A Constantinescu

ORCID: 0009-0008-0524-609X
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Research Areas
  • Thyroid Disorders and Treatments
  • Medical Imaging Techniques and Applications
  • Pituitary Gland Disorders and Treatments
  • Radiopharmaceutical Chemistry and Applications
  • Glioma Diagnosis and Treatment
  • Adipose Tissue and Metabolism
  • Mechanical Circulatory Support Devices
  • Ophthalmology and Eye Disorders
  • Hemoglobin structure and function
  • Thyroid Cancer Diagnosis and Treatment
  • Brain Metastases and Treatment
  • Radiation Detection and Scintillator Technologies
  • Advanced MRI Techniques and Applications
  • Cardiac and Coronary Surgery Techniques
  • Meningioma and schwannoma management
  • Cerebral Venous Sinus Thrombosis
  • Medical Imaging and Pathology Studies
  • Cancer, Hypoxia, and Metabolism
  • Nuclear Physics and Applications
  • Antioxidant Activity and Oxidative Stress
  • Orthopaedic implants and arthroplasty
  • Organ Transplantation Techniques and Outcomes
  • Teratomas and Epidermoid Cysts
  • Pancreatic and Hepatic Oncology Research
  • Urologic and reproductive health conditions

Carol Davila University of Medicine and Pharmacy
2024

Universitatea Națională de Știință și Tehnologie Politehnica București
2024

Clinical Emergency Hospital Bucharest
1968-2024

GSI Helmholtz Centre for Heavy Ion Research
2011

The University of Texas Southwestern Medical Center
1993-2006

Southwestern Medical Center
1991-2006

Johns Hopkins University
1993

Johns Hopkins Medicine
1993

University of Pennsylvania
1988

United States Marine Corps
1968

M Schlissel, A Constantinescu, T Morrow, Baxter, and Peng Department of Medicine, Johns Hopkins University School Baltimore, Maryland 21205.

10.1101/gad.7.12b.2520 article EN Genes & Development 1993-12-01

Abstract The goal of the current study was to determine high-resolution frequencies HLA-DRB1 alleles among analyzed Romanian cohort healthy stem cell donors. Using Next Generation Sequencing (NGS), we estimated class II allele a 6-digit resolution through HLA typing in individuals. for genotyping included 420 willing donors from National Registry Voluntary Hematopoietic Stem Cell Donors (RNDVCSH). In 2020 and 2021, peripheral blood samples were collected transported Fundeni Clinical...

10.2478/bjmg-2024-0009 article EN Balkan Journal of Medical Genetics 2024-06-01

The role of zinc in beef heart cytochrome c oxidase has been studied by using x-ray absorption spectroscopy, depletion and secondary structure predictions subunits oxidase. stoichiometry determined 35 different preparations found to be one-half copper (Cu:Zu = 2:1). Zinc is tightly bound this enzyme cannot removed dialysis against EDTA. However, could partially (up 50%) depleted treating the with either dipicolinic acid or trypsin digestion. This partial does not change O2 uptake rate. X-ray...

10.1016/s0021-9258(18)37760-3 article EN cc-by Journal of Biological Chemistry 1988-09-01

Fractures of the proximal humerus are a frequent ailment in senior population. One concern with such case that presented our emergency room was risk varus collapse following open reduction and internal fixation (ORIF) patient marked calcar comminution. The surgical method used this NEER four-part fracture medial column instability proved effective terms good surgery outcome, satisfaction, range motion, low or no pain at post-surgical follow-ups. ORIF locking plate fibular strut graft to be...

10.7759/cureus.53164 article EN Cureus 2024-01-29

We have produced a chimeric antibody (Ab) in which metallothionein, well-characterized biological chelator of metals, was genetically fused to the F(ab') domain S107 Ab heavy chain. Coexpression with light chain that conveys specificity for synthetic antigen phosphocholine achieved plasmacytoma cells. Metal- and antigen-binding domains Ab-metallothionein hybrid function normal avidity specificity. can be efficiently loaded 99mTc used specifically bind phosphocholine-haptenated cells vitro or...

10.1073/pnas.89.20.9749 article EN Proceedings of the National Academy of Sciences 1992-10-15

A Small Animal Imager (SAI) for PET has been designed, built, tested in phantoms, and applied to investigations mice rats. The device uses principles based on gamma-ray induced scintillation crossed fiber optic detectors connected Position Sensitive Photomultiplier Tubes (PSPMT). Each detector consists of an epoxied stack 28 layers 135 round 1 mm BCF-10 scintillating plastic fibers. overlap region forms a 13.5times13.5times2.8 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML"...

10.1109/tns.2006.876000 article EN IEEE Transactions on Nuclear Science 2006-10-01

We employed gamma scintigraphy to quantify the transient accumulations of platelets in pump-oxygenator systems cardiopulmonary bypass (CPB). A flat sheet microporous polypropylene membrane oxygenator (Cobe Duo) was employed, with and without siloxane/caprolactone oligomer coating (SMA) (n = 8 each). The effect nitric oxide gas infusion on platelet deposition also evaluated for uncoated Cobe Duo system 10 Scintigraphic images radiolabelled cells were obtained converted numbers all platelets,...

10.1163/156856299x00153 article EN Journal of Biomaterials Science Polymer Edition 1999-01-01

Bhujle, R.; Li, J.; Shastri, P.; Gaffke, Clift, Ye, Y.; Chao, Constantinescu, A.; Kulkarni, Jessen, M.; Eberhart, R. Author Information

10.1097/00002480-199703000-00129 article EN ASAIO Journal 1997-03-01

Despite progresses made in oncology, pancreatic adenocarcinoma has a grim prognosis and commonly presents with rapidly advancing jaundice which requires endoscopic treatment. AIM Our objective was to show the perspective of high ERCP volume dedicated Center on stenting for malignant biliary obstruction consecutive cancer. METHODS We conducted retrospective study, between October 2017 2020, enrolled hospitalized patients within Gastroenterology Department Clinical Emergency Hospital...

10.12865/chsj.46.04.01 article EN Craiova medicală 2020-01-01

Rajasubramanian, S.; Shastri, P.; Constantinescu, A.; Nelson, K.; Kulkarni, Jessen, M.; Eberhart, R. Author Information

10.1097/00002480-199703000-00051 article EN ASAIO Journal 1997-03-01

An electronic collimation technique is developed which utilizes the chi-square goodness-of-fit measure to filter scattered gammas incident upon a medical imaging detector. In this data mining technique, Compton kinematic expressions are used as fitting templates for measured energy-deposition involving multiple-interaction scatter sequences. Fit optimization conducted using Davidon variable metric minimization algorithm simultaneously determine best-fit gamma angles and their associated...

10.1088/0031-9155/43/10/020 article EN Physics in Medicine and Biology 1998-10-01

The union of tibial fractures often raises concerns. In one such case, a 62-year-old female patient presented in our Emergency Room (ER) with comminuted metaphyseal fracture resulting from traffic accident. underwent three surgical procedures the following two years. first intervention was open reduction internal fixation (ORIF) plate and screws. second intervention, which took place months after surgery, addressed delay through implant removal closed (CRIF) an antegrade intramedullary nail....

10.7759/cureus.58831 article EN Cureus 2024-04-23

The mental health of social media users has started more and to be put at risk by harmful, hateful, offensive content. In this paper, we propose \textsc{StopHC}, a harmful content detection mitigation architecture for platforms. Our aim with \textsc{StopHC} is create secure online environments. solution contains two modules, one that employs deep neural network detection, uses immunization algorithm block toxic nodes stop the spread efficacy our demonstrated experiments conducted on...

10.48550/arxiv.2411.06138 preprint EN arXiv (Cornell University) 2024-11-09

The widely applied single-interaction analytic expression characterizing the energy resolution component of angular precision for an electronically collimated point source is extended to include multiple-interaction Compton scatter sequences as well terminated by photoelectric absorption. formulation developed using statistical variance mean components comprising composite, multivariate estimators. It demonstrated that enhanced in incident interaction angle attained when use made information...

10.1088/0031-9155/43/10/021 article EN Physics in Medicine and Biology 1998-10-01

Sly, M.; Prager, Li, J.; Harris, F.; Shastri, P.; Chao, R.; Kulkarni, Constantinescu, A.; Jessen, Eberhart, R. Author Information

10.1097/00002480-199603000-00073 article EN ASAIO Journal 1996-03-01
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