A5021869301- Retinoids in leukemia and cellular processes
- Phytochemical Studies and Bioactivities
- Microbial Metabolism and Applications
- Natural Products and Applications
- Ubiquitin and proteasome pathways
- Herbal Medicine and Trade Cooperation
- Cancer-related Molecular Pathways
Universitas Gadjah Mada
2021-2023
We aim to enhance the effectiveness of curcumin analog PGV-1 through co-treatment with diosmin, a citrus flavonoid, on 4T1 cells and evaluate molecular targets underlying its effect cell cycle.Cytotoxic effects were performed by MTT assay against cells. The May Grünwald-Giemsa staining was used observe cycle arrest. senescence assayed SA-ß-gal staining. Bioinformatic studies utilized discover protein diosmin triple-negative breast cancer (TNBC) using SwissTargetPrediction, then exploration...
Pentagamavunone-1 (PGV-1) is a curcumin analog with prominent anti-cancer potency in vitro and vivo for several cancer types, including colon cancer. Combining PGV-1 natural compounds such as diosmin, galangin, piperine can enhance its effectiveness due to their promising chemoprevention properties. We aimed evaluate the of combining or by using bioinformatic approaches predict target proteins. WiDr cells were used model adenocarcinoma (COAD). The cell viability under single combination...
Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri senyawa 5,7-dihidroksiflavanon dari ekstrak ethanol Temu Kunci (Boesenbergia pandurata) terhadap bakteri Escherichia coli ATCC 11229 dan Staphylococcus epidermidis FNCC 0048 serta konsentrasi yang memiliki optimum kedua bakteri. Uji dilakukan dengan metode difusi agar paper disc (Kirby Bauer). Aktivitas dibuktikan adanya zona hambat bening di sekitar disc. Konsentrasi digunakan dalam penelitian yaitu 0,5 ppm, 5 50 250 500 ppm....