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Jennifer Castro

ORCID: 0009-0007-5718-2692
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A5109694340
Research Areas
  • Science, Research, and Medicine
  • RNA and protein synthesis mechanisms
  • RNA Research and Splicing
  • Biotechnology and Related Fields
  • Steroid Chemistry and Biochemistry
  • RNA modifications and cancer
  • Genetic factors in colorectal cancer
  • DNA and Nucleic Acid Chemistry
  • Animal Genetics and Reproduction
  • DNA Repair Mechanisms
  • Lung Cancer Research Studies
  • Peptidase Inhibition and Analysis
  • Ubiquitin and proteasome pathways
  • Organic Chemistry Cycloaddition Reactions
  • bioluminescence and chemiluminescence research
  • Circular RNAs in diseases
  • Reproductive System and Pregnancy
  • Cytokine Signaling Pathways and Interactions
  • Healthcare Policy and Management
  • Advanced Causal Inference Techniques
  • Attachment and Relationship Dynamics
  • Perfectionism, Procrastination, Anxiety Studies
  • Genetics and Neurodevelopmental Disorders
  • Biochemical and Molecular Research
  • Synthesis and Biological Evaluation

Accent Therapeutics (United States)
 2023-2025

Rutgers Sexual and Reproductive Health and Rights
 2017

 Supplementary Data Table 3 from A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
OPENALEX - Publications 
Jennifer Castro Matthew H. Daniels David Brennan Brian Johnston Deepali Gotur and 19 more Young‐Tae Lee Kevin E. Knockenhauer Chuang Lu Jie Wu Sunaina Nayak Cindy Collins Rishabh Bansal Shane M. Buker April Case Julie Liu Shihua Yao Brian A. Sparling E. Allen Sickmier Serena J. Silver Stephen J. Blakemore P. Ann Boriack‐Sjodin Kenneth W. Duncan Scott Ribich Robert A. Copeland

<p>Supplementary Data Table 3</p>

10.1158/0008-5472.28431561 preprint EN cc-by 2025-02-17
 Supplementary Data Figure 5 from A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
OPENALEX - Publications 
Jennifer Castro Matthew H. Daniels David Brennan Brian Johnston Deepali Gotur and 19 more Young‐Tae Lee Kevin E. Knockenhauer Chuang Lu Jie Wu Sunaina Nayak Cindy Collins Rishabh Bansal Shane M. Buker April Case Julie Liu Shihua Yao Brian A. Sparling E. Allen Sickmier Serena J. Silver Stephen J. Blakemore P. Ann Boriack‐Sjodin Kenneth W. Duncan Scott Ribich Robert A. Copeland

<p>Supplementary Data Figure 5</p>

10.1158/0008-5472.28431579 preprint EN cc-by 2025-02-17
 Supplementary Data Table 2 from A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
OPENALEX - Publications 
Jennifer Castro Matthew H. Daniels David Brennan Brian Johnston Deepali Gotur and 19 more Young‐Tae Lee Kevin E. Knockenhauer Chuang Lu Jie Wu Sunaina Nayak Cindy Collins Rishabh Bansal Shane M. Buker April Case Julie Liu Shihua Yao Brian A. Sparling E. Allen Sickmier Serena J. Silver Stephen J. Blakemore P. Ann Boriack‐Sjodin Kenneth W. Duncan Scott Ribich Robert A. Copeland

<p>Supplementary Data Table 2</p>

10.1158/0008-5472.28431564 preprint EN cc-by 2025-02-17
 Supplementary Data Table 4 from A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
OPENALEX - Publications 
Jennifer Castro Matthew H. Daniels David Brennan Brian Johnston Deepali Gotur and 19 more Young‐Tae Lee Kevin E. Knockenhauer Chuang Lu Jie Wu Sunaina Nayak Cindy Collins Rishabh Bansal Shane M. Buker April Case Julie Liu Shihua Yao Brian A. Sparling E. Allen Sickmier Serena J. Silver Stephen J. Blakemore P. Ann Boriack‐Sjodin Kenneth W. Duncan Scott Ribich Robert A. Copeland

<p>Supplementary Data Table 4</p>

10.1158/0008-5472.28431555 preprint EN cc-by 2025-02-17
 Supplementary Data Figure 2 from A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
OPENALEX - Publications 
Jennifer Castro Matthew H. Daniels David Brennan Brian Johnston Deepali Gotur and 19 more Young‐Tae Lee Kevin E. Knockenhauer Chuang Lu Jie Wu Sunaina Nayak Cindy Collins Rishabh Bansal Shane M. Buker April Case Julie Liu Shihua Yao Brian A. Sparling E. Allen Sickmier Serena J. Silver Stephen J. Blakemore P. Ann Boriack‐Sjodin Kenneth W. Duncan Scott Ribich Robert A. Copeland

<p>Supplementary Data Figure 2</p>

10.1158/0008-5472.28431588 preprint EN cc-by 2025-02-17
 Supplementary Data Figure 7 from A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
OPENALEX - Publications 
Jennifer Castro Matthew H. Daniels David Brennan Brian Johnston Deepali Gotur and 19 more Young‐Tae Lee Kevin E. Knockenhauer Chuang Lu Jie Wu Sunaina Nayak Cindy Collins Rishabh Bansal Shane M. Buker April Case Julie Liu Shihua Yao Brian A. Sparling E. Allen Sickmier Serena J. Silver Stephen J. Blakemore P. Ann Boriack‐Sjodin Kenneth W. Duncan Scott Ribich Robert A. Copeland

<p>Supplementary Data Figure 7</p>

10.1158/0008-5472.28431570 preprint EN cc-by 2025-02-17
 Data from A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
OPENALEX - Publications 
Jennifer Castro Matthew H. Daniels David Brennan Brian Johnston Deepali Gotur and 19 more Young‐Tae Lee Kevin E. Knockenhauer Chuang Lu Jie Wu Sunaina Nayak Cindy Collins Rishabh Bansal Shane M. Buker April Case Julie Liu Shihua Yao Brian A. Sparling E. Allen Sickmier Serena J. Silver Stephen J. Blakemore P. Ann Boriack‐Sjodin Kenneth W. Duncan Scott Ribich Robert A. Copeland

<div>Abstract<p>DHX9 is a multifunctional DExH-box RNA helicase with important roles in the regulation of transcription, translation, and maintenance genome stability. Elevated expression DHX9 evident multiple cancer types, including colorectal cancer. Microsatellite instable–high (MSI-H) tumors deficient mismatch repair (dMMR) display strong dependence on DHX9, making this an attractive target for oncology drug discovery. In report, we show that knockdown increased RNA/DNA...

10.1158/0008-5472.c.7676181 preprint EN 2025-02-17
 Supplementary Data Figure 6 from A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
OPENALEX - Publications 
Jennifer Castro Matthew H. Daniels David Brennan Brian Johnston Deepali Gotur and 19 more Young‐Tae Lee Kevin E. Knockenhauer Chuang Lu Jie Wu Sunaina Nayak Cindy Collins Rishabh Bansal Shane M. Buker April Case Julie Liu Shihua Yao Brian A. Sparling E. Allen Sickmier Serena J. Silver Stephen J. Blakemore P. Ann Boriack‐Sjodin Kenneth W. Duncan Scott Ribich Robert A. Copeland

<p>Supplementary Data Figure 6</p>

10.1158/0008-5472.28431573 preprint EN cc-by 2025-02-17
 Supplementary Data Figure 3 from A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
OPENALEX - Publications 
Jennifer Castro Matthew H. Daniels David Brennan Brian Johnston Deepali Gotur and 19 more Young‐Tae Lee Kevin E. Knockenhauer Chuang Lu Jie Wu Sunaina Nayak Cindy Collins Rishabh Bansal Shane M. Buker April Case Julie Liu Shihua Yao Brian A. Sparling E. Allen Sickmier Serena J. Silver Stephen J. Blakemore P. Ann Boriack‐Sjodin Kenneth W. Duncan Scott Ribich Robert A. Copeland

<p>Supplementary Data Figure 3</p>

10.1158/0008-5472.28431585 preprint EN cc-by 2025-02-17
 Supplementary Data Figure 1 from A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
OPENALEX - Publications 
Jennifer Castro Matthew H. Daniels David Brennan Brian Johnston Deepali Gotur and 19 more Young‐Tae Lee Kevin E. Knockenhauer Chuang Lu Jie Wu Sunaina Nayak Cindy Collins Rishabh Bansal Shane M. Buker April Case Julie Liu Shihua Yao Brian A. Sparling E. Allen Sickmier Serena J. Silver Stephen J. Blakemore P. Ann Boriack‐Sjodin Kenneth W. Duncan Scott Ribich Robert A. Copeland

<p>Supplementary Data Figure 1</p>

10.1158/0008-5472.28431591 preprint EN cc-by 2025-02-17
 Supplementary Data Figure 4 from A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
OPENALEX - Publications 
Jennifer Castro Matthew H. Daniels David Brennan Brian Johnston Deepali Gotur and 19 more Young‐Tae Lee Kevin E. Knockenhauer Chuang Lu Jie Wu Sunaina Nayak Cindy Collins Rishabh Bansal Shane M. Buker April Case Julie Liu Shihua Yao Brian A. Sparling E. Allen Sickmier Serena J. Silver Stephen J. Blakemore P. Ann Boriack‐Sjodin Kenneth W. Duncan Scott Ribich Robert A. Copeland

<p>Supplementary Data Figure 4</p>

10.1158/0008-5472.28431582 preprint EN cc-by 2025-02-17
 Supplementary Data Table 1 from A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
OPENALEX - Publications 
Jennifer Castro Matthew H. Daniels David Brennan Brian Johnston Deepali Gotur and 19 more Young‐Tae Lee Kevin E. Knockenhauer Chuang Lu Jie Wu Sunaina Nayak Cindy Collins Rishabh Bansal Shane M. Buker April Case Julie Liu Shihua Yao Brian A. Sparling E. Allen Sickmier Serena J. Silver Stephen J. Blakemore P. Ann Boriack‐Sjodin Kenneth W. Duncan Scott Ribich Robert A. Copeland

<p>Supplementary Data Table 1</p>

10.1158/0008-5472.28431567 preprint EN cc-by 2025-02-17
 Supplementary Data Figure 5 from A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
OPENALEX - Publications 
Jennifer Castro Matthew H. Daniels David Brennan Brian Johnston Deepali Gotur and 19 more Young‐Tae Lee Kevin E. Knockenhauer Chuang Lu Jie Wu Sunaina Nayak Cindy Collins Rishabh Bansal Shane M. Buker April Case Julie Liu Shihua Yao Brian A. Sparling E. Allen Sickmier Serena J. Silver Stephen J. Blakemore P. Ann Boriack‐Sjodin Kenneth W. Duncan Scott Ribich Robert A. Copeland

<p>Supplementary Data Figure 5</p>

10.1158/0008-5472.28428306 preprint EN cc-by 2025-02-17
 Supplementary Data Figure 1 from A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
OPENALEX - Publications 
Jennifer Castro Matthew H. Daniels David Brennan Brian Johnston Deepali Gotur and 19 more Young‐Tae Lee Kevin E. Knockenhauer Chuang Lu Jie Wu Sunaina Nayak Cindy Collins Rishabh Bansal Shane M. Buker April Case Julie Liu Shihua Yao Brian A. Sparling E. Allen Sickmier Serena J. Silver Stephen J. Blakemore P. Ann Boriack‐Sjodin Kenneth W. Duncan Scott Ribich Robert A. Copeland

<p>Supplementary Data Figure 1</p>

10.1158/0008-5472.28428321 preprint EN cc-by 2025-02-17
 Supplementary Data Table 4 from A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
OPENALEX - Publications 
Jennifer Castro Matthew H. Daniels David Brennan Brian Johnston Deepali Gotur and 19 more Young‐Tae Lee Kevin E. Knockenhauer Chuang Lu Jie Wu Sunaina Nayak Cindy Collins Rishabh Bansal Shane M. Buker April Case Julie Liu Shihua Yao Brian A. Sparling E. Allen Sickmier Serena J. Silver Stephen J. Blakemore P. Ann Boriack‐Sjodin Kenneth W. Duncan Scott Ribich Robert A. Copeland

<p>Supplementary Data Table 4</p>

10.1158/0008-5472.28428288 preprint EN cc-by 2025-02-17
 Supplementary Data Table 2 from A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
OPENALEX - Publications 
Jennifer Castro Matthew H. Daniels David Brennan Brian Johnston Deepali Gotur and 19 more Young‐Tae Lee Kevin E. Knockenhauer Chuang Lu Jie Wu Sunaina Nayak Cindy Collins Rishabh Bansal Shane M. Buker April Case Julie Liu Shihua Yao Brian A. Sparling E. Allen Sickmier Serena J. Silver Stephen J. Blakemore P. Ann Boriack‐Sjodin Kenneth W. Duncan Scott Ribich Robert A. Copeland

<p>Supplementary Data Table 2</p>

10.1158/0008-5472.28428294 preprint EN cc-by 2025-02-17
 Supplementary Data Table 3 from A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
OPENALEX - Publications 
Jennifer Castro Matthew H. Daniels David Brennan Brian Johnston Deepali Gotur and 19 more Young‐Tae Lee Kevin E. Knockenhauer Chuang Lu Jie Wu Sunaina Nayak Cindy Collins Rishabh Bansal Shane M. Buker April Case Julie Liu Shihua Yao Brian A. Sparling E. Allen Sickmier Serena J. Silver Stephen J. Blakemore P. Ann Boriack‐Sjodin Kenneth W. Duncan Scott Ribich Robert A. Copeland

<p>Supplementary Data Table 3</p>

10.1158/0008-5472.28428291 preprint EN cc-by 2025-02-17
 Supplementary Data Figure 7 from A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
OPENALEX - Publications 
Jennifer Castro Matthew H. Daniels David Brennan Brian Johnston Deepali Gotur and 19 more Young‐Tae Lee Kevin E. Knockenhauer Chuang Lu Jie Wu Sunaina Nayak Cindy Collins Rishabh Bansal Shane M. Buker April Case Julie Liu Shihua Yao Brian A. Sparling E. Allen Sickmier Serena J. Silver Stephen J. Blakemore P. Ann Boriack‐Sjodin Kenneth W. Duncan Scott Ribich Robert A. Copeland

<p>Supplementary Data Figure 7</p>

10.1158/0008-5472.28428300 preprint EN cc-by 2025-02-17
 Supplementary Data Figure 3 from A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
OPENALEX - Publications 
Jennifer Castro Matthew H. Daniels David Brennan Brian Johnston Deepali Gotur and 19 more Young‐Tae Lee Kevin E. Knockenhauer Chuang Lu Jie Wu Sunaina Nayak Cindy Collins Rishabh Bansal Shane M. Buker April Case Julie Liu Shihua Yao Brian A. Sparling E. Allen Sickmier Serena J. Silver Stephen J. Blakemore P. Ann Boriack‐Sjodin Kenneth W. Duncan Scott Ribich Robert A. Copeland

<p>Supplementary Data Figure 3</p>

10.1158/0008-5472.28428315 preprint EN cc-by 2025-02-17
 Supplementary Data Figure 2 from A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
OPENALEX - Publications 
Jennifer Castro Matthew H. Daniels David Brennan Brian Johnston Deepali Gotur and 19 more Young‐Tae Lee Kevin E. Knockenhauer Chuang Lu Jie Wu Sunaina Nayak Cindy Collins Rishabh Bansal Shane M. Buker April Case Julie Liu Shihua Yao Brian A. Sparling E. Allen Sickmier Serena J. Silver Stephen J. Blakemore P. Ann Boriack‐Sjodin Kenneth W. Duncan Scott Ribich Robert A. Copeland

<p>Supplementary Data Figure 2</p>

10.1158/0008-5472.28428318 preprint EN cc-by 2025-02-17
 Supplementary Data Table 1 from A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
OPENALEX - Publications 
Jennifer Castro Matthew H. Daniels David Brennan Brian Johnston Deepali Gotur and 19 more Young‐Tae Lee Kevin E. Knockenhauer Chuang Lu Jie Wu Sunaina Nayak Cindy Collins Rishabh Bansal Shane M. Buker April Case Julie Liu Shihua Yao Brian A. Sparling E. Allen Sickmier Serena J. Silver Stephen J. Blakemore P. Ann Boriack‐Sjodin Kenneth W. Duncan Scott Ribich Robert A. Copeland

<p>Supplementary Data Table 1</p>

10.1158/0008-5472.28428297 preprint EN cc-by 2025-02-17
 Supplementary Data Figure 6 from A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
OPENALEX - Publications 
Jennifer Castro Matthew H. Daniels David Brennan Brian Johnston Deepali Gotur and 19 more Young‐Tae Lee Kevin E. Knockenhauer Chuang Lu Jie Wu Sunaina Nayak Cindy Collins Rishabh Bansal Shane M. Buker April Case Julie Liu Shihua Yao Brian A. Sparling E. Allen Sickmier Serena J. Silver Stephen J. Blakemore P. Ann Boriack‐Sjodin Kenneth W. Duncan Scott Ribich Robert A. Copeland

<p>Supplementary Data Figure 6</p>

10.1158/0008-5472.28428303 preprint EN cc-by 2025-02-17
 Supplementary Data Figure 4 from A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
OPENALEX - Publications 
Jennifer Castro Matthew H. Daniels David Brennan Brian Johnston Deepali Gotur and 19 more Young‐Tae Lee Kevin E. Knockenhauer Chuang Lu Jie Wu Sunaina Nayak Cindy Collins Rishabh Bansal Shane M. Buker April Case Julie Liu Shihua Yao Brian A. Sparling E. Allen Sickmier Serena J. Silver Stephen J. Blakemore P. Ann Boriack‐Sjodin Kenneth W. Duncan Scott Ribich Robert A. Copeland

<p>Supplementary Data Figure 4</p>

10.1158/0008-5472.28428312 preprint EN cc-by 2025-02-17
 Abstract 1758: ATX-559, a first in class DHX9 inhibitor, and targeted therapeutic for molecularly defined tumors with genomic instability and replicative stress
OPENALEX - Publications 
Jennifer Castro Matthew H. Daniels Sunaina Nayak David Brennan Cindy Collins and 17 more Sophie A. Shen Monique Laidlaw Jie Wu Anugraha Raman Deepali Gotur Kevin E. Knockenhauer Shihua Yao Simina Grigoriu G.J. Lockbaum Kate J. Newberry Stephen J. Blakemore P. Ann Boriack‐Sjodin Kenneth W. Duncan Stuart Ince Jason A. Sager Robert A. Copeland Serena J. Silver

Abstract DHX9, a multi-functional RNA helicase, contributes to genome stability by unwinding nucleic acid secondary structures, including DNA/RNA hybrids (R-loops), circular and G-quadruplexes. Multiple cancer types exhibit increased expression of selective dependance DHX9 has been observed in molecular defined tumors that genomic instability. These often have elevated replicative stress due rapid unregulated proliferation defective DNA damage repair (DDRD) pathways; inhibition these further...

10.1158/1538-7445.am2025-1758 article EN Cancer Research 2025-04-21
 Abstract 6128: Targeting DHX9 helicase with the novel small-molecule inhibitor ATX968 induces replication stress and innate immunity in small cell lung cancer
OPENALEX - Publications 
Takahiko Murayama Jun Nakayama Xueying Ma Siddharth Balachandran Matthew H. Daniels and 2 more Jennifer Castro Israel Cañadas

Abstract Small cell lung cancer (SCLC) is the most lethal type of cancer. The uniqueness this tumor lies in its initial exquisite response to chemotherapy, due high level genomic instability. However, patients experience relapse within 6 12 months. Although addition immune checkpoint blockade (ICB) therapy standard chemotherapy has been approved by FDA, only a small fraction SCLC responds immunotherapy because an immunologically “cold” microenvironment. Recently, using genetic depletion...

10.1158/1538-7445.am2025-6128 article EN Cancer Research 2025-04-21
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