic syndrome parameters. Ldlr −/− mice fed high-fat “Westernized” diets (HFD) accumulate aortic calcium primarily the tunica media, mediated via osteogenic morphogens transcriptional programs that induce alkaline phosphatase (ALP). Because elevated TNF-α characteristic of obesity with T2DM, we examined contributions this inflammatory cytokine. Methods Results— HFD promoted obesity,...
Abstract Despite knowledge the gut microbiota regulates bone mass, mechanisms governing normal microbiota’s osteoimmunomodulatory effects on skeletal remodeling and homeostasis are unclear in healthy adult skeleton. Young specific-pathogen-free germ-free mice were used to delineate commensal immunoregulatory osteoblastogenesis, osteoclastogenesis, marrow T-cell hematopoiesis, extra-skeletal endocrine organ function. We report has anti-anabolic suppressing osteoblastogenesis pro-catabolic...
Commensal gut microbiota–host immune responses are experimentally delineated via gnotobiotic animal models or alternatively by antibiotic perturbation of microbiota. Osteoimmunology investigations in germ-free mice, revealing that microbiota immunomodulatory actions critically regulate physiologic skeletal development, highlight may dysregulate normal osteoimmunological processes. We investigated the impact disruption on osteoimmune response effects postpubertal development. Sex-matched...
Previous work demonstrated the utility of using human-derived intestinal epithelial cell (IEC) lines cultured as polarized monolayers on Transwell® filters to differentiate between hazardous and non-hazardous proteins. The current study seeks further resolve appropriate concentrations for evaluating proteins unknown hazard potential IEC experimental platform leverages these parameters toxicity insecticidal characteristic those expressed in genetically modified (GM) agricultural biotechnology...
Metformin (Met) is the most commonly prescribed antidiabetic agent worldwide. Although it has been marketed in U.S. for over two decades, exact molecular mechanisms of Met remain controversial. In addition to suppression hepatic gluconeogenesis, increasing evidence suggests induces extrahepatic tissue-specific effects, such as skeletal muscle (SKM), where mitochondrion believed be primary cellular target. We investigated effects on mitochondrial pathways human SKM cells isolated by...
The role of mitochondria in insulin resistance and type 2 diabetes (T2D) is the subject much debate. Recent evidence has suggested presence altered skeletal muscle mitochondrial dynamics, both increased fission reduced fusion, etiology T2D, however, it unclear what role, if any, changes dynamics play induction resistance. We have proposed that may represent an early mechanistic link between onset To test this hypothesis we recruited healthy humans to receive, a randomized crossover design,...
Introduction: The integrity, morphology, structure and functionality of skeletal muscle mitochondria in patients with type 2 diabetes (T2D) is heavily disputed. Thus, the purpose this investigation was to characterize mitochondrial phenotypes across insulin resistance spectrum. Methods: 30 sedentary adults aged 18-55 were grouped as lean (BMI 21±0.6, N=13), obese 32±0.9, N=12), or T2D 33±2.5, N=5) based on oral glucose tolerance tests body mass index (BMI). All subjects completed a 3-day,...
The tumor microenvironment (TME) is characterized by deficiencies in oxygen and key nutrients, such as glucose amino acids, resulting an overall immune-suppressive environment. Key suppressive cell types the TME include tumor, stromal myeloid-derived suppressor cells (MDSC) which create a nutrient-poor environment that supports growth limits immune surveillance. General control nonderepressible 2 (GCN2), stress response kinase, plays role sensing modulating cellular to acid deprivation. GCN2...