A5115494969- DNA and Nucleic Acid Chemistry
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- RNA and protein synthesis mechanisms
- Mesoporous Materials and Catalysis
- Viral Infections and Immunology Research
- Carbon and Quantum Dots Applications
- Silicon Nanostructures and Photoluminescence
University of Naples Federico II
2024-2025
ABSTRACT The natural compound orotic acid and its anionic form, orotate, play a pivotal role in various biological processes, serving as essential intermediates pyrimidine de novo synthesis, with demonstrated connections to dietary, supplement, neurodrug applications. A novel perspective on biomolecular aggregation at the nanoscale, particularly pertinent neurodegeneration, challenges established paradigm positing that peptide (amyloid beta) protein (tau) mainly govern molecular events...
This study investigates, for the first time, ability of calixarene ligands to interact with G-quadruplex (GQ) DNA assemblies, which play a critical role in many biological processes, including gene expression regulation, telomere maintenance, and surveillance genome stability repair mechanisms. Specifically, interaction between two calix[4]arene compounds, featuring cationic or zwitterionic functional groups on their upper rim, parallel tetramolecular (TG4T)4 used as model, was analyzed...
The ON 1, bearing the lipophilic TBDPS groups at both 5′ ends, produces − after annealing procedure in K + -containing buffer highly G-quadruplex 2, which spontaneously assembles into ordered G4 aggregates.
Porous silicon is one of the most explored nanostructured materials in various biomedical applications owing to its remarkable properties. However, inherent chemical instability mandates a robust surface modification procedure, and proper bioengineering essential ensure effectiveness field. In this study, we introduce one-pot functionalization strategy that simultaneously stabilizes porous nanoparticles decorates their with carbohydrates through hydrosilylation chemistry, combining mild...