A5020720543- Luminescence and Fluorescent Materials
- Organic Light-Emitting Diodes Research
- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Organic Electronics and Photovoltaics
- X-ray Diffraction in Crystallography
- Advanced Fluorescence Microscopy Techniques
- Crystallization and Solubility Studies
- Molecular Sensors and Ion Detection
- Photochemistry and Electron Transfer Studies
- Spectroscopy and Quantum Chemical Studies
- Analytical Chemistry and Sensors
- Advanced biosensing and bioanalysis techniques
- Photoreceptor and optogenetics research
- Porphyrin and Phthalocyanine Chemistry
- Perovskite Materials and Applications
- Cellular transport and secretion
- Phytochemistry and biological activities of Ficus species
- Ocular Infections and Treatments
- Time Series Analysis and Forecasting
- Radical Photochemical Reactions
- Conducting polymers and applications
- Data Visualization and Analytics
- Advanced Biosensing Techniques and Applications
- Axial and Atropisomeric Chirality Synthesis
Singapore University of Technology and Design
2024-2025
East China Normal University
2021-2024
Southwest Forestry University
2021
State Forestry and Grassland Administration
2021
Shandong Normal University
2019
Clean Energy (United States)
2019
Weifang University
2018
Near-infrared (NIR) fluorophores absorbing maximally in the region beyond 800 nm, i.e., deep-NIR spectral region, are actively sought for biomedical applications. Ideal dyes bright, nontoxic, photostable, biocompatible, and easily derivatized to introduce functionalities (e.g., bioconjugation or aqueous solubility). The rational design of such remains a major challenge. Silicon-substituted rhodamines have been successful bioimaging applications red region. longer-wavelength...
Photodynamic (PDT) and photothermal therapies (PTT) are emerging treatments for tumour ablation. Organic dyes such as porphyrin, chlorin, phthalocyanine, boron-dipyrromethene cyanine the clinically or preclinically used photosensitizer agents. Development of structurally diverse near-infrared with long absorption wavelength is great significance PDT PTT. Herein, we report a novel dye ML880 naphthalimide modified skeleton. The introduction moiety results in stronger electron delocalization...
Near-infrared-II (NIR-II) dyes could be encapsulated by either exogenous or endogenous albumin to form stable complexes for deep tissue bioimaging.However, we still lack a complete understanding of the interaction mechanism dye@albumin complex.Studying this principle is essential guide efficient dye synthesis and develop NIR-II probes with improved brightness, photostability, etc. Methods: Here, screen test optical chemical properties fluorophores, systematically investigate binding sites...
The emergence of multidrug resistant (MDR) pathogens and the scarcity new potent antibiotics antifungals are one biggest threats to human health. Antimicrobial photodynamic therapy (aPDT) combines light photosensitizers kill drug-resistant pathogens; however, there limited materials that can effectively ablate different classes infective pathogens. In present work, a class benzodiazole-paired is designed as highly PDT agents with broad-spectrum antimicrobial activity upon illumination...
Abstract Advancing photothermal therapy hinges on developing PTAs with robust in vivo delivery and therapeutic efficacy. However, effective molecular design approaches for high‐performance remain lacking. Herein a strategic of dimeric heptamethine cyanine (Cy7) molecules is presented, covalently linked via ortho / meta para ‐phenyldithiol. These designs facilitate spontaneous nanoparticle assembly water, attributed to efficient intermolecular aggregation, enhancing delivery. Additionally,...
Abstract Fluorescent imaging and biosensing in the near‐infrared‐II (NIR‐II) window holds great promise for non‐invasive, radiation‐free, rapid‐response clinical diagnosis. However, it's still challenging to develop bright NIR‐II fluorophores. In this study, we report a new strategy enhance brightness of aggregation‐induced emission (AIE) fluorophores through intramolecular electrostatic locking. By introducing sulfur atoms into side chains thiophene bridge TSEH molecule, molecular motion...
Fluorescent emitters with long exciton lifetime and high luminescence efficiency show promising application in organic light emitting diodes (OLEDs), especially those an aggregation induced emission (AIE) feature.
Abstract Fluorescent imaging and biosensing in the near‐infrared‐II (NIR‐II) window holds great promise for non‐invasive, radiation‐free, rapid‐response clinical diagnosis. However, it's still challenging to develop bright NIR‐II fluorophores. In this study, we report a new strategy enhance brightness of aggregation‐induced emission (AIE) fluorophores through intramolecular electrostatic locking. By introducing sulfur atoms into side chains thiophene bridge TSEH molecule, molecular motion...
Excited-state intramolecular proton transfer (ESIPT) and thermally activated delayed fluorescence (TADF) mechanisms in solid phase is revealed theoretically.
User interests manifest a dynamic pattern within the course of day, e.g., user usually favors soft music at 8 a.m. but may turn to ambient 10 p.m. To model in hour embedding is widely used traditional daily-trained industrial recommendation systems. However, its discreteness can cause periodical online patterns and instability recent streaming Recently, Interest Clock has achieved remarkable performance Nevertheless, it models users' coarse-grained manner, merely encoding discrete 24 hours...
Abstract Lysosomal morphology and pH dynamics are key indicators of lysosomal function, making long‐term single‐molecule localization microscopy (SMLM) imaging a promising tool for functional diagnostics. However, phototoxicity often compromises reliability. Here, we develop Aze‐HMSiR , spontaneously blinking silicon rhodamine probe with near‐infrared excitation, enabling low‐phototoxicity, (50 min) SMLM dynamics. This provides super‐resolution insights into distribution, size, lumen pH,...
Lysosomal morphology and pH dynamics are closely linked to lysosome functions, making long‐term single‐molecule localization microscopy (SMLM) imaging of whole‐cell lysosomes a potential indicator for functional diagnostics. However, the phototoxicity probes in SMLM often compromises reliability observed lysosomal dynamics. Here, we developed Aze‐HMSiR, spontaneously blinking silicon rhodamine probe with near‐infrared excitation, enabling low phototoxicity, morphology, up 50 minutes. This...
The quantum nature of the typically ignored but important NIR-II emission tail and fluorescence enhancement mechanism for cyanine–protein assemblies have been revealed from a multiscale computational investigation.
Thermally activated delayed fluorescence (TADF) molecules with dual emission have great potential for use as single emitters in white organic light-emitting diodes (WOLEDs). In this paper, the mechanisms of PTZ-TTR and PTZ-Ph-TTR blue-orange are studied systematically. The near-planar near-orthogonal conformations responsible blue orange emission, respectively. For PTZ-TTR, conformation is only generated by transformation from conformation, while can be both excitation transformation. This...
Multicolor luminescent materials with tunable properties hold great promise for a wide range of applications in science. Unfortunately, the conventional approach to achieving multicolor emissions by blending multiple types fluorophores is hindered limitations, notably, spectral instability, aggregation-caused quenching, and energy transfer. The pursuit from single type fluorophore solid state has, until now, remained formidable challenge. In this study, we have introduced N,N′-diphenyl...
Schematic diagram of ultrafast energy transfer from tyrosine to tryptophan in model peptides (WY, WPY, WP2Y, WP3Y). With the increase peptide chain length, lifetime first decreases and then increases.
A precursor, C21H29NO8 (A1) was prepared by reactions of 1,1-dimethoxy-N,N-dimethylmethanamine and 1,5-dioxaspiro[5.5]undecane-2,4-dione. The new N-containing heterocyclic compound, C19H19NO4 (B1) obtained adding A1 into ethanol solution o-toluidine. crystal structure determination two compounds were both found to belong the triclinic P-1 space group. precursor includes one (C2H8N)+ cation (C19H21O8)− anion, which constituted a chained N–H···O intra- intermolecular interactions. title...
Small molecules that are capable of toggling between multiple and definite conformational states under external stimuli have great potential for use in molecular switches or sensors. However, currently developed regulation approaches these switchable mostly involve covalent bond-breaking/reforming processes, thereby inevitably producing byproducts causing fatigue accumulation. Herein, we report a simple but successful model whose conformation can be precisely manipulated stretched folded...
Abietic acid and its derivatives have broadly been used in fine chemicals are renewable resources. Its inherent chiral rigid tricyclic phenanthrene skeleton is unique. utilities asymmetric catalysis remain to be explored. A series new amide-type quaternary ammoniums bearing dehydroabietylamine were designed, prepared by two convenient steps. Acylation of with bromoacetyl chloride afforded amide holding group higher yields using triethyl amine as base. Subsequent quaternization reaction gave...
Abstract Merocyanine dyes are of great interest amongst researchers due to their nonlinear optical (NLO) properties and solvatochromism. Molecular structure these constitutes conjugated pathway between the donor acceptor substituents, with lowest energy transition $$\mathrm \pi$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>π</mml:mi> </mml:math> – * character. To rationalize design deduce structure-property relationship, it is eminent unravel excited state dynamics in...