A5032561275- Nitric Oxide and Endothelin Effects
- Mitochondrial Function and Pathology
- High-Velocity Impact and Material Behavior
- Energetic Materials and Combustion
- Advanced Graph Theory Research
- Electron Spin Resonance Studies
- Liver Disease and Transplantation
- Complex Network Analysis Techniques
- Topological and Geometric Data Analysis
- Neurological Disease Mechanisms and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Orthopaedic implants and arthroplasty
- Combustion and Detonation Processes
- Biochemical effects in animals
- Renin-Angiotensin System Studies
- Magnesium Alloys: Properties and Applications
- HIV-related health complications and treatments
- Limits and Structures in Graph Theory
- Abdominal Trauma and Injuries
- Liver Disease Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Linguistic Education and Pedagogy
- HIV Research and Treatment
- Education Methods and Technologies
- HIV/AIDS Research and Interventions
Michigan Technological University
2024
Temple University Hospital
2024
Tulane University
2015-2019
U.S. Army Space and Missile Defense Command
2015-2019
University of New Orleans
2018
United States Department of the Army
2015
The Ohio State University
2013-2015
The diverse signaling events following mitochondrial depolarization in neurons are not clear. We examined for the first time effects of on function, intracellular calcium, neuronal nitric oxide synthase (nNOS) activation, and (NO) production cultured perivascular nerves. Cultured rat primary cortical were studied 7-10 days vitro, endothelium-denuded cerebral arteries adult Sprague-Dawley rats ex vivo. Diazoxide BMS-191095 (BMS), activators KATP channels, depolarized mitochondria increased...
Abstract A method for determining the response of a munition to Fragment Impact (FI) stimulus based on hydrocode modeling and statistical analysis is presented. modified version Hugh James Criterion coupled logistic regression technique obtain normalized distance from initiation threshold as determined experimentally through FI tests. The has been shown correlate well with observations at multiple impact velocities various configurations mitigation schemes. total 65 shots have completed date...
A random k -out mapping (digraph) on [ n ] is generated by choosing images of each vertex one at a time, subject to 'preferential attachment' rule: the current selects an image i with probability proportional given parameter α = α( ) plus number times has already been selected. Intuitively, larger becomes, closer resulting uniformly mapping. We prove that Θ( 1/2 threshold for growing 'fast enough' make digraph approach in terms total variation distance. also determine exact limit this...
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This paper will present the results from four series of Fragment Impact (FI) tests on TOW 2B warhead utilizing multiple Particle Mitigation Sleeve (PIMS) configurations. Previously it has been demonstrated that addition a plastic, typically ULTEM® 1000, PIMS reduces sensitivity munition to FI threat. The mechanism by which is reduced reflection shockwave at interface between and case material. munitions this protection scheme applied previously use PBXN-9 as main fill explosive are therefore...
A random k -out mapping (digraph) on [ n ] is generated by choosing images of each vertex one at a time, subject to 'preferential attachment' rule: the current selects an image i with probability proportional given parameter α = α( ) plus number times has already been selected. Intuitively, larger becomes, closer resulting uniformly mapping. We prove that Θ( 1/2 threshold for growing 'fast enough' make digraph approach in terms total variation distance. also determine exact limit this...
Antiretroviral therapies with combinations of mechanistically different classes drugs resulted in reduced HIV‐associated neurocognitive disorders, however, milder forms cognitive disorders continue to be disabling AIDS patients. Toxicity resulting from long‐term use antiretroviral have been implicated the but exact underlying mechanisms are poorly understood. We hypothesized that nelfinavir, a protease inhibitor, causes disruption blood brain barrier (BBB) by promoting mitochondrial...
A random k-out mapping (digraph) on [n] is generated by choosing k images of each vertex one at a time, subject to "preferential attachment" rule: the current selects an image i with probability proportional given parameter \alpha = \alpha(n) plus number times has already been selected. Intuitively, larger gets, closer resulting uniformly mapping. We prove that \Theta(n^{1/2}) threshold for growing "fast enough" make digraph approach in terms total variation distance. also determine exact...
Objective Nitric oxide synthase (NOS) plays an important role in intracellular and intercellular signaling pathways. Experimental studies mitochondria from various tissues, including the brain, have shown possibility of presence a novel mitochondrial variant NOS (mtNOS) located within matrix. We hypothesized that administration inhibitors significantly affects respiration isolated brain mitochondria. Methods Mitochondria were mice aged 8–12 weeks old plated 24‐well microplates for oxygen...
Objective Brain Microvascular endothelial cells (BMECs) form the blood‐brain barrier (BBB) with other cell types such as microglia, astrocytes end feet, pericytes, and a basement membrane. Ischemic stroke damages BBB causing brain injury during reperfusion. in nitric oxide synthase (eNOS) knockout mice showed increased infarct size compared to wild‐type underlying mechanisms are not clear. eNOS produces which plays an important role maintaining vascular homeostasis. Mitochondria play key...
Experimental stroke in animals with gene deletions of endothelial (eNOS) and neuronal (nNOS) nitric oxide synthase isoforms have shown opposite effects on infarct injury. nNOS has been identified recently cells, however, its functional significance is unclear. Our objective was to localize brain microvascular cells (MECs) characterize role. Primary MECs from humans (hMECs) rats (rMECs) were used the studies. Immunohistochemistry von Willebrand factor, eNOS, (total phospho S1417, S847) MECs....
Experimental stroke in animals with gene deletions of endothelial (eNOS) and neuronal (nNOS) nitric oxide synthase isoforms have shown opposite effects on infarct injury. nNOS has been identified recently cells, however, its functional significance is unclear. Our objective was to identify the brain microvascular cells (MECs) characterize role. Primary MECs from humans (hMECs), rats (rMECs), mice (mMECs) along cultured primary rat cortical neurons were used studies. In addition, microvessels...
Objective: Mice with genetic deletion of endothelial (eNOS; protective) and neuronal (nNOS; detrimental) nitric oxide synthase isoforms exhibit dramatically opposite consequences ischemic brain injury. nNOS has been identified recently in cells, however, its functional significance is unclear. Our objective was to identify characterize role primary microvascular cells (MECs). Methods Results: MECs from humans (hMECs), rats (rMECs), mice (mMECs) along cultured rat cortical neurons were used....
Deletions of endothelial (eNOS) and neuronal (nNOS) nitric oxide synthase isoforms in mice have been shown to elicit opposite effects on ischemic brain injury following experimental stroke. Recently, we demonstrated the expression nNOS human, rat, mouse primary microvascular cells (MECs). The constitutively active (enNOS) was found be functionally distinct from expressed neurons eNOS but sensitive inhibition by pharmacological inhibitors. Under physiological conditions, enNOS produce...
Objective Ischemic brain injury has been shown to be increased in endothelial nitric oxide synthase (eNOS) knockout mice but reduced neuronal (nNOS) compared the wild‐type mice. It proposed that NO derived from nNOS neurons is detrimental whereas eNOS cells protective after stroke. However, functional mechanism underlying this protection or damage never studied. Mitochondria play an important role a wide range of physiological and pathophysiological processes. Besides generation cellular...