A5029283632- Prostate Cancer Treatment and Research
- Metabolomics and Mass Spectrometry Studies
- Advanced Proteomics Techniques and Applications
- Molecular Biology Techniques and Applications
- HIV/AIDS drug development and treatment
- Mosquito-borne diseases and control
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- HIV Research and Treatment
- Hormonal and reproductive studies
- Metabolism and Genetic Disorders
- Cancer-related gene regulation
- Mass Spectrometry Techniques and Applications
- Multiple Myeloma Research and Treatments
- HIV-related health complications and treatments
- Cancer Mechanisms and Therapy
- Cancer therapeutics and mechanisms
- Prostate Cancer Diagnosis and Treatment
University of Maryland, Baltimore County
2018-2024
John Wiley & Sons (United States)
2018
Hudson Institute
2018
Efavirenz (EFV) is a commonly used drug to treat human immunodeficiency virus infection and known exert adverse effects on the brain. Although it that EFV associated with abnormal plasma lipid levels, changes in spatial localization of individual molecules brain tissue following treatment are yet be explored. In this study, we employed matrix-assisted laser desorption/ionization mass spectrometry imaging approach determine region-specific alterations mouse brains treatment. We detected...
Abstract Background Advanced prostate cancers depend on protein synthesis for continued survival and accelerated rates of metabolism growth. RNA polymerase I (Pol I) is the enzyme responsible ribosomal (rRNA) transcription a rate‐limiting step ribosome biogenesis. We have shown using specific sensitive probe 45S rRNA precursor that increased in adenocarcinoma compared to nonmalignant epithelium. introduced first‐in‐class Pol inhibitor, BMH‐21, targets cancer cells multiple origins, holds...
Aberrant activation of Ras/Raf/mitogen-activated protein kinase (MAPK) signaling is frequently linked to metastatic prostate cancer (PCa); therefore, the characterization modulators this pathway critical for defining therapeutic vulnerabilities PCa. The lysine methyltransferase SET and MYND domain 3 (SMYD3) methylates MAPK 2 (MAP3K2) in some cancers, causing enhanced signaling. In PCa, SMYD3 overexpressed associated with disease severity; however, its molecular function promoting...
Provirus integration site for Moloney murine leukemia virus (PIM) family serine/threonine kinases perform protumorigenic functions in hematologic malignancies and solid tumors by phosphorylating substrates involved tumor metabolism, cell survival, metastasis, inflammation, immune invasion. However, a comprehensive understanding of PIM kinase is currently lacking. Multiple small-molecule inhibitors are being evaluated as cotherapeutics patients with cancer. To further illuminate cancer, we...
Background: Loss or mutation of PTEN alleles at 10q23 in combination with 8q24 amplification (encompassing MYC ) are common findings aggressive, human prostate cancer. Our group recently developed a transgenic murine model cancer involving prostate‐specific Pten deletion and forced expression under the control Hoxb13 promoter. overexpression cooperated loss to recapitulate lethal, Method: We now report on generation two mouse cell lines, BMPC1 BMPC2, derived from lymph node, liver...
Abstract Prostate cancer kills 30,000 men per year in the U.S. Yet, of all primary prostate cancers, only a relatively small percentage are aggressive and have potential to become life threatening. In terms genomic copy number alterations, concurrent amplification MYC loss tumor suppressor PTEN is strongest predictor specific mortality. We previously shown, novel mouse model, that combined overexpression Pten results development precursor lesions (PIN) lead metastatic prostatic...
<b>Abstract ID 129701</b> <b>Poster Board 042</b> Efavirenz (EFV) is a non-nucleoside reverse transcriptase inhibitor used for human immunodeficiency virus (HIV) treatment in combination with other antiretrovirals such as tenofovir and emtricitabine. Notably, EFV has been listed the World Health Organization's list of essential medicines. However, previous clinical studies have revealed that associated adverse effects on brain. Since lipids play diverse physiological roles brain, their...