A5007385907- Hippo pathway signaling and YAP/TAZ
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Congenital heart defects research
- Developmental Biology and Gene Regulation
- Cancer-related gene regulation
Baylor College of Medicine
2015-2022
The role of the Hippo signaling pathway in cranial neural crest (CNC) development is poorly understood. We used Wnt1Cre and Wnt1Cre2SOR drivers to conditionally ablate both Yap Taz CNC mice. When using either Cre driver, deficiency resulted enlarged, hemorrhaging branchial arch blood vessels hydrocephalus. However, embryos had an open tube phenotype that was not evident embryos. In O9-1 cells, loss impaired smooth muscle cell differentiation. RNA-sequencing data indicated regulate genes...
Neural crest cells (NCCs) are multipotent stem that can differentiate into multiple cell types, including the osteoblasts and chondrocytes, constitute most of craniofacial skeleton. Here, we show through in vitro vivo studies transcriptional regulators Yap Taz have redundant functions as key determinants specification differentiation NCCs or chondrocytes. Primary cultured deficient
The neural crest (NC) is a unique migratory stem cell population only existed during vertebrate embryogenesis. It has remarkable multipotency to give rise various types including osteoblasts and chondrocytes, which contribute majority of the cranial skeleton development. Defects in NC development led many congenital diseases, cleft palate craniofacial abnormities. Recently, Hippo-Yap pathway, conserved fundamental pathway been indicated play key role NCCs. Yet, roles Yap Taz, function as...
The neural crest cells (NCCs) are multipotent stem making pivotal contributions to many tissues and organs during embryonic development. NCCs have remarkable ability differentiate into various cell lineages including osteoblasts chondrocytes, yet it is largely unknown how make fate decisions specific lineages. Here we found Yap/Taz required for NCC-derived differentiation notably, deficiency caused switch from osteogenic chondrogenic in vitro. In vivo deletion cranial bone defects ectopic...