A5031308930- Stroke Rehabilitation and Recovery
- Cerebral Palsy and Movement Disorders
- Prosthetics and Rehabilitation Robotics
- Muscle activation and electromyography studies
- Advanced Machining and Optimization Techniques
- Vibration Control and Rheological Fluids
- Microbial Metabolic Engineering and Bioproduction
- Advanced machining processes and optimization
- Advanced Surface Polishing Techniques
- Biofuel production and bioconversion
- Innovative Teaching and Learning Methods
- Anatomy and Medical Technology
- Myofascial pain diagnosis and treatment
- Photorefractive and Nonlinear Optics
- Plant biochemistry and biosynthesis
- Materials Engineering and Processing
- Psychosomatic Disorders and Their Treatments
- Orthopedic Surgery and Rehabilitation
- Enzyme Structure and Function
- Botulinum Toxin and Related Neurological Disorders
- Microbial Natural Products and Biosynthesis
- Pain Management and Placebo Effect
- Recycling and utilization of industrial and municipal waste in materials production
- Spinal Dysraphism and Malformations
- Metallurgy and Material Science
Harvard University
2018-2024
John Wiley & Sons (Germany)
2023
Moss Landing Marine Laboratories
2023
Hudson Institute
2023
New York Academy of Sciences
2023
University of Michigan
2018
Robotics Research (United States)
2018
Shanghai Jinyuan Senior High School
2016
Institute of Biological Chemistry, Academia Sinica
2010-2015
National Taiwan University
2006-2014
Objective: Individuals with neurological damage (e.g., stroke or cerebral palsy) often experience a significant loss of arm function. Robotic devices that address muscle strength deficits in task-specific manner can assist the recovery function; however, current are typically large, bulky, and expensive to be routinely used clinic at home. This study sought this issue by developing portable planar passive rehabilitation robot, PaRRo. Methods: We designed PaRRo mechanical layout incorporated...
We expressed an active form of CtCel5E (a bifunctional cellulase/xylanase from Clostridium thermocellum), performed biochemical characterization, and determined its apo- ligand-bound crystal structures. From the structures, Asn-93, His-168, His-169, Asn-208, Trp-347, Asn-349 were shown to provide hydrogen-bonding/hydrophobic interactions with both ligands. Compared structures TmCel5A, a cellulase/mannanase homolog Thermotoga maritima, flexible loop region in is key for discriminating...
Abstract Chronic impairment in the paretic ankle following stroke often requires that individuals use compensatory patterns such as asymmetric propulsion to achieve effective walking speeds needed for community engagement. Ankle exosuit assistance can provide biomechanical benefit lab, but environments inherently limit amount of practice available. Community studies without exosuits massed and speed are limited their ability assist proper mechanics. In this study, we combined positive...
Caspase-3 downregulation (CASP3/DR) in tumors frequently confers resistance to cancer therapy and is significantly correlated with a poor prognosis patients. Because CASP3/DR cells rely heavily on the activity of caspase-7 (CASP7) initiate apoptosis, inhibition activated CASP7 (p19/p12-CASP7) by X-linked inhibitor apoptosis protein (XIAP) potential mechanism which prevented those cells. Here, we identify pocket surrounding Cys246 residue p19/p12-CASP7 as target for development...
Spinal dysraphism is a common birth defect that causes different kinds of secondary impairments, including joint deformities, reduced mobility, and bowel/bladder dysfunction. Due to the diversity in terminology, cultural/ethnic differences, medical policies, prior study results cannot be generalized all populations. Therefore, we performed this define characteristics patients Taiwan with spinal dysraphism.Patients diagnosed myelomeningocele or lipomyelomeningocele were identified from...
Laparoscopic surgery has to be operated with an assistant during surgery, which requires training and high cooperation work between the surgeon assistants. The objective of this study is develop a laparoscopic system providing intuitive maneuverability. We Robotic Flexible Laparoscope System (RFLS) compliance effect including adaptive impedance velocity control assist in surgery. controlled by surgeon's head movements, so that can use his/her hands manipulate instruments while maneuvering...
Abstract Background During inpatient rehabilitation, physical therapists (PTs) often need to manually advance patients’ limbs, adding burden PTs and impacting gait retraining quality. Different electromechanical devices alleviate this by assisting a patient’s limb advancement supporting their body weight. However, they are less ideal for neuromuscular engagement when patients no longer weight support but continue require assistance with as recover. The objective of study was determine the...
Suspending powder in dielectric fluid of EDM (electrical discharge machining) has been developed to improve the quality machined surface recently. The used powders are usually Al, Cu, Cr and so on metal because conductive particle can increase spark gap roughness surface. Semi-conductive powder, Si is also utilized for sake increasing machining speed. This paper presents a new tryout suspend polymer particles EDM. Experimental results show that process with suspending still be carried out...
Both Cr:LiCAF and Cr:LiSAF solid state lasers were developed by Payne et al. As transition-metal vibronic the exhibit broad emission spectra, long lifetime of upper laser levels, low nonlinear refractive indices, thermal lensing, excited absorption that make both them unique sources for tunable or short pulse lasers. In previous work we had experimentally demonstrated Cr:YSO could as a saturable absorber Q switch near 780 nm, i.e., peak its tuning range. this work, theoretically investigate...
Electrical discharge machining (EDM) is an excellent technology to die and mold, but it uneasy obtain mirror-like surface. Powder-Mixed dielectric electrical (PMD-EDM) the innovative of EDM process, which can improve quality machined surface applied in finish now. The powder usually hard particles, such as Al, Cu, Cr Si PMD-EDM. This paper presents a new research PMD-EDM with suspending soft particles abrasive grits fluid, especially focus on roughness. Experimental result shows process...
Previously we showed that yeast geranylgeranyl diphosphate synthase (GGPPS) becomes an inactive monomer when the first N-terminal helix involved in dimerization is deleted. This raises questions regarding why required for GGPPS activity and which amino acids dimer interface are essential dimerization-mediated activity. According to crystal structure, three (N101, N104, Y105) located F of one subunit near active site other subunit. As presented here, these residues were replaced individually...
With the development of Web technology, a number collaborative computer simulations are designed to support problem solving activities. However, studies show that some students often failed collaboratively solve with simulation. Little research has so far been done explore factors why problems The study activity simulation and attempted identify key successful learning task by analyzing students’ perceptions on solving. implication indicated that, simulation, communication, coordination,...
This paper presents the use of vibration measurement in conjunction with spectrum signal analysis to investigate phenomena and dynamic response absorber system frame rigid axle a vehicle body under real road-driving conditions. Ford 1.6L sedan was selected as carry out experiments different driving speeds. B&K PULSE analyzer used detect induced from motion. The acquired on-line signals are then processed through Fast Fourier Transform using power density, cepstrum method, overall...
The slag from steel plants or incinerators was tried to be recycled and reused as foam materials through plasma arc melting. study intended investigate the making of with laboratory melting facilities. investigated consisted different mixtures Al2O3、SiO2 、FetO、CaO Na2O, fluxes that were necessary examine capability pore-formation in solidified ingots. It has been found could obtained proper compositions conditions heating. dimensions distributions pores studied correlated temperatures slag....