A5103943531- Pancreatic and Hepatic Oncology Research
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Gallbladder and Bile Duct Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatitis Pathology and Treatment
- Clinical Nutrition and Gastroenterology
- Renal Transplantation Outcomes and Treatments
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Transplantation: Methods and Outcomes
- Neuroendocrine Tumor Research Advances
- Pediatric Hepatobiliary Diseases and Treatments
- Organ and Tissue Transplantation Research
- Urological Disorders and Treatments
- Liver physiology and pathology
- Pharmacological Effects and Toxicity Studies
- Renal cell carcinoma treatment
- Esophageal and GI Pathology
- Diet and metabolism studies
- Congenital Anomalies and Fetal Surgery
- Gastrointestinal Tumor Research and Treatment
- Hematopoietic Stem Cell Transplantation
- Biliary and Gastrointestinal Fistulas
- Gastrointestinal disorders and treatments
Georgetown University
2012-2024
Georgetown University Medical Center
2023-2024
MedStar Georgetown University Hospital
2019-2023
MedStar Heart & Vascular Institute
2020-2023
Pontificia Universidad Católica de Chile
2009-2020
Production Development Corporation
2019
Colciencias
2019
Hospital Médica Sur
2018
Universidade Estadual de Campinas (UNICAMP)
2018
Lenox Hill Hospital
2008
The Balance of Risk (BAR) Score, a simple scoring system that combines six independent donor and recipient variables to predict outcome after liver transplantation (LT), was validated in large U.S./European cohort patients. This study aims assess the performance BAR score survival determine factors associated with short long-term Latin-American A retrospective performed 194 patients [112 (55.4%) males; mean age 52 ± 14 years] who underwent 202 LT during period 2003–2015. Demographic,...
Colonoscopy is a safe and routinely performed diagnostic therapeutic procedure for different colorectal diseases.Although the most common complications are bleeding perforation, extracolonic or visceral injuries have also been described.Splenic rupture rare complication following colonoscopy, with few cases reported.We report 60-year-old female who presented to surgical consultation 8 h after colonoscopy.Clinical, laboratory imaging findings were suggestive massive hemoperitoneum.At surgery,...
Graft versus host disease (GVHD) is an uncommon but highly morbid complication of intestinal transplantation (ITx). In this study, we reviewed our 17-y experience with GVHD focusing on factors predicting occurrence and survival.Retrospective review 271 patients who received 1 or more ITx since program inception in 2003 survival analysis using Cox proportional hazard modeling.Of patients, 28 developed GHVD 34 (18-66) d after presenting rash fever 26, rectosigmoid 1, hemolysis 1; other sites,...
Biliary strictures after liver transplantation are common and when refractive to endoscopic percutaneous intervention require surgical revision. Robotic technology facilitates minimally invasive biliary reconstruction has not previously been described transplantation. revisions were retrospectively compared all the historical open cases over a time period from May 2013 October 2020. During study there 3 robotic 4 with follow-up of at least 6months. All hepaticojejunostomies for late...
Objectives Amylase level in drains (ALD) has been proposed as a predictor for the development of clinically significant pancreatic fistula (CS-PF) patients undergoing major surgery. This study aimed to determine if ALD who developed CS-PF after pancreatoduodenectomy is higher than that with transient fistulae and establish threshold value CS-PF. Methods From January 2002 December 2012, all were enrolled. At least 1 measurement on postoperative day 3 was obtained. Pancreatic (PF) defined...
Summary Background Per‐oral tacrolimus administration is not always practicable. Sublingual a potential alternative, but its feasibility and effectiveness compared with oral route has been established. Aim To compare drug exposure after sublingual in liver transplant recipients. Methods Experimental, open‐label, non‐randomised, cross‐over study. Tacrolimus was evaluated 32 recipients receiving administration. 12 h area‐under‐the‐curve ( AUC 0–12 ) calculated using blood concentrations at...
<b><i>Background/Aims:</i></b> One hallmark of chronic liver disease in patients with portal hypertension is the formation portal-systemic collaterals which angiogenesis has a fundamental role. We studied undergoing transplantation to correlate levels circulating angiogenic factors and peripheral circulation pressure collaterals. <b><i>Methods:</i></b> Sixteen who underwent were enrolled. During transplant surgery, we determined venous...
Abstract Background N ucleotide oligomerization domain 2 ( NOD ) has been associated with intestinal immunity after the discovery that its polymorphisms are linked to C rohn's disease CD ). Intestinal failure IF represents a wider spectrum of diseases where homeostasis disrupted. Aim To evaluate prevalence mutations in population as well association different conditions causing this problem. Methods One hundred ninety‐two consecutive patients and 103 healthy controls were genotyped for three...
Purpose: Undertake a comparison between laparoscopic distal pancreatectomy (LDP) and open (ODP) for the management of benign malignant lesions. Methods: A case series study 93 consecutive patients subjected to pancreatic tumors 2001 2015. In each patient, clinical surgical characteristic, postoperative course, histopathologic examination, survival were analyzed. Results: LDP was associated with significantly less operative blood loss (50 mL vs. 300 mL; P <0.01), higher spleen preservation...
Liver biopsy is a common procedure usually required for final pathologic diagnosis of different liver diseases. Morbidity following tru-cut uncommon, with bleeding complications generally self-limited. Few cases major hemorrhage after biopsies have been reported, but to our knowledge, no emergency hepatectomy reported previously.We report the case 38 years-old woman who presented an intrahepatic arterial under direct laparoscopic visualization, initially controlled by ligation right hepatic...
Benítez, Carlos M.D.; Inzunza, Martin Riveros, Sergio Rivas, Violeta Garrido, Marcelo Dib, Barrera, Francisco Arab, Juan P. Torres, Javiera Cortinez, Luis I. Briceño, Eduardo Guerra, F. Fernandes, Martínez, Jorge A. M.D. Author Information
We analyzed the fecal microbiome by deep sequencing of 16S ribosomal genes and metabolomic profiles 43 intestinal transplant recipients to identify biomarkers graft function. Stool samples were collected from 23 patients with stable function five years or longer after transplant, 15 one-year post-transplant four refractory rejection loss within post-transplant. Lactobacillus Streptococcus species predominant in both short long term, a profile consistent general population. Conversely,...
Gastrointestinal neuroendocrine tumors (NET) frequently present with unresectable hepatic metastases, which poses a barrier for curative treatment. Resection of the primary tumor and subsequent orthotopic liver transplantation (OLT) has been proposed as treatment approach but available data in this regard is limited. We clinical case an otherwise asymptomatic 44-yo man complaining abdominal pain dyspepsia that was diagnosed 10 cm duodenal multiple metastases. A CT-guided biopsy confirmed...
Surgical resection is the only treatment associated with long-term cure in patients liver metastasis from colorectal cancer, achieving a 30% to 40% five years survival.To evaluate results of for metastatic cancer our centre.Retrospective study. Epidemiological, perioperative and follow up data undergoing between January 1990 July 2007 were assessed. We compared two periods; period 1 (1990-1997) 2 (1998-2007).Sixty six aged 61+/- 12 (46 males) underwent 75 resections. An anatomical excision...
In patients suffering intestinal failure due to short bowel, the goal of an Intestinal Rehabilitation Program is optimize and tailor all aspects clinical management, eventually, wean off lifelong parenteral nutrition.To report results our program in failure.A registry referred Failure unit between January 2009 December 2015 was constructed. Initial work up included prior surgery, blood tests, endoscopic imaging studies. Also demographic data, medical surgical management as well follow-up,...
PurposeDespite improvement in systemic therapy, patients with pancreatic ductal adenocarcinoma (PDAC) frequently experience local recurrence. We sought to determine the safety of hypofractionated proton beam radiotherapy (PBT) during adjuvant chemotherapy.Methods and PatientsNine were enrolled a single-institution phase I trial (NCTXXXXXXXX) between 2019 2022. Patients had PDAC head underwent R0 or R1 resection modified FOLFIRINOX (mFFX) chemotherapy. The primary endpoint was dosing schedule...
There are many reports concerning the surgical treatment of patients with Barrett's esophagus, but very few focus on histological changes inflammatory cells in squamous and columnar epithelium before late after classic antireflux or acid suppression–duodenal diversion surgery. We evaluate impact these procedures presence intestinal metaplasia, dysplasia Helicobacter pylori epithelium. Two groups were studied, 37 subjected to 96 operations. They endoscopic studies at 1, 3 more than 5 years...
Background: Liver transplantation (LT) is an option for people with liver failure who cannot be cured other therapies and some cancer.
Background: The Chilean allocation system for liver transplantation (LT) uses the MELD/PELD score to prioritize candidates on waiting list.
Neurological complications following a liver transplantation. Experience from Chilean centerBackground: Orthotopic transplantation (OLT) is the treatment of choice for multiple acute and chronic end-stage diseases as well selected cases malignancy liver-site metabolic disorders.Neurological impairment major source morbidity mortality OLT.Aim: To describe incidence type neurological occurring in post-operative period OLT patients transplanted our hospital.Material methods : Between March 1994...
Antecedentes: El registro de los casos infección la herida operatoria (IHO) en el periodo hospitalización tiene un sesgo cuya magnitud no es conocido nuestro medio.El objetivo este trabajo medir incidencia IHO reparación primaria una hernia inguinal con malla mediante sistema vigilancia ambulatorio.Material y Método: Estudio longitudinal prospectivo serie pacientes sometidos a hernioplastía 22 meses protocolo completo.Todos se controlaron al 7°, 15°, 30° día del postoperatorio.Se utilizó...
Abstract Pancreatic cancer remains as one of the most aggressive human neoplasms, with overall poor survival rates. Radical surgery primary lesion is best option for treatment. Borderline resectable pancreatic tumors (BRPT), defined partial involvement peripancreatic vasculature, may benefit from neoadjuvant therapy. We report on first two BRPT cases treated chemoradiation at our institution. Preoperative CT and MRI demonstrated encasing porto-mesenteric confluence suggestive BRPT. Patients...