Hiroko Arai

ORCID: 0009-0008-0781-0731
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About
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Research Areas
  • Alkaloids: synthesis and pharmacology
  • Traditional and Medicinal Uses of Annonaceae
  • Chemical synthesis and alkaloids
  • Plant and Fungal Species Descriptions
  • Bioactive Natural Diterpenoids Research
  • Plant-based Medicinal Research
  • Berberine and alkaloids research
  • Malaria Research and Control
  • Urticaria and Related Conditions
  • Marine Sponges and Natural Products
  • Axial and Atropisomeric Chirality Synthesis
  • Chromatography in Natural Products
  • Chemical Reactions and Isotopes
  • Nitric Oxide and Endothelin Effects
  • Phytochemistry and biological activity of medicinal plants
  • Healthcare and Venom Research
  • Contact Dermatitis and Allergies
  • Microbial Natural Products and Biosynthesis
  • Analytical Chemistry and Chromatography
  • Glycosylation and Glycoproteins Research
  • Molecular Sensors and Ion Detection
  • Venomous Animal Envenomation and Studies
  • Synthetic Organic Chemistry Methods
  • Infant Nutrition and Health
  • Innovative Microfluidic and Catalytic Techniques Innovation

Toho University
2024

Hoshi University
2009-2014

University of Malaya
2010

Ebara (Japan)
2009

Airlangga University
2009

Kirin (Japan)
1998

Yokohama Minami Kyosai Hospital
1990

Tohoku University
1967

National Cancer Research Institute
1966

Tokyo Medical and Dental University
1964

10.1038/s41598-025-01634-7 article EN cc-by-nc-nd Scientific Reports 2025-05-16

Crude venom preparations obtained by drying the contents of paratid glands sea snakes, Laticauda semifasciata (Reinwardt) and laticaudata (Linnaeus), showed strong neurotoxic activity. One hundred pergram percent lethal dose to mice intramuscular injection was 0.5 μg. 0.3μg. per gram body weight mouse for L. laticaudata, respectively. The toxic component in non-dialyzable. It stable when dialyzed against saline, but inactivated water. completely heating at 100°C 15 minutes. treatment with...

10.1093/oxfordjournals.jbchem.a128035 article EN The Journal of Biochemistry 1964-12-01

Four new alkaloids, alstiphyllanines A−D (1−4), were isolated from Alstonia macrophylla, and their structures determined by MS 2D NMR analyses. Alkaloids 1−4 showed moderate antiplasmodial activity against Plasmodium falciparum vasorelaxant phenylephrine-induced contraction of rat aorta.

10.1021/np8007107 article EN Journal of Natural Products 2009-02-03

A phytochemical study on the bark of Neisosperma oppositifolia (Apocynaceae) yielded two new β-carboline indole alkaloids, oppositinines (1) and B (2), together with five known isoreserpiline, isocarapanaubine, vobasine, 10-methoxydihydrocorynantheol-N-oxide, ochropposinine oxindole. Structural elucidation 1 2 was performed using 2D NMR methods. Oppositinines (2) showed potent vasorelaxant effects rat aorta.

10.1248/cpb.58.1085 article EN Chemical and Pharmaceutical Bulletin 2010-01-01

A new diterpenoid alkaloid, sharwuphinine (1) was isolated from the aerial part of Delphinium sharwurense and structure possessing a lycoctonine-type C 19 -diterpenoid alkaloid with nitrone functionality elucidated by spectroscopic analysis.Sharwuphinine showed moderate vasorelaxant activity on rat aorta.Delphinium species have been employed in analgesic balms, sedatives, emetics, antihelminthics folk medicine. 1About twenty are distributed Xinjiang Uygur autonomous region, People's Republic...

10.3987/com-09-s(s)20 article EN Heterocycles 2009-10-26

The binding ratio of palmitic acid (PA) at the sn-2 position triacylglycerols in infant formulas is lower than that breast milk, resulting higher levels fecal PA. Even if increased to 40–50%, PA formula-fed infants remain those breast–fed infants. In Japan, with 50% or more bound (high milk) are commercially available; however, their effects on excretion have not been investigated. Therefore, this observational study aimed preliminarily evaluate whether feeding volume high milk significantly...

10.3390/nu16111558 article EN Nutrients 2024-05-21

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”

10.1002/chin.201007197 article EN ChemInform 2010-01-22

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”

10.1002/chin.201022174 article EN ChemInform 2010-05-12
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