A5030192864- Nutrition, Genetics, and Disease
- Genetic Associations and Epidemiology
- Cardiovascular Function and Risk Factors
- Lipoproteins and Cardiovascular Health
- Cardiovascular Disease and Adiposity
- Cardiovascular Health and Risk Factors
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Heart Failure Treatment and Management
- Nuclear Receptors and Signaling
- RNA modifications and cancer
- Hormonal Regulation and Hypertension
- Folate and B Vitamins Research
- Cardiac Valve Diseases and Treatments
- BRCA gene mutations in cancer
- Birth, Development, and Health
- Blood Pressure and Hypertension Studies
- Cardiomyopathy and Myosin Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Diabetes Treatment and Management
- Congenital heart defects research
- Nutritional Studies and Diet
- Paraoxonase enzyme and polymorphisms
- Congenital Heart Disease Studies
Hospital Dr. Nélio Mendonça
2016-2025
Universidad José Vasconcelos
2025
Faculdade de Medicina do ABC
2019-2023
University of Lisbon
2020
Universidade Nova de Lisboa
2020
Instituto de Historia
2014-2015
Hospital Pró-Cardíaco
2006
Abstract Aims Coronary artery calcium score (CACS) and polygenic risk have been used as novel markers to predict cardiovascular (CV) events of asymptomatic individuals compared with traditional scores. No previous studies directly the additive capacity these two relative conventional The aim study was evaluate change in CV prediction ability when CACS, genetic (GRS), or both are added Systematic Risk Evaluation 2 (SCORE2). Methods results In a prospective, observational population-based...
Abstract Introduction Cardiovascular surgery with cardiopulmonary bypass (CPB) has improved in past decades, but inflammatory activation this setting is still unpredictable and associated several postoperative complications. Perioperative levels of macrophage migration inhibitory factor (MIF) other mediators could be implicated adverse outcomes cardiac surgery. Methods Serum MIF, monocyte chemoattractant protein (MCP)-1, soluble CD40 ligand, IL-6 IL-10 from 93 patients subjected to CPB were...
Abstract Background Several polymorphisms within the renin-angiotensin system cluster of genes have been associated with advent coronary artery disease (CAD) or related pathologies. We investigated distribution 5 these in order to find any association CAD development and distinguish if biochemical behavioural factors interact genetic disease. Methods ACE I/D (rs4340), A11860G (rs4343), AT1R A1166C (rs5186), AGT T174M (rs4762) M235T (rs699) gene were PCR-RFLP analysed 298 patients 510...
Subjects without cardiovascular (CV) disease (CVD) may suffer from subclinical atherosclerosis, and are at increased risk for atherosclerotic CV events (ASCVE). The ESC/EAS SCORE was updated by SCORE2, which estimates 10-year of fatal non-fatal CVD in European populations aged 40-69 years established or diabetes. Our aim to compare the two scores validate SCORE2 our population.
Introdução: As Doenças Crônicas Não-Transmissíveis como, por exemplo, Diabetes Mellitus. A DM é uma doença caracterizada pelo comprometimento do metabolismo da glicose, resultando em hiperglicemia crônica. Divide-se Tipo 1, 2, gestacional e outros tipos específicos. O mundo enfrenta atualmente epidemia de casos DM, com destaque para a DM2. Todavia, apesar dos avanços no tratamento, continua sendo quinta principal causa morte mundo. Objetivo: artigo objetiva trazer análise epidemiológica,...
INTRODUÇÃO: O diabetes mellitus tipo 2 (DM2) representa uma condição crônica e progressiva que afeta proporção crescente da população mundial. Sua prevalência tem aumentado substancialmente, impulsionada por fatores como o envelhecimento população, a urbanização, dieta inadequada sedentarismo, levando carga para os sistemas de saúde. A relação entre obesidade DM2 é bem documentada, vez amplifica suscetibilidade genética ambientais, contribuindo resistência à insulina, característica central...
Este artigo tem por objetivo realizar uma revisão sistemática e meta-análise para comparar a eficácia segurança do ácido bempedoico às estatinas no tratamento da dislipidemia. A metodologia seguiu as diretrizes PRISMA, utilizando bases PubMed, Embase, Cochrane Library Scopus, com os termos “bempedoic acid”, “statins”, “cardiovascular events”, “mortality” “adverse events”. Foram incluídos ensaios clínicos randomizados até 1º de janeiro 2025. Os resultados evidenciaram que o não apresentou...
Decoding the genetic basis of coronary artery disease (CAD) through an intermediate phenotype - calcification can help us to better understand this deadly and enable creation therapeutic strategies. This work aims assess relationship between a set single nucleotide polymorphisms (SNPs) previously associated with CAD calcium (CAC) score in Portuguese asymptomatic population. A prospective study was conducted cohort 1284 subjects (aged 59.3±8.9 years, 73.6% males) without CAD. CAC performed...
Abstract Introduction Current research showed that the triglyceride glucose (TyG) index is a cheap clinical marker associated with coronary artery calcium (CAC) score and atherosclerotic cardiovascular disease (ASCVD). Nevertheless, its relationship occurrence of early ASCVD events remains uncertain. Objective We intend to evaluate association between TyG CAC score, subclinical atherosclerosis, in normal population free apparent Cardiovascular (CVD). After that, we investigated whether this...
Abstract Introduction Coronary artery calcium score (CAC) has been recognized as a severity marker in evaluating subclinical atherosclerosis and increased cardiovascular risk. Aortic valve calcification (AVC) associated with aortic sclerosis stenosis for many years. Recent evidence shown that it can also be helpful risk assessment. The role of traditional factors on the atherosclerotic process is well established, but their impact disease distribution still relatively unknown. Objective...
Introdução: A hipertensão arterial é uma doença complexa, multifatorial, controlada por fatores genéticos e ambientais.Objetivo: Avaliar a susceptibilidade genética no aparecimento de sua associação com os risco tradicionais na eclosão desta patologia.Material Métodos: Estudo caso-controlo 1712 indivíduos, idade média 51,0 ± 7,9 anos (860 hipertensos 852 controlos). Avaliaram-se tradicionais, bioquímicos as variantes genéticas: ACE I/D rs4340, A2350G rs4343, AGT T174M rs4762, M235T rs699...
<b><i>Background/Aims:</i></b> Cardiovascular diseases are the major cause of morbidity and mortality in hemodialysis (HD) patients. These patients present reduced paraoxonase 1 (PON1) activity that depends on genetic non-genetic factors; however, how these factors influence PON1 HD is poorly clarified. Our aim was to evaluate two polymorphisms <b><i>Methods:</i></b> We evaluated 183 under recombinant human erythropoietin (rhEPO) treatment 22...
Recent genetic studies have revealed an association between polymorphisms at the ADAMTS7 gene locus and coronary artery disease (CAD) risk. Functional shown that a CAD-associated polymorphism (rs3825807) affects maturation vascular smooth muscular cell (VSMC) migration. Here, we tested whether (A/G) SNP is associated with cardiovascular (CV) survival in patients established CAD. A cohort of 1,128 angiographic proven CAD, who were followed up prospectively for mean follow-up period 63 (range...
Evidence points epicardial adipose tissue (EAT) as an emerging cardiovascular risk marker. Whether genetic polymorphisms linked with atherosclerosis are associated higher EAT is still unknown. We aim to assess the role of burden and its association in a cohort asymptomatic individuals without coronary disease. A total 996 participants were prospectively enrolled single Portuguese center. volume was measured by Cardiac Computed Tomography distributed into 2 groups, above below median EAT....
Several genetic risk scores (GRS) have been associated with cardiovascular disease; their role, however, in survival from proven coronary artery disease (CAD) yielded conflicting results.The objective of this study was to evaluate long-term mortality according the score a Southern European population CAD.A cohort 1464 CAD patients angiographic were followed up prospectively for 58.3 (interquartile range: 25.8-88.1) months. Genotyping 32 single-nucleotide polymorphisms previously performed...
Background: Genetic risk score can quantify individual’s predisposition to coronary artery disease; however, its usefulness as an independent predictor remains inconclusive. Objective: To evaluate the incremental predictive value of a genetic traditional factors associated with disease. Methods: Thirty-three variants previously disease were analyzed in case-control population 2,888 individuals. A multiplicative was calculated and then divided into quartiles, 1st quartile reference class....
The utility of genetic risk scores (GRS) as independent predictors remains inconclusive. Here, we evaluate the additive value a multi-locus GRS to Framingham score (FRS) in coronary artery disease (CAD) prediction. A total 2888 individuals (1566 patients and 1322 controls) were divided into three subgroups according FRS. Multiplicative was determined for 32 variants associated CAD. Logistic Regression Area Under Curve (AUC) first, using TRF each FRS subgroup, secondly, adding GRS. Different...
Coronary artery disease (CAD), characterized by an atherogenic process in the coronary arteries, is one of leading causes death Madeira. The GENEMACOR (GENEs MAdeira and CORonary Disease) study sought to investigate main risk factors - environmental genetic estimate whether a score (GRS) improves CAD prediction, discrimination reclassification.Traditional 33 variants were considered case-control with 3139 individuals (1723 patients 1416 controls). multivariate analysis assessed likelihood...
Essential hypertension (EH) is a complex disease in which physiological, environmental, and genetic factors are involved its genesis. The variant of the alpha-adducin gene (ADD1) has been described as risk factor for EH, but with controversial results. objective this study was to evaluate association ADD1 (Gly460Trp) polymorphism EH population from Madeira Island. A case-control 1614 individuals Caucasian origin performed, including 817 797 controls. Cases controls were matched sex age, by...