A5047552166- Blood Coagulation and Thrombosis Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Protease and Inhibitor Mechanisms
- Folate and B Vitamins Research
- Hemophilia Treatment and Research
- Vascular anomalies and interventions
- Blood properties and coagulation
- Cerebral Venous Sinus Thrombosis
- Cardiovascular Issues in Pregnancy
- Microscopic Colitis
- Advanced Biosensing Techniques and Applications
- Acute Lymphoblastic Leukemia research
- Prostate Cancer Diagnosis and Treatment
- Acute Myocardial Infarction Research
- Pregnancy and preeclampsia studies
- Inflammatory Bowel Disease
- Prostate Cancer Treatment and Research
- Lipoproteins and Cardiovascular Health
- Cell Adhesion Molecules Research
- Intracranial Aneurysms: Treatment and Complications
- Clinical Laboratory Practices and Quality Control
- Esophageal and GI Pathology
- Menopause: Health Impacts and Treatments
- Methemoglobinemia and Tumor Lysis Syndrome
- Protein Degradation and Inhibitors
Max Planck Institute of Biochemistry
2024
University Hospital Schleswig-Holstein
2014-2022
University of Lübeck
2014-2022
Universitäts Hautklinik Kiel
2022
Kiel University
2021
University of Münster
1997-2008
Institute of Art
1999-2004
Institute of Clinical Research
2004
Boston Children's Hospital
2002
University Hospital Münster
1999-2001
Abstract Transmembrane E3 ligases play crucial roles in homeostasis. Much protein and organelle quality control, metabolic regulation, are determined by ER-resident MARCH6 ligases, including Doa10 yeast. Here, we present Doa10/MARCH6 structural analysis cryo-EM AlphaFold predictions, a structure-based mutagenesis campaign. The majority of adopts unique circular structure within the membrane. This channel is established lipid-binding scaffold, gated flexible helical bundle. ubiquitylation...
The factor V (FV) G1691A mutation, the prothrombin (PT) G20210A variant, methylenetetrahydrofolate reductase (MTHFR) T677T genotype, together with fasting homocysteine (HCY) concentration, lipoprotein (Lp)(a), anti-thrombin (AT), protein C (PC), S (PS) and anti-cardiolipin antibodies were investigated in 65 consecutively recruited infants (neonate to < 12 months) renal venous thrombosis (RVT; n = 31), portal vein (PVT; 24) or hepatic (HVT 10), 100 age- sex-matched healthy controls. FV was...
Objective: Recently, an association between the homozygous C677T mutation in methylenetetrahydrofolate reductase (MTHFR) gene infants with congenital neural tube defects or oral clefts has been shown. However, no data are available so far respect to MTHFR 677TT genotype children underlying structural heart disease (CHD). Methods: We investigated 114 Caucasian CHD patients aged newborn 16 years (median 0.6 years; 53% male) and 228 age- sex-matched healthy controls. Results: In childhood was...
Background Plasma concentrations of D-dimers show the extent intravascular fibrinolysis cross-linked fibrin. Higher are found in plasma arteriosclerosis patients with increased fibrin metabolism. The present study was performed order to investigate whether there is a relationship between severity and fibrinolytic activity indicated by levels D-dimer.
Hereditary prothrombotic risk factors have been shown to increase the of venous thrombosis in children treated with combination E. coli asparaginase and steroids. In present study role ALL according COALL protocol was investigated 108 consecutively recruited childhood patients. The prevalence rates [factor V G1691A mutation, prothrombin G20210A variant, TT677 methylenetetrahydrofolate reductase genotype, deficiencies protein C, S, antithrombin, elevated lipoprotein (a)] this cohort were...
Summary In this study we found that HDL acts as a potent and specific mitogen in vascular smooth muscle cells (VSMC) by stimulating entry into S-phase DNA synthesis time- concentration-dependent manner, induction of cyclins D1, E, A, well activation cyclin D-dependent kinases inferred from phosphorylation the retinoblastoma protein (pRb). Moreover, induced mitogen-activated kinase pathway including Raf-, MEK-1, ERK1/2, expression proto-oncogen c-fos, which is controlled ERK1/2. PD98059, an...
BACKGROUND: The large differences in cardiovascular disease rates between Eastern and Western Europe have largely developed over the last few decades, are only partly explained by classical risk factors. This study was set up to identify other potential determinants of these differences. METHODS: an ecological comparing random samples men aged 45-64 years selected from three cities representing populations with different mortality: Pardubice (Czech Republic), Augsburg (Bavaria, Germany),...
OBJECTIVE Hormone replacement therapy (HRT) is usually prescribed as medium‐ to high‐dose formulations. Little known, however, about dose‐dependency of oestrogen effects on plasma hormone levels, markers cardiovascular risk in lipid metabolism and the haemostatic system, or bone turnover. SUBJECTS AND DESIGN In an open trial, three groups 12 13 healthy, non‐obese postmenopausal women received conjugated equine oestrogens (CEE) for 6 months at doses 0.3 mg/day (group 1), 0.6 2) 1.25 3). From...
Background and Purpose— Observations in patients with arterial aneurysms, fibromuscular dysplasia, spontaneous cervical artery dissection (sCAD) indicate that protease inhibitor deficiency might boost the enzymatic destruction of tissue increase risk these wall diseases. Here we present first large investigation hypothesis sCAD. Methods— Eighty sCAD were compared 80 age- sex-matched healthy individuals. α 1 -antitrypsin (α -AT) 2 -macroglobulin -MG) levels, -AT genotypes assessed between...
Background: The present study was designed to prospectively evaluate the role of prothrombotic risk factors in leukemic children treated according ALL-BFM 90/95 protocols with respect onset cerebral venous sinus thrombosis.
Several recent studies have reported contradicting results concerning the relevance of plasminogen activator inhibitor-1 (PAI-1) 4G/5G-polymorphism for myocardial infarction. In addition, common factor V Q506 (FV:Q506) mutation is frequently discussed as a risk arterial thrombosis, but evidence rare. order to further highlight role both polymorphisms in infarction, we investigated 241 young male infarction patients (≤ 45 years-of-age) aged 38.6 ± 4.4 years (mean SD) presence genotypes. The...
Spontaneous cervical arterial dissection is an important cause of juvenile stroke. However, etiopathology and genetic background remain poorly understood. We report on a 45-year-old-male patient with homozygous alpha-1-antitrypsin (alpha-1-AT) deficiency in whom internal carotid artery occurred the absence any other known risk factors. The relevance alpha-1-AT for spontaneous dissections discussed.