A5022572792- Analytical Chemistry and Chromatography
- Microfluidic and Capillary Electrophoresis Applications
- Analytical Methods in Pharmaceuticals
- Mass Spectrometry Techniques and Applications
- Crystallization and Solubility Studies
- Viral Infections and Vectors
- Salmonella and Campylobacter epidemiology
- Virology and Viral Diseases
- Pharmacogenetics and Drug Metabolism
- Intellectual Property and Patents
- Asymmetric Synthesis and Catalysis
- Treatment of Major Depression
- Cavitation Phenomena in Pumps
- Amino Acid Enzymes and Metabolism
- Cancer Treatment and Pharmacology
- Synthesis and pharmacology of benzodiazepine derivatives
- Diet and metabolism studies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Forensic Fingerprint Detection Methods
- Respiratory viral infections research
- Drug Transport and Resistance Mechanisms
- Nausea and vomiting management
- Antibiotic Resistance in Bacteria
- Pharmacological Effects and Assays
- Rice Cultivation and Yield Improvement
Bangladesh Agricultural University
2022-2024
Bangladesh University of Engineering and Technology
2023
TransCanada (Canada)
2014
Institute of Epidemiology, Disease Control and Research
2008
Ministry of Health and Family Welfare
2007
University of Wales
1997
King Faisal Specialist Hospital & Research Centre
1988-1992
Abstract Nipah virus (NiV) is a paramyxovirus that causes severe encephalitis in humans. During January 2004, twelve patients with NiV (NiVE) were identified west-central Bangladesh. A case–control study was conducted to identify factors associated infection. NiVE from the outbreak enrolled matched case-control study. Exact odds ratios (ORs) and 95% confidence intervals (CIs) calculated by using analysis. Climbing trees (83% of cases vs. 51% controls, OR 8.2, CI 1.25–∞) contact another...
We conducted a seroprevalence study and exposure survey of healthcare workers to assess the risk nosocomial transmission Nipah virus during an outbreak in Bangladesh 2004. No evidence recent infection was detected despite substantial exposures minimal use personal protective equipment.
Abstract A newly developed and commercially available cellulose tris-4-methylphenyl benzoate (Chiralcel OJ) chiral stationary phase was used for the enantiomeric resolution of thalidomide enantiomers. simple isocratic direct liquid chromatographic racemic accomplished without any derivatization. Solvent system hexane ethanol (50:50) with flow rate 1 ml/min. at 23°C. capacity factor (k') first eluted enantiomer R-(+)-thalidomide 9.67 separation (α) obtained 1.54. maximum stereochemical (R)...
Abstract Penbutolol is a β‐adrenoceptor blocking agent, and it contains the clinically relevant (−)‐S‐enantiomer. It was reported that (+)‐R‐enantiomer of penbutolol pharmacologically 50 times less active than (−)‐S‐isomer in β‐sympatholysis without intrinsic sympathomimetic activity refractory period heart muscle. Furthermore, does possess mutagenic activity. A high‐performance liquid chromatographic (HPLC) method described for direct identification, stereochemical separation, quantitation...
Abstract The structural factors and functional group selectivity requirements affecting direct high-performance liquid chromatographic enantiomeric resolution of drug racemates on several derivatized cellulose chiral stationary phases are reviewed. A guide for the choice appropriate derivative column based elements asymmetry groups compounds presented.
Abstract Celiprolol enantiomers were resolved without any derivatization using a high performance liquid chromatographic system on cellulose tris-3, 5-dimethylphenyl carbamate column (CHIRALCEL-OD). Maximum stereochemical resolution (R) obtained with symmetrical peaks was 2.94. The effects of 2-propanol and diethylamine content in mobile phas'e, effect temperature capacity factor (k), separation (α) are demonstrated.
Journal Article Isocratic High-Performance Liquid Chromatographic Resolution of Glutethimide Enantiomers and Their 4-Hydroxyglutethimide Metabolites Using Cellulose Tribenzoate Chiral Stationary Phase Get access Hassan Y. Aboul-Enein, Aboul-Enein * Drug Development Laboratory, Radionuclide & Cyclotron Operations Department, King Faisal Specialist Hospital Research Centre, P.O. Box 3354, Riyadh 11211, Kingdom Saudi Arabia *Author to whom correspondence should be addressed. Search for other...
Abstract A direct liquid chromatographic method was developed for the optimization of separation racemic S, R-nomifensine hydrogen maleate, a psychotropic drug, this achieved without any derivatization, using β-cyclodextrin-bonded phase column. factor 1.46 and resolution 4.30 were obtained enantiomers nomifensine maleate. The effect pH, temperature methanol content in mobile on retention enantioselectivity maleate also demonstrated.
Abstract Direct liquid chromatographic resolution and optimization of carazolol are accomplished without any derivatizations on a cellulose tris-3, 5-dimethylphenyl carbamate column (known as OD-CHIRALCEL). Maximum stereochemical (R) 2.2 is obtained. The effects 2-propanol diethylamine content in mobile phase effect temperature capacity factor (k), separation (α) demonstrated.
Abstract A commercially available microcrystalline cellulose triacetate (CA-1) chiral stationary phase was used for the enantiomeric resolution of ketamine [(±)-2-(2-chlorophenyf)-2-methylaminocyclohexanone]. simple isocratic and direct liquid chromatographic racemic accomplished without derivatization, using pure ethanol as eluent with flow rate 1 ml/min at 25°C. The elution order determined by chromatographing separate enantiomers under similar conditions. capacity factor (k) first eluted...
Abstract Direct chiral liquid chromatographic resolution of racemic tocainide was accomplished without any derivatization using a crownpak CR(+) column as stationary phase. The stereochemical (R) with symmetrical peaks 0.97 and separation factor (α) 1.44 were obtained. Optimization achieved different concentrations perchloric acid.
A 10-cm long alpha 1-acid glycoprotein column is used for the enantiomeric resolution of clinically racemic aminoglutethimide (+/- AG) and its acetylated metabolite AAG). direct liquid chromatographic accomplished without any derivatizations. Maximum resolutions 1.37 0.73 are obtained enantiomers metabolite, respectively. The effect 2-propanol content in mobile phase on retention enantioselectivity demonstrated. variation separation factors (alpha) with pH also shown.
Abstract A direct, isocratic, sensitive and precise liquid chromatographic method is presented for the enantiomeric separation of aminoglutethimide (AG) its acetylated metabolite (AcAG) using cellulose tris‐3,5‐dimethyl phenyl carbamate (Chiralcel OD) tris(4‐methylphenyl benzoate) ester OJ) columns in series. The elution order determined by separate chromatography racemate AG AcAG their enantiomers under similar conditions. This has been used to determine identify urine sample collected from...
Escherichia coli is a significant foodborne pathogen, frequently linked to hemorrhagic diarrhea, especially in developing nations, where it presents considerable public health concerns. This study was conducted examine the virulence gene profiles and antibiotic resistance patterns of E. strains isolated from piper betel leaves. A total 100 leaf samples, including fresh (n = 60) ready-to-eat 40) specimens, were collected tested for presence using standard diagnostic techniques, such as...
A sensitive, accurate and reproducible method for the analysis of ranitidine in pharmaceutical preparations has been described. An isocratic HPLC elution was employed which requires about 10 minutes to be performed. The concentration hydrochloride found 98.19±0.02% 98.33±0.04% Zantac® Apo‐ranitidine® tablets, respectively.
Background and Aim: Campylobacter infections in sheep may be asymptomatic or cause enteritis, ileitis, infertility, abortion. Thus, this study aimed to estimate the prevalence of spp. farming detect risk factors, molecular patterns, antimicrobial susceptibility status these pathogens. Materials Methods: Four hundred eight fecal samples were collected from 12 flocks Mymensingh Sherpur districts. Samples tested by both basic (culture biochemical tests) (initially 16S rRNA later hipO gene-based...
Reducing methane (CH4) emissions and water use in irrigated rice systems while maintaining production to feed the ever-increasing population is vital Bangladesh. Different establishment methods viz. alternate wetting & drying (AWD), system intensification (SRI) direct wet seeded (DWSR), have a promising mitigation potential reduce CH4emission compared continuous flooded (CF) fields. A field experiment was conducted at Bangladesh Agricultural University, Mymensingh, during Boro season...
A sensitive, accurate and reproducible method for the analysis of metoclopramide, a gastrointestinal drug, has been described. An isocratic HPLC elution was employed which requires about 10 minutes to be performed. The concentration metoclopramide hydrochloride preparations found 95.1 ±0.3% 94.21 ±0.25% in tablet injection formulations, respectively.
A sensitive, accurate and reproducible method for the analysis of EG (Ethylene Glycol) in stamp pad ink sample has been described. An isocratic HPLC elution was employed which requires about 5 minutes to be performed. The concentration these samples were found 3.7+0.02%. limit detection this 0.029 μl.