Acetoxychavicol acetate (ACA) is a promising natural compound with an extensive spectrum of medicinal properties. This study aimed to provide bibliometric mapping evaluate the ACA trends in publishing and original research. We conducted targeted search on Scopus database for relevant literature examined acquired data using VOSviewer determine citation keyword patterns. A total 135 articles were examined. Over several years, research has revealed fluctuating pattern. Currently, Japan Malaysia...

Pentagamavunon-1 performs more potent anti-cancer effects than curcumin against various cancer cells, but it remains to be optimized. Piperine shows the activity as an enhancer of a therapeutic agent. This study expects achieve higher effectiveness PGV-1 on 4T1 breast cells through co-treatment with piperine exploring effect cytotoxicity, mitotic catastrophe, cellular senescence, and target proteins regulation mitosis in TNBC (4T1). The assays emphasize MTT assay, May Grünwald-Giemsa...

We aim to enhance the effectiveness of curcumin analog PGV-1 through co-treatment with diosmin, a citrus flavonoid, on 4T1 cells and evaluate molecular targets underlying its effect cell cycle.Cytotoxic effects were performed by MTT assay against cells. The May Grünwald-Giemsa staining was used observe cycle arrest. senescence assayed SA-ß-gal staining. Bioinformatic studies utilized discover protein diosmin triple-negative breast cancer (TNBC) using SwissTargetPrediction, then exploration...

Purpose: This study aimed to challenge the anticancer potency of pentagamavunone-1 (PGV-1) and obtain a new compound (Chemoprevention-Curcumin Analog 1.1, CCA-1.1) withimproved chemical pharmacological properties.Methods: CCA-1.1 was prepared by changing ketone group PGV-1 into hydroxylgroup with NaBH4 as reducing agent. The product purified under preparative layerchromatography confirmed HPLC show about 93% purity. It tested for itssolubility, stability, cytotoxic activities on several...

Triple-negative breast cancer (TNBC) remains as the deadliest type due to lack of treatment options. Hence, several attempts have been made develop new anticancer for TNBC therapy. This study intended challenge curcumin analog (CCA)-1.1, which is derived from pentagamavunone-1 structure, against 4T1 cell line and model, covering cytotoxic activity in correlation with cycle progression, apoptosis induction, reactive oxygen species (ROS) generation, senescence evidence. The viability, profile,...

This study aimed to evaluate the efficacy of Chemoprevention Curcumin Analog-1.1 (CCA-1.1) and Pentagamavunone-1 (PGV-1) in vivo vitro colorectal cancer model. CCA-1.1 or PGV-1 was administered orally 1,2-dimethylhydrazine (DMH)-induced rats for 16 weeks. The cytotoxicity both compounds tested on Caco-2, CT26, NIH/3T3 cells using MTT method. cell cycle, apoptosis, reactive oxygen species (ROS) levels were analyzed through flow cytometry. X-gal staining used examine compound's effect...

An improved compound of pentagamavunone-1 (PGV-1), chemoprevention-curcumin analog 1.1 (CCA-1.1), has been synthesized and proven to have antiproliferative effects against breast cancer cells. This study is designed investigate the potency CCA-1.1 alone in combination with doxorubicin (Dox) on T47D cells comparison that PGV-1. We used MTT assay assess cytotoxic activity. Propidium iodide (PI), annexin-V–PI, DCFDA staining were respectively determine cell cycle profiles, apoptosis,...

To evaluate the anti-cancer properties of Caesalpinia sappan and Ficus septica in combination with doxorubicin on 4T1 cells, confirm their nephroprotective activities, predict molecular targets underlying mechanisms.The cytotoxic activities all extracts were determined by MTT assay followed cell cycle apoptosis analysis using flow cytometry. Immunoblotting was used to determine protein expressions. The proteins involved proliferation migration analyzed through bioinformatics approaches,...

Abstract The treatment of glioblastoma multiforme (GBM) is challenging owing to its localization in the brain, limited capacity brain cells repair, resistance conventional therapy, and aggressiveness. Curcumin has anticancer activity against aggressive cancers, such as leukemia, GBM; however, application by low solubility bioavailability. Chemoprevention curcumin analog 1.1 (CCA-1.1), a analog, better stability than those curcumin. In this study, we explored potential targets CCA-1.1 GBM...

ZnO nanoparticles: Crosslink between cytotoxicity on liver cell lines and In Vivo biosafety different mice organsNahla Nabil Kamel, Maha Zaki Rizk, Walaa Gamal Hozayen, Abdel-Hamid

The Analgesic Effect of a Curcumin Analogue 1,5-bis(4’-hydroxy-3’-methoxyphenyl)-1,4-pentadien-3-on (Gamavuton-0) in acute and persistent painZullies Ikawati, Nunung Yuniarti, Supardjan Amir Margono

The new Pentagamavunone-1 (PGV-1) derivative, chemoprevention-curcumin analog 1.1 (CCA-1.1), is described as an improved physicochemical feature with similar cytotoxic activity on colon cancer cells and binding interaction to various biomarkers.The current study explored the related its ability promote physiological changes in WiDr cell line.The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was used assess viability of NIH-3T3 treatment CCA-1.1...

BACKGROUND: Colon cancer is still a crucial concern in the development of chemotherapeutic drugs due to drug resistance phenomenon and various side effects patients. One newest compound that show anticancer activities against several cells, Chemoprevention Curcumin Analog 1 (CCA-1.1), has increasingly been explored overcome limitation conventional drugs.METHODS: We evaluated anti-migratory effect CCA-1.1 Pentagamavunone-1 (PGV-1) by using WiDr colon cells. The expression profiles Tumor...

Boronic acid-containing curcumin analog, pentagamaboronon-0 (PGB-0), acts as a potential boron-carrier agent but has limited water solubility. Thus, new compound (PGB-0-ol) with better chemical and pharmacological properties than PGB-0 been synthesized. Molecular docking was performed using molecular operating environment. Prediction of PGB-0-ol absorption, distribution, metabolism, excretion (ADME) pkCSM software. synthesized by adding NaBH

Background: Lactate dehydrogenase B (LDHB), a typical oxidoreductase for converting lactate to pyruvate in the glycolysis process, takes complex function progression of cancer cells. Even so, profile LDHB relevance colon adenocarcinoma (COAD) remains ambiguous. Hence this study analyzed expression and co-expression LDHB, its immune correlation COAD.Materials method: The mRNA COAD were retrieved from UALCAN. infiltration levels cells, CD4+ T CD8+ macrophages, neutrophils, dendritic cells...

Monoclonal antibodies and targeted therapies against HER2+ breast cancer has improved overall disease-free survival in patients; however, encountering drug resistance causes recurrence, necessitating the development of newer HER2-targeted medications. A curcumin analog PGB-0-ol showed most cytotoxicity HCC1954 cells than other subtypes cells.Here, we employed next-generation sequencing technology to elucidate molecular mechanism underlying effect on cells.The action was determined using...

Pentagamavunon-1 (PGV-1), a potential chemopreventive agent with strong cytotoxic effect, modulates prometaphase arrest. Improvement to get higher effectiveness of PGV-1 is new challenge. A previous study reported that the natural compound, galangin, has antiproliferative activity against cancer cells lower cytotoxicity effect. This aims develop combinatorial treatment and galangin as an anticancer than single agent. In this study, 4T1, TNBC model cell, was treated combination galangin. As...

Pentagamavunone-1 (PGV-1) is a curcumin analog with prominent anti-cancer potency in vitro and vivo for several cancer types, including colon cancer. Combining PGV-1 natural compounds such as diosmin, galangin, piperine can enhance its effectiveness due to their promising chemoprevention properties. We aimed evaluate the of combining or by using bioinformatic approaches predict target proteins. WiDr cells were used model adenocarcinoma (COAD). The cell viability under single combination...

Fear of failure is an emotional reaction that causes fear when in a situation might cause failure. The phenomenon can be related to mindfulness, where mindfulness reduce This study aims determine the relationship between and students who are working on thesis at Padang State University. uses correlational quantitative research design. targets this were University using proportional sampling technique totalling 236 people. measuring instrument used Kentucky Inventory Mindfulness Skills (KIMS)...

Fear of failure is an emotional reaction that causes fear when in a situation might cause failure. The phenomenon can be related to mindfulness, where mindfulness reduce This study aims determine the relationship between and students who are working on thesis at Padang State University. uses correlational quantitative research design. targets this were University using proportional sampling technique totalling 236 people. measuring instrument used Kentucky Inventory Mindfulness Skills (KIMS)...

Class 1 and 2 histone deacetylase inhibitors (HDACI) have been reported as novel therapeutic approaches to treat neurodegenerative disorders, depression, anxiety, cognitive deficits. HDACI ameliorated deficits in cognition stress-related behaviors a wide range of neurologic psychiatric disorders. Preclinically, behavioral bioassay can be used predict the influence new compounds for treatment these illnesses. Curcumin its analogues PGV-0 PGV-1 inhibit HDAC2. However, reports regarding effect...