Febri Wulandari

ORCID: 0000-0002-0638-8240
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Research Areas
  • Biological Stains and Phytochemicals
  • Curcumin's Biomedical Applications
  • Cancer-related Molecular Pathways
  • Bioactive Natural Diterpenoids Research
  • Retinoids in leukemia and cellular processes
  • Phytochemical Studies and Bioactivities
  • Microbial Metabolism and Applications
  • Ginger and Zingiberaceae research
  • Nuclear Receptors and Signaling
  • Tannin, Tannase and Anticancer Activities
  • Education and Character Development
  • Medicinal Plant Research
  • Bioactive Compounds in Plants
  • Genetics and Neurodevelopmental Disorders
  • Inflammatory mediators and NSAID effects
  • Magnolia and Illicium research
  • Phytochemical compounds biological activities
  • Oxidative Organic Chemistry Reactions
  • Educational Methods and Outcomes
  • Radiopharmaceutical Chemistry and Applications
  • Cancer, Hypoxia, and Metabolism
  • Agricultural and Biological Research
  • Legal and Policy Analysis in Indonesia
  • Indonesian Legal and Regulatory Studies
  • Microbial Applications in Construction Materials

Muhammadiyah University of Surakarta
2023-2024

State University of Padang
2024

Universitas Gadjah Mada
2020-2023

University of Brawijaya
2020

Acetoxychavicol acetate (ACA) is a promising natural compound with an extensive spectrum of medicinal properties. This study aimed to provide bibliometric mapping evaluate the ACA trends in publishing and original research. We conducted targeted search on Scopus database for relevant literature examined acquired data using VOSviewer determine citation keyword patterns. A total 135 articles were examined. Over several years, research has revealed fluctuating pattern. Currently, Japan Malaysia...

10.7324/japs.2025.218090 article EN Journal of Applied Pharmaceutical Science 2025-01-01

Pentagamavunon-1 performs more potent anti-cancer effects than curcumin against various cancer cells, but it remains to be optimized. Piperine shows the activity as an enhancer of a therapeutic agent. This study expects achieve higher effectiveness PGV-1 on 4T1 breast cells through co-treatment with piperine exploring effect cytotoxicity, mitotic catastrophe, cellular senescence, and target proteins regulation mitosis in TNBC (4T1). The assays emphasize MTT assay, May Grünwald-Giemsa...

10.5812/ijpr.123820 article EN cc-by-nc Deleted Journal 2022-02-04

We aim to enhance the effectiveness of curcumin analog PGV-1 through co-treatment with diosmin, a citrus flavonoid, on 4T1 cells and evaluate molecular targets underlying its effect cell cycle.Cytotoxic effects were performed by MTT assay against cells. The May Grünwald-Giemsa staining was used observe cycle arrest. senescence assayed SA-ß-gal staining. Bioinformatic studies utilized discover protein diosmin triple-negative breast cancer (TNBC) using SwissTargetPrediction, then exploration...

10.31557/apjcp.2021.22.9.2929 article EN cc-by Asian Pacific Journal of Cancer Prevention 2021-09-01

Purpose: This study aimed to challenge the anticancer potency of pentagamavunone-1 (PGV-1) and obtain a new compound (Chemoprevention-Curcumin Analog 1.1, CCA-1.1) withimproved chemical pharmacological properties.Methods: CCA-1.1 was prepared by changing ketone group PGV-1 into hydroxylgroup with NaBH4 as reducing agent. The product purified under preparative layerchromatography confirmed HPLC show about 93% purity. It tested for itssolubility, stability, cytotoxic activities on several...

10.34172/apb.2022.063 article EN cc-by Advanced Pharmaceutical Bulletin 2021-07-04

Triple-negative breast cancer (TNBC) remains as the deadliest type due to lack of treatment options. Hence, several attempts have been made develop new anticancer for TNBC therapy. This study intended challenge curcumin analog (CCA)-1.1, which is derived from pentagamavunone-1 structure, against 4T1 cell line and model, covering cytotoxic activity in correlation with cycle progression, apoptosis induction, reactive oxygen species (ROS) generation, senescence evidence. The viability, profile,...

10.52711/0974-360x.2021.00760 article EN Research Journal of Pharmacy and Technology 2021-08-06

This study aimed to evaluate the efficacy of Chemoprevention Curcumin Analog-1.1 (CCA-1.1) and Pentagamavunone-1 (PGV-1) in vivo vitro colorectal cancer model. CCA-1.1 or PGV-1 was administered orally 1,2-dimethylhydrazine (DMH)-induced rats for 16 weeks. The cytotoxicity both compounds tested on Caco-2, CT26, NIH/3T3 cells using MTT method. cell cycle, apoptosis, reactive oxygen species (ROS) levels were analyzed through flow cytometry. X-gal staining used examine compound's effect...

10.4103/japtr.japtr_315_23 article EN cc-by-nc-sa Journal of Advanced Pharmaceutical Technology amp Research 2023-10-01

An improved compound of pentagamavunone-1 (PGV-1), chemoprevention-curcumin analog 1.1 (CCA-1.1), has been synthesized and proven to have antiproliferative effects against breast cancer cells. This study is designed investigate the potency CCA-1.1 alone in combination with doxorubicin (Dox) on T47D cells comparison that PGV-1. We used MTT assay assess cytotoxic activity. Propidium iodide (PI), annexin-V–PI, DCFDA staining were respectively determine cell cycle profiles, apoptosis,...

10.22146/ijp.681 article EN cc-by INDONESIAN JOURNAL OF PHARMACY 2020-12-07

To evaluate the anti-cancer properties of Caesalpinia sappan and Ficus septica in combination with doxorubicin on 4T1 cells, confirm their nephroprotective activities, predict molecular targets underlying mechanisms.The cytotoxic activities all extracts were determined by MTT assay followed cell cycle apoptosis analysis using flow cytometry. Immunoblotting was used to determine protein expressions. The proteins involved proliferation migration analyzed through bioinformatics approaches,...

10.31557/apjcp.2022.23.2.743 article EN cc-by Asian Pacific Journal of Cancer Prevention 2022-02-01

Abstract The treatment of glioblastoma multiforme (GBM) is challenging owing to its localization in the brain, limited capacity brain cells repair, resistance conventional therapy, and aggressiveness. Curcumin has anticancer activity against aggressive cancers, such as leukemia, GBM; however, application by low solubility bioavailability. Chemoprevention curcumin analog 1.1 (CCA-1.1), a analog, better stability than those curcumin. In this study, we explored potential targets CCA-1.1 GBM...

10.1038/s41598-022-18348-9 article EN cc-by Scientific Reports 2022-08-17

ZnO nanoparticles: Crosslink between cytotoxicity on liver cell lines and In Vivo biosafety different mice organsNahla Nabil Kamel, Maha Zaki Rizk, Walaa Gamal Hozayen, Abdel-Hamid

10.7324/japs.2023.131550 article EN Journal of Applied Pharmaceutical Science 2023-01-01

The Analgesic Effect of a Curcumin Analogue 1,5-bis(4’-hydroxy-3’-methoxyphenyl)-1,4-pentadien-3-on (Gamavuton-0) in acute and persistent painZullies Ikawati, Nunung Yuniarti, Supardjan Amir Margono

10.7324/japs.2020.102010 article EN Journal of Applied Pharmaceutical Science 2020-02-01

The new Pentagamavunone-1 (PGV-1) derivative, chemoprevention-curcumin analog 1.1 (CCA-1.1), is described as an improved physicochemical feature with similar cytotoxic activity on colon cancer cells and binding interaction to various biomarkers.The current study explored the related its ability promote physiological changes in WiDr cell line.The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was used assess viability of NIH-3T3 treatment CCA-1.1...

10.7324/japs.2021.1101014 article EN Journal of Applied Pharmaceutical Science 2021-01-01

BACKGROUND: Colon cancer is still a crucial concern in the development of chemotherapeutic drugs due to drug resistance phenomenon and various side effects patients. One newest compound that show anticancer activities against several cells, Chemoprevention Curcumin Analog 1 (CCA-1.1), has increasingly been explored overcome limitation conventional drugs.METHODS: We evaluated anti-migratory effect CCA-1.1 Pentagamavunone-1 (PGV-1) by using WiDr colon cells. The expression profiles Tumor...

10.18585/inabj.v13i3.1583 article EN cc-by-nc The Indonesian Biomedical Journal 2021-09-09

Boronic acid-containing curcumin analog, pentagamaboronon-0 (PGB-0), acts as a potential boron-carrier agent but has limited water solubility. Thus, new compound (PGB-0-ol) with better chemical and pharmacological properties than PGB-0 been synthesized. Molecular docking was performed using molecular operating environment. Prediction of PGB-0-ol absorption, distribution, metabolism, excretion (ADME) pkCSM software. synthesized by adding NaBH

10.4103/japtr.japtr_220_21 article EN cc-by-nc-sa Journal of Advanced Pharmaceutical Technology amp Research 2022-01-01

Background: Lactate dehydrogenase B (LDHB), a typical oxidoreductase for converting lactate to pyruvate in the glycolysis process, takes complex function progression of cancer cells. Even so, profile LDHB relevance colon adenocarcinoma (COAD) remains ambiguous. Hence this study analyzed expression and co-expression LDHB, its immune correlation COAD.Materials method: The mRNA COAD were retrieved from UALCAN. infiltration levels cells, CD4+ T CD8+ macrophages, neutrophils, dendritic cells...

10.21705/mcbs.v7i2.346 article EN cc-by-nc Molecular and Cellular Biomedical Sciences 2023-07-18

Monoclonal antibodies and targeted therapies against HER2+ breast cancer has improved overall disease-free survival in patients; however, encountering drug resistance causes recurrence, necessitating the development of newer HER2-targeted medications. A curcumin analog PGB-0-ol showed most cytotoxicity HCC1954 cells than other subtypes cells.Here, we employed next-generation sequencing technology to elucidate molecular mechanism underlying effect on cells.The action was determined using...

10.1016/j.jsps.2023.101847 article EN cc-by Saudi Pharmaceutical Journal 2023-10-27

Pentagamavunon-1 (PGV-1), a potential chemopreventive agent with strong cytotoxic effect, modulates prometaphase arrest. Improvement to get higher effectiveness of PGV-1 is new challenge. A previous study reported that the natural compound, galangin, has antiproliferative activity against cancer cells lower cytotoxicity effect. This aims develop combinatorial treatment and galangin as an anticancer than single agent. In this study, 4T1, TNBC model cell, was treated combination galangin. As...

10.3390/scipharm89030038 article EN cc-by Scientia Pharmaceutica 2021-08-10

Pentagamavunone-1 (PGV-1) is a curcumin analog with prominent anti-cancer potency in vitro and vivo for several cancer types, including colon cancer. Combining PGV-1 natural compounds such as diosmin, galangin, piperine can enhance its effectiveness due to their promising chemoprevention properties. We aimed evaluate the of combining or by using bioinformatic approaches predict target proteins. WiDr cells were used model adenocarcinoma (COAD). The cell viability under single combination...

10.22146/jtbb.80975 article EN cc-by-sa Journal of Tropical Biodiversity and Biotechnology 2023-06-23

Fear of failure is an emotional reaction that causes fear when in a situation might cause failure. The phenomenon can be related to mindfulness, where mindfulness reduce This study aims determine the relationship between and students who are working on thesis at Padang State University. uses correlational quantitative research design. targets this were University using proportional sampling technique totalling 236 people. measuring instrument used Kentucky Inventory Mindfulness Skills (KIMS)...

10.62260/intrend.v2i1.108 article EN other-oa Deleted Journal 2024-02-22

Fear of failure is an emotional reaction that causes fear when in a situation might cause failure. The phenomenon can be related to mindfulness, where mindfulness reduce This study aims determine the relationship between and students who are working on thesis at Padang State University. uses correlational quantitative research design. targets this were University using proportional sampling technique totalling 236 people. measuring instrument used Kentucky Inventory Mindfulness Skills (KIMS)...

10.62260/intrend.v1i2.108 article EN cc-by Deleted Journal 2024-02-22

Class 1 and 2 histone deacetylase inhibitors (HDACI) have been reported as novel therapeutic approaches to treat neurodegenerative disorders, depression, anxiety, cognitive deficits. HDACI ameliorated deficits in cognition stress-related behaviors a wide range of neurologic psychiatric disorders. Preclinically, behavioral bioassay can be used predict the influence new compounds for treatment these illnesses. Curcumin its analogues PGV-0 PGV-1 inhibit HDAC2. However, reports regarding effect...

10.24071/jpsc.009660 article EN cc-by Journal of Pharmaceutical Sciences and Community 2024-11-30
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