A5028560017- Diet and metabolism studies
- Fatty Acid Research and Health
- Peroxisome Proliferator-Activated Receptors
- Adipose Tissue and Metabolism
- Antioxidant Activity and Oxidative Stress
- Metabolomics and Mass Spectrometry Studies
- Cancer, Lipids, and Metabolism
- Alcohol Consumption and Health Effects
- Metabolism and Genetic Disorders
- Platelet Disorders and Treatments
- Biochemical Analysis and Sensing Techniques
- Free Radicals and Antioxidants
- Diet, Metabolism, and Disease
- Lipid metabolism and biosynthesis
- Inflammatory mediators and NSAID effects
- Gastrointestinal motility and disorders
- Eicosanoids and Hypertension Pharmacology
- Antiplatelet Therapy and Cardiovascular Diseases
- Muscle metabolism and nutrition
- Immune Response and Inflammation
- Cholesterol and Lipid Metabolism
- Breastfeeding Practices and Influences
- Macrophage Migration Inhibitory Factor
- Birth, Development, and Health
- Consumer Attitudes and Food Labeling
Firmenich (Switzerland)
2023
Nestlé (Switzerland)
1999-2018
Imperial College London
2005-2006
Nestlé (China)
2006
Wuhan Institute of Physics and Mathematics
2006
Chinese Academy of Sciences
2006
Vanderbilt University Medical Center
2002
The University of Texas at Austin
1997
University of Guelph
1993-1994
University of Alberta
1991
The increased availability of saturated lipids has been correlated with development insulin resistance, although the basis for this impairment is not defined. This work examined interaction and unsaturated fatty acids (FA) stimulation glucose uptake its relation to FA incorporation into different lipid pools in cultured human muscle. It shown that basal or insulin-stimulated 2-deoxyglucose was unaltered cells preincubated oleate, whereas response impaired palmitate- stearate-loaded cells....
ABSTRACT Objectives: Psychological stress during the neonatal period results in intestinal barrier dysfunction and growth alterations later life. We aimed to restore impaired function rate by a nutritional intervention. Methods: Male rat pups (n = 84) were assigned 1 of 2 rearing conditions from postnatal day (PND) PND14: S, separated 3 h/d their mothers, or H, 15 min/d handled controls. From PND15 PND35, rats received control diet similar adapted contain arachidonic docosahexaenoic acids,...
This study aims to determine if isoprostanes accurately reflect in vivo lipid peroxidation or whether they are influenced by the content of diet. Isoprostanes were measured urine healthy subjects under different conditions intake and oxidative stress (fasting). We found that not diet: urinary level remained constant over 24 h as well 4 consecutive days when switching from high low intake. Urinary isoprostane excretion was increased 40% following a fast. concluded reflects endogenous vivo.
Stress in the form of moderate periods maternal separation newborn rats has been postulated to cause permanent changes central nervous system and diseases later life. It is also considered that dietary supplementation with long chain polyunsaturated fatty acids (LC-PUFAs) can potentially ameliorate effects stress. The metabolic consequences early life stress were investigated (2-14 days after birth), either alone or combination secondary acute water avoidance at 3-4 months age. effect a...
We report details of metabolic profiles for small intestinal samples obtained using high-resolution magic-angle-spinning (HRMAS) (1)H NMR spectroscopy. Intact jejunum and ileum from male Long Evans rats were analyzed on a 600 MHz spectrometer standard one two-dimensional spectroscopic pulse sequences. The predominantly comprised number amino acids, lipids, glycerophosphocholine (GPC), choline, creatine, ethanol, carboxylic acids including acetate lactate, nucleoside bases cytosine,...
Most preterm infant formulas contain medium-chain triacylglycerols (M80), but the effects of MCT on polyunsaturated fatty acid status and metabolism are controversial. Thus, we studied linoleic using stable isotopes. Enterally fed infants were randomized to receive for 7 days 40% fat as (n = 10) or a formula without 9). At study day 5, received orally 2 mg/kg body weight 13C-labeled acid. Fatty acids in plasma lipid classes 13C enrichment phospholipid measured tracer oxidation was monitored....
Abstract Background Insulin resistance induced by a high fat diet has been associated with alterations in lipid content and composition skeletal muscle adipose tissue. Administration of β3-adrenoceptor (β3-AR) agonists was recently reported to prevent insulin diet, such as the cafeteria diet. The objective present study determine whether selective β3-AR agonist (ZD7114) could profile tissue lipids Methods Male Sprague-Dawley rats fed were treated orally either ZD7114 (1 mg/kg per day) or...
Abstract Purpose This study investigates intakes of risk micronutrients from non-fortified foods, fortified foods and food supplements in different age gender sub-groups the Dutch population. Methods is a secondary analysis National Food Consumption Survey (DNFCS 2012–2016, N = 4313, 1–79 years). The proportion population with Habitual Intakes below Estimated Average Requirement (EAR) above Upper Level (UL) for calcium, iron, zinc, vitamin A, B6, folate, D E total intake including was...
Digestive motility was studied in the rat using a miniaturized version of Magnet Tracking system which monitored progression small magnetic pill through entire digestive tract. The dynamics movement followed and three-dimensional (3-D) images tract were generated. After retention period stomach rapid passage duodenum, magnet progressed along intestine with gradually decreasing speed longer stationary periods. It remained caecum for variable intervals. In colon, periods progress alternated...
Ibuprofen and antibiotics are commonly prescribed during early childhood. When given to mice at the time which oral tolerance is induced, both treatments affect either induction or maintenance of tolerance. These results suggest that coadministration these similarly acting drugs should be considered cautiously for infants risk allergy.
Collagen-induced human platelet stimulation is dependent on the release of arachidonic acid (AA) from membrane phospholipid and formation thromboxane A2 (TxA2) for TxA2-induced activation. Since plasmenylethanolamine represents single major reservoir AA in resting platelets, we assessed its hydrolysis via phospholipase upon with low levels collagen by determining generation [3H]lysoplasmenylethanolamine eicosanoid/TxA2-independent -dependent processes. Ethanolamine phospholipids platelets...
Abstract To examine whether dietary fat alters membrane lipid composition and peroxidation of polyunsaturated fatty acids in “non‐proliferative” “proliferative” cells the large intestine, Sprague‐Dawley rats were fed diets providing a polyunsaturated‐to‐saturated acid ratio 1.2 or 0.3 at high low level intake for 25‐day period. Cell populations isolated effect on content peroxide levels was determined. Neither nor diet influenced total cholesterol, phospholipids, percentage phospholipid...