A5038231720- Cancer Cells and Metastasis
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Oral Health Pathology and Treatment
- Cancer-related molecular mechanisms research
- Lung Cancer Research Studies
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Renal cell carcinoma treatment
- Cancer Immunotherapy and Biomarkers
- Wnt/β-catenin signaling in development and cancer
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Cancer Treatment and Pharmacology
- Virus-based gene therapy research
- Colorectal Cancer Treatments and Studies
- Peptidase Inhibition and Analysis
- Cancer, Lipids, and Metabolism
- Renal and related cancers
- Pluripotent Stem Cells Research
- MicroRNA in disease regulation
- Radiopharmaceutical Chemistry and Applications
- Molecular Biology Techniques and Applications
- Cancer-related Molecular Pathways
Universitat de Barcelona
2022
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2022
Universidade da Coruña
2007-2019
Clínica Santa María
2016
Universidad de Navarra
2016
Complexo Hospitalario Universitario A Coruña
2011-2015
Instituto de Investigación Biomédica de A Coruña
2011-2015
Servicio Gallego de Salud
2011-2013
Hospital Universitario 12 De Octubre
2011
Hospital San Juan de la Cruz
2006-2009
Sugars, primarily glucose and fructose, are the main energy source of cells. Because their hydrophilic nature, cells use a number transporter proteins to introduce sugars through plasma membrane. Cancer well known display an enhanced sugar uptake consumption. In fact, transporters deregulated in cancer so they incorporate higher amounts than normal this paper, we compile most significant data available about biochemical biological properties tissues review information carrier expression...
Most of the archived pathological specimens in hospitals are kept as formalin-fixed paraffin-embedded tissues (FFPE) for long-term preservation. Up to now, these samples only used immunohistochemistry a clinical routine it is difficult recover intact protein from FFPE tissues. Here, we report novel, short time-consuming and cost-effective method extract full-length, non-degraded proteins This procedure combined with an effective non-toxic deparaffinisation process extraction based on...
The low probability of curing high-risk prostate cancer (PC) with local therapy suggests the need to study modality therapeutic approaches. To this end, a prospective phase II trial neoadjuvant docetaxel (D) and complete androgen blockade (CAB) was carried out in PC patients. primary end point detect at least 10% pCRs after chemohormonal treatment.Patients T1c-T2 clinical stage prostate-specific antigen (PSA) >20 ng ml(-1) and/or Gleason score >or=7 (4+3) T3 were included. Treatment...
Gene expression is potently regulated through the action of microRNAs (miRNAs). Here, we present evidence a miRNA regulating Hakai protein. was discovered as an E3 ubiquitin-ligase that mediates posttranslational downregulation E-cadherin, major component adherens junctions in epithelial cells and potent tumour suppressor. Recent data have provided affects cell proliferation E-cadherin-independent manner, thus revealing role for early stages progression. Furthermore, highly up-regulated...
Oral and intestinal samples from a cohort of 93 colorectal cancer (CRC) patients 30 healthy controls (non‐CRC) were collected for microbiome analysis. Saliva (28 non‐CRC 94 CRC), feces (30 97 subgingival fluid (20 tumor tissue CRC) used 16S metabarcoding and/or RNA sequencing (RNAseq) approaches. A differential analysis the abundance, performed with ANCOM‐BC package, adjusting P ‐values by Holm‐Bonferroni method, revealed that Parvimonas was significantly over‐represented in CRC ( ‐value...
Vascular endothelial growth factor (VEGF) and its receptor (VEGFR) are overexpressed in the majority of renal cell carcinomas. This characteristic has supported rationale targeting VEGF-driven tumour vascularization, especially clear RCC. VEGF-inhibiting strategies include use tyrosine kinase inhibitors (sunitinib, axitinib, pazopanib, sorafenib) neutralizing antibodies such as bevacizumab. Hypertension (HTN) is one most common adverse effects angiogenesis inhibitors. HTN observed clinical...
In this study, Pelvetia canaliculata L. macroalga, collected from the Atlantic Portuguese coast, was used as a source of bioactive compounds, mostly antioxidants, to incorporate them in sunflower oil with aim increasing its biological value and oxidative stability. The lyophilized alga added oil, ultrasound-assisted extraction (UAE) performed. Algae concentration UAE time varied following central composite rotatable design (CCRD) optimize conditions. parameters were analyzed oils: oxidation...
Bacterial species of the genus Thermoactiomyces are aerobic, Gram-positive, endospore-forming bacteria belonging to order Bacillales. These common in both indoor (as humidifiers) and outdoor (soil pasture) environments, especially agricultural settings. A notable characteristic these is their ability produce endospores containing dipicolinic acid, a component that confers resistance high temperatures desiccation conditions when grown on organic substrates, associated pathophysiological...
Abstract Background The dynamic regulation of cell-cell adhesions is crucial for developmental processes, including tissue formation, differentiation and motility. Adherens junctions are important components the junctional complex between cells necessary maintaining cell homeostasis normal architecture. E-cadherin prototype best-characterized protein member adherens in mammalian epithelial cells. Regarded as a tumour suppressor, loss associated with poor prognosis carcinoma. E3...
Based on the mechanism of action, combining somatostatin analogues (SSAs) with mTOR inhibitors or antiangiogenic agents may provide synergistic effects for treatment patients neuroendocrine tumours (NETs). Herein, we investigate use these combinations in clinical practice. This retrospective cross-sectional analysis NETs treated SSA lanreotide and targeted therapies at 35 Spanish hospitals evaluated efficacy safety The data 159 133 was retrospectively collected. Of patients, a median age...
Two cases of complete remission plus one almost and another partial response undifferentiated, invasive epithelial malignant thymoma using the combination cisplatin, vinblastine, bleomycin (PVB), are reported in four patients treated with this combination. Radiotherapy was instituted after completing fourth course chemotherapy three patients. One patient died from intercurrent infection cycle chemotherapy. Three remain free disease at end treatment program. PVB appears to be highly active...
Vinflunine (VFL) is a microtubule-targeting drug that suppresses microtubule dynamics, showing anti-metastatic properties both in vitro and living cancer cells. An increasing body of evidence underlines the influence microtubules dynamics on cadherin-dependent cell-cell adhesions. E-cadherin marker epithelial-to-mesenchymal transition (EMT) tumour suppressor; its reduced levels carcinoma are associated with poor prognosis. In this report, we investigate role VFL adhesions bladder epithelial...
The relative efficacy and tolerability of the aromatase inhibitors anastrozole (Arimidex) formestane are assessed in a direct comparative trial postmenopausal women with advanced breast cancer. Final results available reported here only for oestradiol suppression. Patients were randomised to receive either oral anastrozole, 1 mg once daily, or formestane, 250 every 2 weeks intramuscularly. In group, mean serum levels fell from 32.1 pmol/l at baseline 6.5 week 1, similar suppression...
e15149 Background: Cabazitaxel is the new chemotherapy standard as second line in castrate resistant prostate cancer (CPRC) [Tropic Trial, Lancet 2010]. The aim of this study was to analyze baseline characteristics and outcomes a different cohort patients (pts) from six hospitals Spain within EAP. Methods: We report 65 pts including EAP trial, who have progressed on or after docetaxel-based chemotherapy. administered dose 25 mg/m2 IV q3wks. All had proven histology confirmation...