A5013086305- Biological Stains and Phytochemicals
- Curcumin's Biomedical Applications
- Cancer-related Molecular Pathways
- Computational Drug Discovery Methods
- Plant-Derived Bioactive Compounds
- Boron Compounds in Chemistry
- Radiopharmaceutical Chemistry and Applications
- Cell death mechanisms and regulation
- Boron and Carbon Nanomaterials Research
- Retinoids in leukemia and cellular processes
- Molecular Biology Techniques and Applications
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Plant Genetic and Mutation Studies
- Alzheimer's disease research and treatments
- Phytoestrogen effects and research
- Bioactive natural compounds
- Synthesis and Characterization of Heterocyclic Compounds
- Cancer, Hypoxia, and Metabolism
- Papaya Research and Applications
- Diverse Scientific Research Studies
- Supramolecular Self-Assembly in Materials
- Ubiquitin and proteasome pathways
- HER2/EGFR in Cancer Research
- Histone Deacetylase Inhibitors Research
Universitas Gadjah Mada
2012-2025
Tokyo Institute of Technology
2021-2022
Yogyakarta State University
2020-2021
COVID-19 pandemic is a serious problem in the world today. The SARS-CoV-2 virus that causes has important proteins used for its infection and development, namely protease spike glycoprotein. RBD (Receptor Binding Domain) of glycoprotein (RBD-S) can bind to ACE2 (Angiotensin Converting Enzyme-2) receptor at domain (PD) (PD-ACE2) host cell, thereby leading viral infection. This study aims reveal potential compounds contained Curcuma sp., Citrus Alpinia galanga, Caesalpinia sappan as anti...
Purpose: Pentagamavunon-1 (PGV-1) is a curcumin analogue that shows cytotoxic activity in various cancer cells. In this study, we evaluated the effect of PGV-1 on highly metastatic breast cell line, 4T1 cells, as an anti-metastatic and anti-proliferative agent. Methods: Cell viability was using MTT assay; while cycle profile, apoptosis incidence, ROS intracellular level were determined by flow cytometry. senescence observed under senescence-associated-β-galactosidase (SA-β-gal) staining...
Ursolic acid, a triterpenoid compound found in various plants, has been garnered significant attention as potential co-chemotherapeutic agent for breast cancer therapy. To comprehensively evaluate the current state of research and identify knowledge gaps, we conducted bibliometric analysis literature pertaining ursolic acid cancer. Using several databases, including Scopus, Google Scholar, PubMed, analyzed publication trends, collaboration patterns, foci within this field from 2000 to 2024....
Purpose: Genistein, a soy isoflavone, exhibits biphasic effect on cells proliferation with some different effects between ER-alpha and ER-beta. The objective of this present study is to determine the modulatory based cell cycle progression under genistein treatment in combination 17-β estradiol (E2) CHO-K1 cells. Methods: 0.1-100 µM was examined by MTT assay. modulation apoptosis were observed using flowcytometry PI PI/AnnexinV staining, respectively. Moreover, E2 senescence cells, ROS level...
Curcumin derivatives B and N were developed as disaggregation agents of amyloid β (Aβ) fibrils. The detoxification provided by each compound at a concentration 1 μM was observed in neuroblastoma cells. Furthermore, both compounds significantly rescued locomotion dysfunction an Aβ-expressing Drosophila model Alzheimer's disease.
Chemoprevention curcumin Analog-1.1 (CCA-1.1) demonstrates antineoplastic effect toward cancer cells. By using triple-negative breast (TNBC), 4T1, and human epidermal growth factor receptor 2 (HER2)-enriched metastatic cells (MCF-7/HER2), we evaluate the cytotoxic antimigration activities from CCA-1.1.The a single treatment of CCA-1.1 in combination with doxorubicin were determined through MTT assay. We also calculated selectivity index data. Migrating evaluated wound healing assay, MMP2...
Effects of methyltestosterone, tamoxifen, genistein and Basella alba extract on masculinization guppy (Poecilia reticulata) Suman Bhusan Chakraborty, Tamás Molnár, Csaba Hancz
The COVID-19 becomes worse with the existence of comorbid diseases such as cardiovascular diseases, metabolic syndromes, inflammation, degenerative well cancer. Therefore, a comprehension approach is needed to combat conditions, not only focusing on virus infection and replication but also directed prevent raising symptoms. This study analyzed potential natural compounds, especially diosmin hesperidin, an anti-SARS-CoV-2 chemopreventive agent against several by using in-silico method....
Purpose: This study aimed to challenge the anticancer potency of pentagamavunone-1 (PGV-1) and obtain a new compound (Chemoprevention-Curcumin Analog 1.1, CCA-1.1) withimproved chemical pharmacological properties.Methods: CCA-1.1 was prepared by changing ketone group PGV-1 into hydroxylgroup with NaBH4 as reducing agent. The product purified under preparative layerchromatography confirmed HPLC show about 93% purity. It tested for itssolubility, stability, cytotoxic activities on several...
Triple-negative breast cancer (TNBC) remains as the deadliest type due to lack of treatment options. Hence, several attempts have been made develop new anticancer for TNBC therapy. This study intended challenge curcumin analog (CCA)-1.1, which is derived from pentagamavunone-1 structure, against 4T1 cell line and model, covering cytotoxic activity in correlation with cycle progression, apoptosis induction, reactive oxygen species (ROS) generation, senescence evidence. The viability, profile,...
Abstract The treatment of glioblastoma multiforme (GBM) is challenging owing to its localization in the brain, limited capacity brain cells repair, resistance conventional therapy, and aggressiveness. Curcumin has anticancer activity against aggressive cancers, such as leukemia, GBM; however, application by low solubility bioavailability. Chemoprevention curcumin analog 1.1 (CCA-1.1), a analog, better stability than those curcumin. In this study, we explored potential targets CCA-1.1 GBM...
Cisplatin is drug of choice toward cervical cancer despite having many side effects, thus researches are conducted in order to find the effective and synergistic co-chemoterapeutic agent combined with cisplatin. In this study, we observed potential cinnamon essential oil (CEO) isolated from Cinnamomum burmannii as cisplatin on HeLa cells covering cytotoxic effect, cell cycle modulation induction apoptosis. Cytotoxic effect was determined by using MTT assay; while apoptosis profile were flow...
Development of chemotherapeutic agent and boron carrying pharmaceutical based on HER2 specific targeted is important due to its role in enhancing cancer progression. The purpose this study synthesize curcumin analogue, namely Pentagamaboron-0 (PGB-0) or 2,5-bis(4-boronic acid)benzylidine cyclopentanone, explore the cytotoxic activity overexpressed-cancer cells. MCF-7/HER2 was used as a model cells NIH3T3 normal PGB-0 bound ATP binding site EGFR molecular docking study. synthesized resulting...
The Analgesic Effect of a Curcumin Analogue 1,5-bis(4’-hydroxy-3’-methoxyphenyl)-1,4-pentadien-3-on (Gamavuton-0) in acute and persistent painZullies Ikawati, Nunung Yuniarti, Supardjan Amir Margono
Objective: To determine the effect of rice bran extract (RBE) in combination with doxorubicin on 4T1 triple-negative breast cancer cells and NIH-3T3 cells. Methods: RBE was obtained by maceration n-hexane. The phytochemical profile observed using highperformance liquid chromatography. Cytotoxic evaluated through MTT assay. In addition, flow cytometry used for cell cycle apoptosis analysis. Cellular senescence SA-β-Gal assay intracellular reactive oxygen species (ROS) levels were DCFDA...
Numerous studies demonstrated CCA-1.1, the modified compound from PGV-1, inhibits tumor cells growth in breast and colorectal cancer. This time, we used bioinformatics molecular interaction approaches to ascertain potential CCA-1.1 activity target focusing on leukemia, along with cytotoxic test leukemia cells. Genomics data expression was collected through COSMIC database by selecting gene sets K562 as a model for chronic myelogenous (CML). We identified PGV-1 predicted targets...
Objective: The present research aims to report cytotoxic and antimigratory activities of the oxidized form brazilin, i.e., brazilein, effects combination brazilein-doxorubicin on MCF-7/HER2 cells. Methods: MTT assay was conducted test activity, while flow cytometry with PI PI-annexin V staining were respectively performed for cell cycle apoptosis analyses. Migration invasion analyses assessed via Boyden chamber assay, HER2, Rac1, p120, MMP2, MMP9 protein levels determined by immunoblotting...
Pumpkin seeds contain lignan phytoestrogens, which have the potential to retrieve menopausal syndromes caused by estrogen deficiency. This study aims determine estrogenic effects of extract pumpkin (EPS). In vitro experiment was performed 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) assay on CHO‐K1 cells. vivo experiments were conducted using 24 7‐weeks‐old female Sprague Dawley rats, divided into four treatment groups (ovariectomized [OVX], ovariectomized for with 2‐μM...