A5101702062- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Natural Compound Pharmacology Studies
- Protein Degradation and Inhibitors
- Emergency and Acute Care Studies
- Phytochemistry and Biological Activities
- Child and Adolescent Health
- Immune cells in cancer
- Immune Response and Inflammation
- Pancreatic function and diabetes
- Neuroinflammation and Neurodegeneration Mechanisms
- Migration, Health and Trauma
- Synthesis of Organic Compounds
Ministry of Defence
2024
National Center for Drug Screening
2024
Shanghai Institute of Materia Medica
2024
Nantong University
2015
Impeded autophagy can impair pancreatic β cell function by causing apoptosis, of which DAP-related apoptosis-inducing kinase-2 (DRAK2) is a critical regulator. Here, we identified marked up-regulation DRAK2 in tissue across humans, macaques, and mice with type 2 diabetes (T2D). Further studies showed that conditional knockout (cKO) cells protected against high-fat diet feeding along sustained mitochondrial function. Phosphoproteome analysis isolated mouse primary islets revealed directly...
INTRODUCTION Over the past decade, paramedicine has been formalised in many countries, gaining recognition as a fully accredited health profession various systems countries such Australia and United Kingdom.[1] The evolution of also seen gradual establishment re-evaluation clinical practice guidelines, regulatory frameworks tertiary-level academic research courses.[2] In Singapore, Singapore Civil Defence Force provides nationwide emergency medical services (EMS), it is fire-based system...