A5050973417- Enzyme function and inhibition
- Renin-Angiotensin System Studies
- Hemoglobin structure and function
- Inflammasome and immune disorders
- Virus-based gene therapy research
- Herpesvirus Infections and Treatments
- interferon and immune responses
- Cholinesterase and Neurodegenerative Diseases
- Viral Infections and Vectors
- Adenosine and Purinergic Signaling
- Nitric Oxide and Endothelin Effects
University of Naples Federico II
2023-2025
Ceinge Biotecnologie Avanzate (Italy)
2021-2025
Different innate immune pathways converge to Stimulator of interferon genes (STING) and trigger type I responses after recognition abnormal nucleic acids in the cells. This non-redundant function renders STING a major player immunosurveillance, an emerging target for cancer infectious diseases therapeutics. Beyond somatic mutations that often occur cancer, human gene encoding protein, TMEM173 (STING1), holds great genetic heterogeneity; R232, HAQ (R71H-G230A-R293Q) H232 are most common...
Carbonic anhydrases constitute a family of metalloenzymes vital for maintaining acid-base balance and regulating pH in physio-pathological processes. These findings suggest carbonic as potential therapeutic targets treating pH-associated disorders, including cerebral ischemia, to mitigate hypoxia- reoxygenation-induced neuronal damage. A focus on anhydrase IX showed that ischemic stress altered subcellular distributions this enzyme rodent populations. Given the enzyme's canonical membrane...
The human carbonic anhydrase IX (CA IX) is a hypoxia-induced transmembrane protein belonging to the α-CA enzyme family. It has crucial role in pH regulation hypoxic cells and acts by buffering intracellular acidosis induced hypoxia. Indeed, it frequently expressed cancer cells, where contributes tumor progression. CA also able localize nucleus, 47S rRNA precursor genes transcription; however, mechanisms assisting its nuclear translocation still remain unclear. aim of our study was deepen...
Background: Oncolytic viruses are immunotherapeutic agents that can be engineered to encode payloads of interest within the tumor microenvironment enhance therapeutic efficacy. Their potential could limited by many avenues for immune evasion exerted tumor. One such is mediated adenosine, which induces pleiotropic immunosuppression inhibiting antitumor populations as well activating tolerogenic stimuli. Adenosine produced starting from highly immunostimulatory ATP, progressively hydrolyzed...