A5101398599- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Protein Degradation and Inhibitors
- Hippo pathway signaling and YAP/TAZ
- Acute Lymphoblastic Leukemia research
- Monoclonal and Polyclonal Antibodies Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Protein purification and stability
- Sarcoma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Retinoids in leukemia and cellular processes
- Salivary Gland Tumors Diagnosis and Treatment
- RNA Research and Splicing
- Immune Cell Function and Interaction
- Congenital heart defects research
- Genomics and Chromatin Dynamics
- Spinal Dysraphism and Malformations
- Cancer-related molecular mechanisms research
- Traumatic Brain Injury Research
- Pancreatic and Hepatic Oncology Research
- T-cell and B-cell Immunology
- Cerebrospinal fluid and hydrocephalus
- Inhalation and Respiratory Drug Delivery
University of Central Florida
2024-2025
Florida College
2024-2025
Vietnam National University of Agriculture
2025
Johns Hopkins University
2015-2024
Johns Hopkins Medicine
2015-2024
Nemours Children's Clinic
2024
University of Baltimore
2024
University of Florida
2023
University of Virginia
2020-2023
Baylor College of Medicine
2018-2022
Abstract Traumatic brain injury (TBI) is a leading global cause of death and disability. Here we demonstrate in an experimental mouse model TBI that mild forms trauma severe deficits meningeal lymphatic drainage begin within hours last out to at least one month post-injury. To investigate mechanism underlying impaired function TBI, examined how increased intracranial pressure (ICP) influences the lymphatics. We ICP can contribute dysfunction. Moreover, show pre-existing dysfunction before...
Abstract Tyrosine kinase inhibitors (TKIs) targeting FLT3 have shown activity but when used alone achieved limited success in clinical trials, suggesting the need for combination with other drugs. We investigated of TKIs (Gilteritinib or Sorafenib), Venetoclax, a BCL-2 selective inhibitor (BCL-2i), on FLT3/ITD leukemia cells. The TKI and BCL-2i synergistically reduced cell proliferation enhanced apoptosis/cell death lines primary AML samples. Venetoclax also re-sensitized TKI-resistant cells...
Autoimmune deficiency and destruction in either β-cell mass or function can cause insufficient insulin levels and, as a result, hyperglycemia diabetes. Thus, promoting proliferation could be one approach toward diabetes intervention. In this report we describe the discovery of potent selective DYRK1A inhibitor GNF2133, which was identified through optimization 6-azaindole screening hit. vitro, GNF2133 is able to proliferate both rodent human β-cells. vivo, demonstrated significant...
Rationale: During neonatal heart regeneration, the fibrotic response, which is required to prevent cardiac rupture, resolves via poorly understood mechanisms. Deletion of Hippo pathway gene Sav in adult cardiomyocytes increases Yap activity and promotes partly by inducing fibrosis resolution. leads increased loss suggesting that inhibits regulating intercellular signaling from fibroblasts (CFs). Objective: We investigated role Wntless ( Wls ), a direct target Yap, communication between CFs...
Neural crest cells (NCCs) are multipotent stem that can differentiate into multiple cell types, including the osteoblasts and chondrocytes, constitute most of craniofacial skeleton. Here, we show through in vitro vivo studies transcriptional regulators Yap Taz have redundant functions as key determinants specification differentiation NCCs or chondrocytes. Primary cultured deficient
Autoimmune diseases often result from inappropriate or unregulated activation of autoreactive T cells. Traditional approaches to treatment autoimmune through immunosuppression have focused on direct inhibition In the present study, we examined targeted antigen-presenting cells as a means downregulate immune responses and treat disease. Dendritic (DCs) are central for initiation cell responses, including ones. A large portion DCs derived hematopoietic progenitors that express FLT3 receptor...
// Bao Nguyen 1,* , Allen B. Williams David J. Young 1,2 Hayley Ma 1 Li Mark Levis Patrick Brown and Donald Small Department of Oncology, Johns Hopkins University School Medicine, Baltimore, MD, USA 2 Pediatrics * These authors have contributed equally to this work Correspondence to: Small, email: Keywords : acute myeloid leukemia, mutant FLT3, activation loop, tyrosine kinase inhibitors Received December 16, 2016 Accepted 25, Published January 06, 2017 Abstract Fms -like kinase-3 (FLT3) is...
Congenital plunging ranulas are pseudocystic lesions affecting the floor of mouth. This case report presents a two-month-old female with an asymptomatic unilateral cheek swelling, diagnosed multifocal congenital ranula. Magnetic resonance imaging, ultrasound, and fluoroscopy revealed atypical, multiseptated submandibular lesion sublingual salivary extensions. Needle aspiration yielded mucoid discharge, confirming diagnosis. The swelling was significantly reduced patient continued to achieve...
This study investigated the accumulation of nitrate and nitrite, as well vitamin C content, in various leafy vegetables, including amaranth greens, katuk, morning glory, squash leaves, vine spinach, leaf lettuce, romaine Vietnamese basil, perilla, komatsuna, leeks, grown with either organic or synthetic fertilizers. The findings indicate that type fertilizer significantly influences content these vegetables. Organic fertilizers were found to reduce levels increase spinach compared results...
The sinoatrial node (SAN) functions as the pacemaker of heart, initiating rhythmic heartbeats. Despite its importance, SAN is one most poorly understood cardiac entities because small size and complex composition function. Hippo signaling pathway a molecular fundamental to heart development regeneration. Although abnormalities are associated with arrhythmias in human patients, role this unknown.We investigated key regulators cells by conditionally inactivating kinases Lats1 Lats2 using...
Adipocytes contribute to metabolic disorders such as obesity, diabetes, and atherosclerosis. Prior characterizations of the transcriptional network driving adipogenesis have overlooked transiently acting transcription factors (TFs), genes, regulatory elements that are essential for proper differentiation. Moreover, traditional gene networks provide neither mechanistic details about individual element-gene relationships nor temporal information needed define a hierarchy prioritizes key...
Abstract The class III receptor tyrosine kinase FLT3 is expressed on the blasts of >90% patients with B-lineage acute lymphoblastic leukemias (ALL). In addition, it at extremely high levels in ALL mixed lineage leukemia rearrangements or hyperdiploidy and sometimes mutated these same patients. this report, we investigate effects treating cell lines primary samples human anti-FLT3 monoclonal antibodies (mAb) capable preventing binding ligand. vitro studies, examining ability two mAbs...
There have been a number of clinical trials testing the efficacy FMS-like tyrosine kinase-3 (FLT3) kinase inhibitors (TKI) in patients with acute myeloid leukemia (AML) harboring constitutively activating mutation FLT3. However, there has limited efficacy, most often because inadequate achievement FLT3 inhibition through variety mechanisms. In previous study, TTT-3002 was identified as novel inhibitor potent activity to date against internal tandem duplication (FLT3/ITD) mutations. Here, is...
// Kozo Nagai 1,* , Lihong Hou Li 1 Bao Nguyen Tessa Seale Courtney Shirley Hayley Ma Mark Levis Gabriel Ghiaur Amy Duffield 2 and Donald Small 1,3 Department of Oncology, Johns Hopkins University School Medicine, Baltimore, MD, USA Pathology, 3 Pediatrics, * contributed equally to this work Correspondence to: Small, email: donsmall@jhmi.edu Keywords : acute myeloid leukemia; FLT3; internal tandem duplication; tyrosine kinase inhibitor; arsenic trioxide Received: July 27, 2018 Accepted:...