A5070880431- Spine and Intervertebral Disc Pathology
- Cervical and Thoracic Myelopathy
- Spinal Fractures and Fixation Techniques
- Orthopaedic implants and arthroplasty
- Musculoskeletal pain and rehabilitation
- Medical Imaging and Analysis
- Spinal Hematomas and Complications
- Anesthesia and Pain Management
- Meningioma and schwannoma management
- Head and Neck Surgical Oncology
- Bone Tissue Engineering Materials
- Facial Nerve Paralysis Treatment and Research
- Total Knee Arthroplasty Outcomes
- Scoliosis diagnosis and treatment
- Ergonomics and Musculoskeletal Disorders
- Health and Wellbeing Research
- Bone Tumor Diagnosis and Treatments
- SARS-CoV-2 detection and testing
- COVID-19 Clinical Research Studies
- Neurological and metabolic disorders
- Cerebral Venous Sinus Thrombosis
- Cardiac, Anesthesia and Surgical Outcomes
- Clinical practice guidelines implementation
- Cerebrospinal fluid and hydrocephalus
- Long-Term Effects of COVID-19
Cedars-Sinai Medical Center
2006-2025
Beverly Hills Cancer Center
2015-2022
National Center for Spinal Disorders
2022
University of California, Los Angeles
1989-2020
Olive View-UCLA Medical Center
2020
Century Health
2004-2019
University of California, San Diego
2018
Doctors Hospital
2010
Exponent (United States)
2010
Doctors Hospital
2008
Objective To test the safety and efficacy of a bioartificial liver support system in patients with severe acute failure. Summary Background Data authors developed using porcine hepatocytes. The was tested vitro shown to have differentiated functions (cytochrome P450 activity, synthesis liver-specific proteins, bilirubin synthesis, conjugation). When vivo experimental animals failure, it gave substantial metabolic hemodynamic support. Methods Seven failure received double lumen catheter...
Object. The choice of approach for surgical removal large acoustic neuromas is still controversial. authors reviewed the results in a series patients who underwent tumors via translabyrinthine approach. Methods. conducted database analysis 190 (89 men and 101 women) with 3 cm or greater size. mean age these was 46.1 ± 15.6 years. One hundred seventy-eight primary 12 surgery residual tumor. Total tumor accomplished 183 cases (96.3%). adherent to facial nerve some degree 64% cases, but...
OBJECTIVE The authors compared the efficacy and safety of arthroplasty using Prestige LP cervical disc with those anterior discectomy fusion (ACDF) for treatment degenerative disease (DDD) at 2 adjacent levels. METHODS Patients from 30 investigational sites were randomized to 1 groups: patients (209) underwent a artificial disc, control (188) ACDF cortical ring allograft plate. evaluated preoperatively, intraoperatively, 1.5, 3, 6, 12, 24 months postoperatively. Efficacy outcomes measured...
OBJECTIVE The aim of this study was to assess long-term clinical safety and effectiveness in patients undergoing anterior cervical surgery using the Prestige LP artificial disc replacement (ADR) prosthesis treat degenerative spine disease at 2 adjacent levels compared with discectomy fusion (ACDF). METHODS A prospective, randomized, controlled, multicenter FDA-approved trial conducted 30 US centers, comparing low-profile titanium ceramic composite-based ADR (n = 209) ACDF 188). Clinical...
The authors assessed the 10-year clinical safety and effectiveness of cervical disc arthroplasty (CDA) to treat degenerative spine disease at 2 adjacent levels compared anterior discectomy fusion (ACDF).
The concept of semi-rigid fixation (SRF) has driven the development spinal implants that utilize nonmetallic materials and novel rod geometries in an effort to promote fusion via a balance stability, intra- inter-level load sharing, durability. purpose this study was characterize mechanical biomechanical properties pedicle screw-based polyetheretherketone (PEEK) SRF system for lumbar spine compare its kinematic, structural, durability performance profile against traditional systems....
Background The pathophysiology and mechanisms driving the generation of unintended pain after total disc replacement (TDR) remain unexplored. Ultrahigh-molecular-weight polyethylene (UHMWPE) wear debris from TDRs is known to induce inflammation, which may result in pain. Questions/purposes purpose this study was determine whether (1) periprosthetic UHMWPE induces immune responses that lead production tumor necrosis factor-α (TNFα) interleukin (IL)-1β, vascularization factors, vascular...
In Brief Study Design. A large case series of anterior revision surgery in patients who had complications following lumbar total disc replacement with the CHARITÉ artificial disc. Objectives. To analyze and discuss etiology implant-related to present a strategy that can be applied intervertebral prostheses cases where is necessary. Summary Background Data. This report represents largest single-site, consecutive reported literature arthroplasty. Methods. 18 are included this study. All...
Various designs of total disc replacement (TDR) devices have been compared to anterior cervical discectomy and fusion (ACDF) with favorable outcomes in FDA-approved investigational device exemption trials. The design M6-C a compressible viscoelastic nuclear core an annular structure is substantially different than prior has previously demonstrated kinematics clinical small case series.To evaluate the safety effectiveness novel artificial ACDF for subjects single-level degenerative...
The goal of this study was to assess the efficacy bioabsorbable interbody spacers in cervical spine fusion.The authors report on a prospective examination 20 patients with degenerative disc disease who underwent anterior fusion at 28 total levels. used Infuse bone graft (that is, recombinant human morphogenetic protein-2 applied an absorbable collagen sponge and contained within Cornerstone-HSR spacer. Multiple-level fusions were performed 30% these patients. At 3 months postfusion,...
In Brief Study Design. Retrospective retrieval analysis. Objective. To evaluate wear, deformation and biodegradation within retrieved polycarbonate urethane (PCU) components of Dynesys systems. Summary Background Data. The Dynamic Stabilization System (Zimmer Spine) consists pedicle screws (Ti alloy), spacers, a polyethylene-terephthalate cord. Methods. Seventeen (mean implantation: 2.5 years, range: 0.7–7.0 years) 2 exemplar implant systems were available. Reasons for revision persistent...
An aneurysmal bone cyst (ABC) in the paranasal sinuses is rare with only four previous cases having been described sphenoid and ethmoid sinuses. This report describes a case of an ABC involving as well upper nasal fossae. It currently believed that preexisting primary lesion, such fibrous dysplasia, initiates osseous arteriovenous fistula, which creates secondary reactive lesion bone, ABC. These lesions, are comprised multiple cysts containing liquid blood serous fluid, optimally studied by...
Object. To evaluate the effectiveness of recombinant human bone morphogenetic protein-2 (rhBMP-2) combined with a bioresorbable implant, authors conducted prospective study 43 patients degenerative lumbar disc disease who underwent transforaminal interbody fusion. Methods. The used Infuse graft, which consisted rhBMP-2 applied to an absorbable collagen sponge and contained within HYDROSORB Telamon implant perform Multilevel fusions were performed in 30% patients, for total 57 levels. At 6...
The frequency and complexity of spinal surgery performed in an ambulatory center (ASC) is increasing. However, safety efficacy data most procedures adapted to the ASC are sparse have focused on anterior cervical surgery. purpose this study was compare 90-day complication readmission rates lumbar spine or inpatient setting.We a retrospective comparative analysis 226 consecutive surgeries (283 levels treated) completed (n = 124) tertiary care hospital 102) over 3-year period. These included...
Study Design: Analysis of 2- and 7-year outcomes from a clinical trial comparing 2-level cervical disk arthroplasty (CDA) to anterior discectomy fusion (ACDF) in 287 patients with radiculopathy alone, 110 myelopathy alone or radiculopathy. Objective: To compare the long-term safety effectiveness CDA for versus Summary Background Data: is safe effective short term. Materials Methods: We analyzed Neck Disability Index (NDI), neck/arm pain, SF-36, neurological status, adverse events (AEs),...
Anterior cervical discectomy and fusion (ACDF) disc arthroplasty (CDA) have been used to treat degenerative disease at single as well multiple levels. This study compares the safety efficacy of 1-level versus 2-level CDA ACDF.In total, 545 397 patients with were studied in Food Drug Administration (FDA)-approved clinical trials, respectively: (n = 280 209), ACDF 265 188). Data from these studies compare 1- procedures: propensity score method was adjust for potential confounding effects,...