A5005639453- Lipoproteins and Cardiovascular Health
- Genetic Associations and Epidemiology
- RNA modifications and cancer
- Cardiovascular Disease and Adiposity
- Nuclear Receptors and Signaling
- Cardiomyopathy and Myosin Studies
- Cardiac Imaging and Diagnostics
- Cardiovascular Health and Risk Factors
- Cardiac Fibrosis and Remodeling
- RNA Research and Splicing
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Congenital heart defects research
- Healthcare Regulation
- Mobile and Web Applications
- Health Promotion and Cardiovascular Prevention
- BRCA gene mutations in cancer
- Cardiac Structural Anomalies and Repair
- Maternal and Neonatal Healthcare
- Chronic Disease Management Strategies
- Protein Kinase Regulation and GTPase Signaling
- Healthcare Operations and Scheduling Optimization
- Nutritional Studies and Diet
- Software System Performance and Reliability
- Protein Tyrosine Phosphatases
Hospital Dr. Nélio Mendonça
2022-2024
University of Minho
2024
Introdução: O acidente vascular cerebral (AVC) é uma condição clínica grave que ocorre devido à obstrução (AVC isquêmico) ou ruptura hemorrágico) de vasos sanguíneos no cérebro, podendo causar déficits neurológicos graves e até morte. AVC isquêmico, representa 80% dos casos, tratado com trombolíticos, como a alteplase. No entanto, tenecteplase, variante geneticamente modificada da alteplase, tem sido estudada alternativa por apresentar vantagens maior especificidade fibrina, meia-vida mais...
Low-code is an approach to programming that seeks enable the creation of artefacts by both programmers and non-programmers. It enables rapid delivery applications with minimal effort write in a language as well for installation configuration environments, training deployment. This allows development follow needs company faster more efficient way. Thus, web platform was created user customize dashboard composed mainly graphs widgets, order make most data. However, beyond this specific...
Alcohol-induced cerebellar ataxia ACA is a common acquired characterized by degeneration resulting from long-term exposure to alcohol. However the role of physiotherapy in treatment unclear. The aim this study was evaluate effect on balance and coordination an individual with alcohol-induced ataxia. A 35-year-old male diagnosed underwent program involving gait training exercises in-hospital environment for two weeks twice daily 35-40 minutes. outcome measures used were Berg Balance Scale BBS...
Abstract Background The most effective approach to prevent coronary artery disease (CAD) in the general population remains quantify individual risk of CAD followed by controlling factors. There has been a lot curiosity investigate several scores individually for improving prediction. However, whether one would be better than other same is still unclear. Aim To evaluate performance three scores, European SCORE2, Coronary calcium score (CACS) and Genetic (GRS), predicting discriminating...
Abstract Background The Hepatocyte nuclear factor 4 A (HNF4A) gene was considered to be associated with susceptibility atherosclerosis and coronary artery disease (CAD). It encodes a protein HNF4α, genetic transcription regulating the expression of thousands genes playing essential roles in glucose lipid metabolism. Its abnormal is emerging as critical diabetes, dyslipidemia, cancer. Loss function specific mutations could attenuate its role CAD pathogenesis progression atherosclerosis. Aim...
Abstract Coronary Artery Disease (CAD) is a lethal illness that kills millions of individuals each year worldwide. This disorder multifactorial, resulting in the complex interplay genetic, epigenetic, and environmental factors. Exploring gene-gene gene-environment interactions essential to understanding aetiology common diseases like CAD. Aim We proposed investigating interaction between two genetic variants robustly associated with CAD by GWAS (MTHFR rs1801133 APOE rs7412/rs429358)...
Abstract Introduction Aortic valve calcium (AVC) deposition is one of the mechanisms behind aortic sclerosis and stenosis. There a known association between LPA gene rs3798220 T>C polymorphism development severe However, it still unknown if has been driving factor since early stages disease. Objective Investigate, in our population, variant calcification. Methods AVC was measured 451 consecutive individuals from prospective arm GENEMACOR study with mean age 63.4±9.7 years, 58.8% male....
Abstract Background It is known that a low HDL-c level associated with high risk of overall mortality. Consequently, it was presumed achieving higher levels high-density lipoprotein cholesterol (HDL-c) would reduce the or even extend lifespan. However, clinical trials medical intervention failed to find benefits. Aim We aimed investigate association between and mortality using prospective cohort from Portugal. Methods A sub-study (2001-2022) performed in 1718 participants without coronary...
Abstract Coronary Artery Disease (CAD) shares environmental and genetic factors. Young patients with acute coronary syndrome (ACS) carry a poor long-term prognosis. The clinical utility of information in predicting CAD events remains unknown. Aim Evaluate the multiplicative Genetic Risk Score (mGRS) to predict lifelong residual risk below 55 years few Methods 475 non-diabetic LDL cholesterol levels 100mg/dL at first admission who suffered prior MI age ≤55 were followed prospectively for mean...
Abstract Introduction Lp(a) and type 2 diabetes mellitus are both known established risk factors for the development of coronary artery disease (CAD). levels 75% to 95% heritable predominately determined by single-nucleotide variants at LPA gene; rs3798220 is one most studied accounts a significant portion levels. Whether could influence account unknown. Aim Evaluate whether there different association between polymorphism T>C their with CAD in diabetic non-diabetic populations....
Abstract Background The functional dissection of genetic risk opens the door to strategies for pharmacological manipulation molecular and cellular processes implicated in human diseases, including coronary artery disease (CAD). Aim To assess relationship between a set single nucleotide polymorphisms previously associated with CAD calcium (CAC) score an asymptomatic population from Portugal. Methods Prospective study cohort 1,284 subjects aged 59.3±8.9 years, 73.6% males without apparent CAD....
Abstract Introduction High lipoprotein(a) [Lp(a)] concentrations are one of the most important genetically determined risk factors for coronary artery disease (CAD). Many functional single nucleotide polymorphisms (SNPs) LPA gene have pronounced effects on Lp(a) concentrations. Studies show that rs3798220 polymorphism is strongly associated with concentration and also CAD. Goal: To evaluate if T>C CAD beyond its effect levels. Methods We performed a case-control study 3,157...
Abstract The GJA4 gene encodes a protein called connexin 37, component of gap junctions in vascular endothelial cells, crucial regulating function and influencing inflammation, platelet adhesion thrombus formation. This deletion mice diminished formation vitro human blood. In these circumstances, inhibition with pharmacological agents may represent potential avenues for developing novel antithrombotic agents. Aim To investigate whether the rs618675 T>C variant is risk factor...
Background and objective: Alcohol consumption causes alterations in the neural circuits which can cause severe physical dysfunctions. Furthermore, during natural aging process, several functional are observed. Use Disorder (AUD) is a chronic progressive disease influenced by genetic, psychosocial environmental factors. Thus, considering consequence of alcohol ageing this study aimed to find degree motor impairment along with quality life older adults consumption. Method: A comparative was...
Abstract Background Cardiovascular disease (CVD) remains the leading cause of death worldwide. One its main contributors is coronary artery (CAD), a complex multifactorial influenced by hereditary and environmental factors. A better cardiovascular risk assessment real challenge in our daily clinical practice. Evidence points to high Epicardial Adipose Tissue (EAT) volume as an essential player pathophysiology CAD. On other hand, genetic predisposition CAD crucial improve treatment. It...
Abstract Introduction Coronary artery disease (CAD) is a dynamic inflammatory caused by atherosclerosis. GWAS showed that ZNF259 rs964184 encoding zinc finger protein (ZPR1) was associated with dyslipidemia and CAD. Recent research found ZPR1 transcription up-regulated in the brain of mice fed high-fat diet, influencing cell cycle, apoptosis, RNA metabolism neurons. This process at heart vessels may increase oxidative stress Purpose Study association between C>G polymorphism CAD...
Abstract Introduction Lipoprotein(a) [Lp(a)] is an LDL-like molecule composed of a part apolipoprotein(a) bounding covalently to apolipoprotein B-100. High plasma Lp(a) levels were associated with MACE in stable CAD patients. Recent research shows contradictory results patients high plasmatic and impaired glucose metabolism occurrence. Purpose Investigate whether metabolism, at extended follow-up. Methods A prospective cohort 1,127 (pre-diabetes diabetes) was observed during 4.9±3.4 years....
Abstract Previous research associates the PSRC1 gene on chromosomal locus 1p13.3 with coronary artery disease (CAD). Specifically, A wild allele of rs599539 A>G was identified as a risk for CAD, and mutated G minor reduced CAD. However, underlying genetic mechanism is not yet fully understood controversial in other populations. Aim To investigate association rs599839 variant CAD lipid profile Portuguese population from Madeira Island. Materials Methods We performed case-control study...