A5007478668- Cardiovascular Effects of Exercise
- Cardiac pacing and defibrillation studies
- Family and Patient Care in Intensive Care Units
- Cardiomyopathy and Myosin Studies
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrest and Resuscitation
- Mental Health and Patient Involvement
- Cancer Cells and Metastasis
- BRCA gene mutations in cancer
- Genomics and Rare Diseases
- Adolescent and Pediatric Healthcare
- Heart Failure Treatment and Management
- Genetic factors in colorectal cancer
- Employment and Welfare Studies
- Law, AI, and Intellectual Property
- Suicide and Self-Harm Studies
- CRISPR and Genetic Engineering
- Workplace Health and Well-being
- Digital Media and Visual Art
- Microtubule and mitosis dynamics
- PARP inhibition in cancer therapy
- Phagocytosis and Immune Regulation
- Patient-Provider Communication in Healthcare
- Cardiovascular Function and Risk Factors
- Cardiac Health and Mental Health
Monash University
2024-2025
Duke University Hospital
2025
Hudson Institute of Medical Research
2024
Garvan Institute of Medical Research
2022-2023
UNSW Sydney
2020-2023
Murdoch Children's Research Institute
2022-2023
Centenary Institute
2020-2023
The University of Sydney
2020-2023
Background Patient and family satisfaction with care in intensive units is not reflected Hospital Consumer Assessment of Healthcare Providers Systems surveys. Gaps may be unknown. Local Problem In a cardiothoracic unit, patient scores were assessed gaps could addressed. The primary aim was to obtain baseline data on satisfaction. secondary improve identified Methods A preintervention-postintervention, 2-cycle quality improvement project 12-month sustainability assessment conducted evaluate...
Abstract Ovarian cancer (OC) poses a significant clinical challenge due to its high recurrence rates and resistance standard therapies, particularly in advanced stages where is common, treatment predominantly palliative. Personalized treatments, while effective other cancers, remain underutilized OC lack of reliable biomarkers predicting outcomes. Accordingly, precision medicine approaches are limited, with PARP inhibitors showing efficacy only specific genetic contexts. Drug repurposing...
Abstract The complexity of genetic variant interpretation means that a proportion individuals who undergo testing for hereditary cancer syndrome will have their test result reclassified over time. Such reclassification may involve clinically significant upgrade or downgrade in pathogenicity, which implications medical management. To date, few studies examined the psychosocial impact context. address this gap, semi-structured telephone interviews were performed with eighteen had BRCA1 , BRCA2...
Objective To codesign an online support intervention for families after sudden cardiac death (SCD) in the young (<35 years). Design Codesign of SCD family by stakeholder focus groups. Setting Families and healthcare professionals with experience young. Participants Semistructured groups were held key stakeholders, that is, members who had experienced SCD, researchers based New South Wales, Australia. Guided discussions used to develop intervention. Thematic analysis iterative feedback on...
Sudden cardiac death (SCD) is a devastating event for the family and community, especially when it occurs in young person (<45 years). Genetic heart diseases, including cardiomyopathies primary arrhythmia syndromes, are an important cause of SCD young. Although cardiogenetic evaluation, that is, clinical genetic testing, psychological support, increasingly performed after SCD, unknown how suddenly bereaved members experience process. We aimed to explore experiences with evaluation their...
Over 75% of patients with ovarian cancer present late-stage disease, often accompanied by extensive metastasis. The metastatic cascade is driven a sub-population transcriptionally plastic cells known as "leader cells" (LCs), which play critical role in collective invasion yet remain poorly understood. LCs are marked the expression keratin-14 (KRT14), determines their migratory and invasive capacity cancer. This study demonstrates that KRT14+ promote tumor progression through...
<sec> <title>BACKGROUND</title> Genetic heart diseases such as hypertrophic cardiomyopathy can cause significant morbidity and mortality, ranging from syncope, chest pain, palpitations to failure sudden cardiac death. These are inherited in an autosomal dominant fashion, meaning family members of affected individuals have a 1 2 chance also inheriting the disease (“at-risk relatives”). The health care use patterns with genetic disease, including emergency department presentations hospital...
Background Genetic heart diseases such as hypertrophic cardiomyopathy can cause significant morbidity and mortality, ranging from syncope, chest pain, palpitations to failure sudden cardiac death. These are inherited in an autosomal dominant fashion, meaning family members of affected individuals have a 1 2 chance also inheriting the disease (“at-risk relatives”). The health care use patterns with genetic disease, including emergency department presentations hospital admissions, poorly...
ABSTRACT Objective To develop content for the website component of COPE-SCD: an online community supporting families after sudden cardiac death (SCD) and assess its acceptability. Methods Based on topics from codesign focus groups, was drafted, readability language assessed. SCD family members were recruited Genetic Heart Disease Clinic, Royal Prince Alfred Hospital, Sydney. Demographic psychological measures collected at baseline. ‘Think aloud’ interviews conducted to with questions mapped...
ABSTRACT Purpose Thorough investigation of sudden cardiac death (SCD) in those aged 1-40 years commonly reveals a heritable cause, yet access to postmortem genetic testing is variable. We explore practices and attitudes healthcare professionals worldwide. Methods A survey was administered among recruited through professional associations, social media networks researchers. Topics included around testing, level confidence professionals’ ability, towards practices. Results There were 112...
ABSTRACT Introduction Sudden cardiac death (SCD) is a devastating event for the family and community, especially when it occurs in young person (<45 years). Genetic heart diseases, including cardiomyopathies primary arrhythmia syndromes, are an important cause of SCD young. Although cardiogenetic evaluation, i.e., clinical genetic testing psychological support, increasingly performed after SCD, unknown how suddenly bereaved members experience process. We aimed to explore experiences with...
ABSTRACT Objective To co-design an online support intervention for families after sudden cardiac death (SCD) in the young (<35 years). Design Co-design of a SCD family by stakeholder focus groups. Setting Families and healthcare professionals with experience young. Participants Semi-structured groups were held key stakeholders, i.e. members who had experienced SCD, researchers. Guided discussions used to develop intervention. Thematic analysis iterative feedback on draft materials guided...