A5013203696- Skin Protection and Aging
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Neurotransmitter Receptor Influence on Behavior
- Bee Products Chemical Analysis
- Telomeres, Telomerase, and Senescence
- Ion channel regulation and function
- Antioxidant Activity and Oxidative Stress
- Genetic and rare skin diseases.
- Neuroscience and Neuropharmacology Research
- Cardiac electrophysiology and arrhythmias
- melanin and skin pigmentation
- Pharmacological Receptor Mechanisms and Effects
- Hedgehog Signaling Pathway Studies
- Vitamin C and Antioxidants Research
- Protein Kinase Regulation and GTPase Signaling
- Cancer and Skin Lesions
- Advancements in Transdermal Drug Delivery
Pierre Fabre (France)
2008-2024
Intrinsic and extrinsic factors, including lifestyle sun exposure, can contribute to cell senescence, which impairs skin homeostasis, that may in turn lead aging. Senescent cells have a specific secretome, called the senescence-associated secretory phenotype (SASP) includes MMPs, CXCLs S100A8/9. Reducing SASP with senotherapeutics is promising strategy reduce Here we evaluated effect of formula containing niacinamide hyaluronic acid, are known limit senescence We conducted three different...
Abstract The Hedgehog ( HH ) pathway has been linked to the formation of basal cell carcinoma BCC ), medulloblastoma, and other cancers. recently approved orally active drugs vismodegib GDC ‐0449) sonidegib LDE –225) were not only efficacious for treatment advanced or metastatic by antagonizing smoothened SMO receptor, but also produced important side effects, limiting their use less invasive . Herein, we compared a large series antagonists, including ‐0449 ‐225, clinically tested BMS...
Deleterious effects of pollutants and ultraviolet radiation on the skin can be attenuated using formulations containing antioxidants. However, these have disadvantages, including chemical instability, photodegradation, poor bioavailability or biological activity. Here, two commercial were evaluated: one optimized to stabilize deliver ascorbic acid (AA) at 15% other a glucoside form AA, namely 2-glucoside (AA2G), 1.8% physiological pH. We compared delivery, antioxidative stability AA2G with...
We report the discovery of a new family α(2) adrenergic receptor antagonists derived from atipamezole. Affinities compounds at human and α(1b) receptors as well their functional activities hα(2A) were determined in competition binding G-protein activation assays, respectively. Central antagonist confirmed mice after oral administration. Further studies on selected example: (+)-4-(1a,6-dihydro-1H-cyclopropa[a]inden-6a-yl)-1H-imidazole, (+)-1 (F 14805), undertaken to probe potential series. On...
We investigated the dermal bioavailability and antioxidative properties of a sunscreen formulation containing two antioxidants, oxothiazolidine (OTZ) δ-tocopheryl glucoside (DTG). OTZ reacts directly with reactive oxygen species to form taurine, while DTG is metabolized in δ-tocopherol achieve activities.After topical application hair follicle-derived reconstructed human epidermis (RHE) model, followed by solar-simulated radiation, kinetics responses were measured over 24 h. Markers for...