A5083187279- Bone Metabolism and Diseases
- Bone health and treatments
- Central Venous Catheters and Hemodialysis
- Neutropenia and Cancer Infections
- Nuclear Physics and Applications
- Nuclear reactor physics and engineering
- Mitochondrial Function and Pathology
- Venous Thromboembolism Diagnosis and Management
- Palliative Care and End-of-Life Issues
- Cancer, Stress, Anesthesia, and Immune Response
- Cardiac Ischemia and Reperfusion
- Medicinal plant effects and applications
- Musculoskeletal synovial abnormalities and treatments
- Cytokine Signaling Pathways and Interactions
- Diagnosis and Treatment of Venous Diseases
- Religion, Spirituality, and Psychology
- Cancer-related gene regulation
- Clinical practice guidelines implementation
- Biological Activity of Diterpenoids and Biflavonoids
- Grief, Bereavement, and Mental Health
- Estrogen and related hormone effects
- Clostridium difficile and Clostridium perfringens research
- NF-κB Signaling Pathways
- Vascular Procedures and Complications
- Wnt/β-catenin signaling in development and cancer
Sichuan University
2010-2025
Shanghai First People's Hospital
2021-2025
Xi'an Jiaotong University
2023
Shanghai Jiao Tong University
2020-2023
State Key Laboratory of Oncogene and Related Genes
2021
Renji Hospital
2020-2021
West China Hospital of Sichuan University
2019-2021
East China Normal University
2015-2021
Shanghai Clinical Research Center
2021
State Key Laboratory of Biotherapy
2020
Abstract Human hexokinase 2 is an essential regulator of glycolysis that couples metabolic and proliferative activities in cancer cells. The binding to the outer membrane mitochondria critical for its oncogenic activity. However, regulation remains unclear. Here, we report SUMOylation regulates mitochondria. We find can be SUMOylated at K315 K492. SUMO-specific protease SENP1 mediates de-SUMOylation 2. SUMO-defective preferably binds enhances both glucose consumption lactate production...
Acute kidney injury (AKI) is a critical clinical condition that causes fibrosis, and it currently lacks specific treatment options. In this research, we investigate the role of SENP1-Sirt3 signaling pathway its correlation with mitochondrial dysfunction in proximal tubular epithelial cells (PTECs) using folic acid (FA) ischemia-reperfusion-induced (IRI) AKI models. Our findings reveal Sirt3 SUMOylation site mutation (Sirt3 KR) or pharmacological stimulation (metformin) protected mice against...
The fourth member of the leucine-rich repeat-containing GPCR family (LGR4, frequently referred to as GPR48) and its cognate ligands, R-spondins (RSPOs) play crucial roles in development multiple organs well survival adult stem cells by activation canonical Wnt signaling. Wnt/β-catenin signaling acts regulate breast cancer; however, molecular mechanisms determining spatiotemporal regulation are largely unknown. In this study, we identified LGR4 a master controller signaling-mediated cancer...
Therapeutics targeting osteoclasts are commonly used treatments for bone metastasis; however, whether and how regulate premetastatic niche tropism largely unknown. In this study, we report that osteoclast precursors (OPs) can function as a component facilitates breast cancer (BCa) metastasis at early stages. At the molecular level, unbiased GPCR ligand/agonist screening in BCa cells suggested R-spondin 2 (RSPO2) RANKL, through interaction with their receptor LGR4, promoted osteoclastic...
N6-methyladenosine (m6A) of mRNAs modulated by the METTL3-METTL14-WTAP-RBM15 methyltransferase complex and m6A demethylases such as FTO play important roles in regulating mRNA stability, splicing, translation. Here, we demonstrate that FTO-IT1 long noncoding RNA (lncRNA) was upregulated positively correlated with poor survival patients wild-type p53-expressing prostate cancer (PCa). RIP-seq analysis revealed knockout increased methylation a subset p53 transcriptional target genes (e.g., FAS,...
The HOX genes are a group of highly conserved Homeobox-containing that control the body plan organization during development. However, their contributions to tumorigenesis and tumor progression remain uncertain controversial. Here we provided evidence tumor-suppressive activity HOXD13 in prostate cancer. depletion contributes more aggressiveness cancer cells vitro vivo. These effects were corroborated metastatic mice model, where observed bone lesions formed by with ablation....
Abstract Excessive RANKL signaling leads to superfluous osteoclast formation and bone resorption, is widespread in the pathologic loss destruction. Therefore, targeting or its pathway has been a promising successful strategy for this osteoclast-related diseases. In study, we examined effects of xanthohumol (XN), an abundant prenylflavonoid from hops plant, on osteoclastogenesis, resorption RANKL-induced using both vitro vivo assay systems. mouse human, XN inhibited differentiation at early...
Adhesion GPCR Gpr126/Adgrg6 regulates mouse body length and bone mass by controlling osteoblast differentiation.
Abstract Background Chemotherapy is an important approach for lung cancer patients. The study was designed to evaluate the feasibility of compound probiotic supplements in improving quality life patients undergoing chemotherapy. Methods This randomized, double‐blind, placebo‐controlled trial enrolled chemotherapy‐naive with who were scheduled receive platinum‐based doublet All eligible randomly administered (1:1) (group BP‐1) or placebo C) two chemotherapy cycles. EORTC QLQ C30 questionnaire...
Abstract Reproductive hormones associated with the hypothalamic-pituitary-gonadal (HPG) axis are closely linked to bone homeostasis. In this study, we demonstrate that Gonadotropin inhibitory hormone (GnIH, one of key reproductive upstream HPG axis) plays an indispensable role in regulating homeostasis and maintaining mass. We find deficiency GnIH or its receptor Gpr147 leads a significant reduction mineral density (BMD) mice primarily by enhancement osteoclast activation vivo vitro....
Background The authority to prescribe drugs has been reserved only for the medical community, mainly clinicians. Recently, more and countries worldwide have begun implementing reforms grant advanced practice nurses (APNs) from legislative level. This study aimed explore prescription forms gastrointestinal dermatological symptom management of cancer patients that APNs can in China. Design A qualitative reported accordance with Conducting REporting DElphi Studies guidelines. modified Delphi...
Giant cell tumor of bone (GCTB) is a rare and highly osteolytic that usually leads to an extensive lesion. The purpose this study was discover novel therapeutic targets identify potential agents for treating GCTB. After screening the serum cytokine profiles in 52 GCTB patients 10 normal individuals using ELISA assay, we found NF-κB signaling-related cytokines, including TNFα, MCP-1, IL1α, IL17A, were significantly increased patients. results confirmed by IHC expression activity p65 Moreover,...
Background: The Tibetan population is minority in southwest China, and data on the psychological states of cancer inpatients are not available. study participants included Han inpatients, their depression anxiety were investigated analyzed to understand patients. aim present was incidence among factors affecting anxiety. Methods: We used questionnaires investigate inpatients. Zung Self-Rating Anxiety Scale, Depression a general information questionnaire. Results: results showed that there 61...
Abstract Background: To investigate the attitudes and preferences toward fecal microbiota transplantation (FMT) among patients with cancer, during anti-tumor treatment in hospital. Methods: A self-report questionnaire was administered to survey 101 cancer at Cancer Center of West China Hospital their hospitalization treatment. The were asked about willingness undergo FMT, regarding donor, route, expenditure, possible adverse effects. Results: Most willing accept FMT. Patients younger adults...