A5048531551- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Musculoskeletal pain and rehabilitation
- Spine and Intervertebral Disc Pathology
- Immunodeficiency and Autoimmune Disorders
- Circular RNAs in diseases
- Lymphoma Diagnosis and Treatment
- Family and Patient Care in Intensive Care Units
- Anesthesia and Pain Management
- Scoliosis diagnosis and treatment
- COVID-19 Impact on Reproduction
- Semiconductor materials and devices
- MicroRNA in disease regulation
- Diabetes and associated disorders
- Kawasaki Disease and Coronary Complications
- COVID-19 and healthcare impacts
- Silicon Carbide Semiconductor Technologies
- Socioeconomic Development in Asia
- Immune Response and Inflammation
- GaN-based semiconductor devices and materials
- Child and Adolescent Health
- Urticaria and Related Conditions
- Adolescent and Pediatric Healthcare
Singapore General Hospital
2022-2023
Evelina London Children's Healthcare
2021
Temple Street Children's University Hospital
2019
National University Cancer Institute, Singapore
2016
National University of Singapore
2000-2013
Institute of Molecular and Cell Biology
2001-2005
The University of Sydney
2000
Engagement of the B cell receptor (BCR) leads to activation tyrosine kinases and other signaling molecules that ultimately determine type magnitude lymphocyte's cellular response. The adaptor protein BLNK/SLP-65 plays a pivotal role in BCR signal transduction by coupling Syk downstream elements such as Grb2, phospholipase C-gamma, Vav Nck. We have generated BLNK(-/-) mice physiological this development activation. exhibit an incomplete block with severe inhibition pro-B pre-B...
B lymphocytes lacking the adaptor protein cell linker (BLNK) do not proliferate in response to antigen receptor (BCR) engagement. We demonstrate here that BCR-activated BLNK(-)/- cells fail enter cycle, and this is due their inability induce expression of cycle regulatory proteins such as cyclin D2 cyclin-dependent kinase 4. BCR-stimulated also up-regulate survival Bcl-x(L), which may be necessary for complete cycle. In addition, exhibit a high rate spontaneous apoptosis culture. Examination...
CD5(+) B (or B-1) cells are the normal precursors of cell chronic lymphocytic leukemia. They differ from conventional (B-2) with respect to their phenotype and mitogenic responses often secretors natural polyreactive antibodies in serum. The origin B-1 remains controversial, relationship between autoreactive is unclear. Here, we compare signaling pathways that activated by engagement antigen receptor (BCR) B-2 cells. Stimulation BCR leads induced activation three major classes...
The ubiquitously expressed transmembrane adaptor Csk-binding protein (Cbp) recruits Csk to lipid rafts, where the latter exerts its negative regulatory effect on Src family of tyrosine kinases. We have inactivated Cbp in mouse germ line. In contrast gene inactivation, which leads embryonic lethality and impaired T-cell development, Cbp-deficient mice were viable exhibited normal development but with an increased thymocyte population. absence Cbp, amount that localizes rafts was greatly...
Summary Acute lymphoblastic leukaemia ( ALL ) is the most common paediatric malignancy. Although 90% of patients are now long‐term survivors, remaining 10% have poor outcome predominantly due to drug resistance. In this study, we carried out genome‐wide micro RNA (mi microarray analysis on diagnostic bone marrow samples determine mi expression profiles associated with in . A reduced MIR 335 was identified as significant abnormality outcome. It well known that glucocorticoid GC resistance one...
Objectives Patients from ethnic minority groups and key workers are over-represented among adults hospitalised or dying COVID-19. In this population-based retrospective cohort, we describe the association of ethnicity, socioeconomic family worker status with incidence severity Paediatric Inflammatory Multisystem Syndrome Temporally associated SARS-CoV-2 (PIMS-TS). Setting Evelina London Children’s Hospital (ELCH), tertiary paediatric hospital for South Thames Retrieval Service (STRS) region....
Retrospective longitudinal study.To identify the preoperative factors associated with postoperative lumbar fusion recovery in back or leg pain, self-reported walking time, and gait speed over a 6-month period.The demand for surgeries has significantly increased years. Yet, some patients report persistent postsurgical pain poor functional outcomes. Unfortunately, risk are not well understood.The study analyzed 232 subjects mono- bisegmental surgery who underwent standardized assessment...
Psychological distress post lumbar spine surgery is associated with poorer outcomes. There a scarcity of studies devoted to analyzing the risk factors psychological in patients who have undergone fusion surgery. The purpose this study was (1) describe time course and severity using STarT Back Tool (SBT) (2) determine demographic clinical predictors SBT score surgery.This retrospective longitudinal analyzed 227 subjects 1- 2-level underwent standardized assessment preoperatively at 4 12 weeks...
<h3>Aims</h3> To determine parental satisfaction of a consultation with junior doctor in paediatric hospital, reference to the affective aspects medical council's domains good professional practice. <h3>Methods</h3> Administering five-point Likert scale questionnaire (1= strongly disagree, 5= agree) sample parents patients' following once-off doctor. The comprised five questions which examined doctors perceived; empathy, professionalism communication, confidence and parent's overall...
Previously, we showed that the Id_on vs. log Id_off plot can be used to characterize silicon-based enhancement-mode MOS transistors for both p-channel and n-channel [1]. AlGaN/GaN high electron mobility (HEMTs) have attracted world-wide interest microwave power transistor applications. There are two kinds of HEMTs: depletion-mode HEMTs. In general, HEMTs more common. For devices with source at 0 V, even though gate voltage may close zero, leakage current increases increase drain significant...