A5000931525- Genetic and Kidney Cyst Diseases
- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Hedgehog Signaling Pathway Studies
- Gastroesophageal reflux and treatments
- Craniofacial Disorders and Treatments
- Cleft Lip and Palate Research
- Dysphagia Assessment and Management
- Food Quality and Safety Studies
- Renal and related cancers
- dental development and anomalies
- Tea Polyphenols and Effects
- Congenital heart defects research
- Genetic Syndromes and Imprinting
- Cancer-related molecular mechanisms research
- Helicobacter pylori-related gastroenterology studies
- Epigenetics and DNA Methylation
- Respiratory and Cough-Related Research
- TGF-β signaling in diseases
- Cancer-related gene regulation
- Urological Disorders and Treatments
- Developmental Biology and Gene Regulation
- Eosinophilic Esophagitis
- NF-κB Signaling Pathways
The University of Texas Health Science Center at Houston
2014-2025
The University of Texas MD Anderson Cancer Center
2021-2024
Allegheny Health Network
2013-2022
Drexel University
2022
East Japan Railway (Japan)
2017-2020
Lung Institute
2015-2019
Western Pennsylvania Hospital
2012-2018
University of Michigan
2009-2017
National Institute of Environmental Health Sciences
2006-2017
Sidney Kimmel Comprehensive Cancer Center
2017
Oct4 and Sox2 are transcription factors required for pluripotency during early embryogenesis the maintenance of embryonic stem cell (ESC) identity. Functional mechanisms contributing to expected be associated with genes transcriptionally activated by these factors. Here, we show that bind a conserved promoter region miR-302, cluster eight microRNAs expressed specifically in ESCs pluripotent cells. The expression miR-302a is dependent on Oct4/Sox2 human (hESCs), at same developmental stages...
Abstract BMP signaling plays pleiotropic roles in various tissues. Transgenic mouse lines that overexpress a tissue‐specific manner would be beneficial; however, production of each transgenic line is labor‐intensive. Here, using Cre‐loxP system, we generated conditionally overexpressing for through the type I receptor ALK2 (alternatively known as AVCRI, ActRI, or ActRIA). By mating this with Cre‐expression lines, Cre‐mediated recombination removes an intervening floxed lacZ expression...
ABSTRACT Craniosynostosis describes conditions in which one or more sutures of the infant skull are prematurely fused, resulting facial deformity and delayed brain development. Approximately 20% human craniosynostoses thought to result from gene mutations altering growth factor signaling; however, molecular mechanisms by these cause craniosynostosis incompletely characterized, causative genes for diverse types syndromic have yet be identified. Here, we show that enhanced bone morphogenetic...
Significance Intraflagellar transport (IFT) plays a critical role in assembling primary cilia that mediate growth factor signaling. The disruption or dysfunction of IFT components can generate multiple diseases, including skeletal dysplasia. However, the mechanism by which regulates skeletogenesis remains elusive. In present study, we show neural crest-specific deletion gene encodes intraflagellar 20 (IFT20) mice compromises ciliogenesis and intracellular collagen, leading to osteopenia...
Magnetic sphincter augmentation (MSA) results in less severe side effects compared with Nissen fundoplication, but dysphagia remains the most common effect reported by patients after MSA. This study aimed to characterize and review management of postoperative identify preoperative factors that predict persistent is a retrospective prospectively collected data who underwent MSA between 2013 2018. Preoperative objective evaluation included upper endoscopy, esophagram, high-resolution impedance...
Protection of the stalled replication fork is crucial for responding to stress and minimizing its impact on chromosome instability, thus preventing diseases, including cancer. We found a new component, Abro1, in protection integrity. Abro1 deficiency results increased Abro1-null mice are tumor-prone. show that protects stability by inhibiting DNA2 nuclease/WRN helicase-mediated degradation forks. Depletion RAD51 prevents DNA2/WRN-dependent forks Abro1-deficient cells. This mechanism distinct...
Neural crest cells (NCCs) are multipotent stem that can differentiate into multiple cell types, including the osteoblasts and chondrocytes, constitute most of craniofacial skeleton. Here, we show through in vitro vivo studies transcriptional regulators Yap Taz have redundant functions as key determinants specification differentiation NCCs or chondrocytes. Primary cultured deficient
Stability of tea catechins during heat processing was examined. Effects pH and temperature on reaction kinetics degradation were investigated. Reaction – EC accelerated at higher than 6.0, inhibited those lower 5.0. A dominant in slightly acidic media isomerization. The apparent first order proceeded under sterilization conditions. similar for EC, EGC, ECg, EGCg green infusion temperatures below 95°C. turning point an Arrhenius plot observed 82°C. great difference activation energies rate...
Bone morphogenetic protein (BMP) signaling plays many roles in skull morphogenesis. We have previously reported that enhanced BMP through the type IA receptor (BMPR1A) cranial neural crest cells causes craniosynostosis during postnatal development. Additionally, we observed 55% of Bmpr1a mutant mice show neonatal lethality characterized by a distended gastrointestinal tract. Here, severely affected mutants exhibit defective nasal cartilage, failure fusion between septum and secondary palate,...
Cranial neural crest cells (CNCCs) are a population of multipotent stem that give rise to craniofacial bone and cartilage during development. Bone morphogenetic protein (BMP) signaling autophagy have been individually implicated in cell homeostasis. Mutations cause constitutive activation the BMP type I receptor ACVR1 congenital disorder fibrodysplasia ossificans progressiva (FOP), which is characterized by ectopic connective tissues trunk sometimes includes bones. Here, we showed enhanced...
TAK1 kinase is an indispensable intermediate in several cytokine signaling pathways including tumor necrosis factor, interleukin-1, and transforming growth factor-beta pathways. also participates stress-activated intracellular such as osmotic stress pathway. TAK1-binding protein 1 (TAB1) constitutively associated with through its C-terminal region. Although TAB1 known to augment catalytic activity when it overexpressed, the role of under physiological conditions has not yet been identified....
Abstract Bone morphogenetic proteins (BMPs) have multiple roles during embryogenesis. Current data indicate that the dosage of BMPs is tightly regulated for normal development in mice. Since Bmp2 or Bmp4 homozygous mutant mice show early embryonic lethality, we generated compound heterozygous and to explore impact lowered these BMP ligands. Genotyping pups bred between revealed ratio adult much lower than expected. During embryogenesis, embryos showed several abnormalities, including defects...
Chronic cough is a laryngeal symptom that can be caused by gastroesophageal reflux disease; however, treatment outcome has been difficult to predict because of the lack an objective testing modality accurately detects reflux-related cough.To define patterns and assess antireflux surgery (ARS) in patients with chronic who were selected using hypopharyngeal multichannel intraluminal impedance (HMII).Review prospectively collected data.Tertiary care university hospital.Patients cough, which was...
P0-Cre and Wnt1-Cre mouse lines have been widely used in combination with loxP-flanked mice to label genetically modify neural crest (NC) cells their derivatives. has regarded as the gold standard there concerns about specificity of because it is not clear timing spatial distribution transgene labeling NC at early embryonic stages. We re-visited models embryos a focus on cranial NC. found that R26-lacZ Cre reporter responded activity more reliably than CAAG-lacZ during embryogenesis....
To determine the patterns and proximity of reflux events in patients with adult-onset asthma (AOA) using hypopharyngeal multichannel intraluminal impedance (HMII) to assess outcomes antireflux surgery (ARS) AOA. DESIGN Retrospective review prospectively collected data.University hospital. PATIENTS, INTERVENTIONS, AND OUTCOMES: All AOA referred our testing center underwent HMII, those abnormal proximal exposure, defined as laryngopharyngeal at least once a day and/or high esophageal 5 times...
SUMMARY Volumetric laser endomicroscopy (VLE) uses optical coherence tomography (OCT) for real-time, microscopic cross-sectional imaging. A US-based multi-center registry was constructed to prospectively collect data on patients undergoing upper endoscopy during which a VLE scan performed. The objective of this determine usage patterns in clinical practice and estimate quantitative qualitative performance metrics as they are applied Barrett's esophagus (BE) management. All procedures...
Magnetic sphincter augmentation (MSA) is an effective treatment for patients with gastroesophageal reflux disease. In early studies, a hiatal hernia (HH) ≥ 3 cm were excluded from consideration implantation and initially the FDA considered its use as "precautionary" in this context. This approach has led to attitude of hesitance among some surgeons offer therapy HH. study was designed evaluate impact HH status on outcome MSA report rate recurrence after MSA.This retrospective review...
Idiopathic pulmonary fibrosis (IPF) is a diffuse fibrotic lung disease of unknown etiology. The association between IPF and gastroesophageal reflux (GERD) has been suggested. objective this study was to determine the prevalence GERD assess proximity events in patients with histologically proven using hypopharyngeal multichannel intraluminal impedance (HMII). This retrospective review prospectively collected data from confirmed (via biopsy) who underwent esophageal physiology testing...