A5065498524- Lung Cancer Treatments and Mutations
- HER2/EGFR in Cancer Research
- Biochemical and Molecular Research
- PI3K/AKT/mTOR signaling in cancer
- Genomics, phytochemicals, and oxidative stress
- Cancer-related gene regulation
- Magnetic properties of thin films
- Cancer therapeutics and mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Phytochemicals and Antioxidant Activities
- Cancer Genomics and Diagnostics
- Atomic and Subatomic Physics Research
- Nuclear Physics and Applications
- Cancer Mechanisms and Therapy
- Radiation Detection and Scintillator Technologies
- Quinazolinone synthesis and applications
- Magnetic Properties and Applications
- Chemical Reactions and Isotopes
- Retinoids in leukemia and cellular processes
- Tea Polyphenols and Effects
- melanin and skin pigmentation
- Chemical Synthesis and Analysis
- Antioxidant Activity and Oxidative Stress
- Hygrothermal properties of building materials
- Melanoma and MAPK Pathways
Taiho Pharmaceutical (Japan)
2018-2023
Tokyo-Kita Medical Center
2022-2023
Rady Children's Hospital-San Diego
2022
University of California, San Diego
2022
Okayama University
1993-2016
Otsuka (Japan)
2014
Niigata University
2012
Iwate Medical University
2012
Tohoku University
1997-2009
Fujifilm (Japan)
1993-2006
Activating mutations in the EGFR gene are important targets cancer therapy because they key drivers of non-small cell lung (NSCLC). Although almost all common mutations, such as exon 19 deletions and L858R point mutation 21, sensitive to EGFR-tyrosine kinase inhibitor (TKI) therapies, NSCLC driven by 20 insertion is associated with poor clinical outcomes due dose-limiting toxicity, demonstrating need for a novel therapy. TAS6417 that while sparing wild-type (WT) EGFR. In viability assays...
Abstract Despite the worldwide approval of three generations EGFR tyrosine kinase inhibitors (TKI) for advanced non–small cell lung cancers with mutations, no TKI a broad spectrum activity against all clinically relevant mutations is currently available. In this study, we sought to evaluate covalent mutation-specific TKI, TAS6417 (also named CLN-081), broadest level prevalence ≥1%. Lung cancer and genetically engineered lines, as well murine xenograft models were used efficacy other...
A very thin and smooth magnetic coating of metal particulate (MP) tape is made possible by the dual method. This MP consists a upper layer nonmagnetic underlayer composed fine (TiO/sub 2/) powder. The anticipated advantages decreasing thickness were observed. Hc, Hr, squareness increased as decreased. Thinning to thicknesses below 0.3 mu m reproduced output 1.5 dB achieved same value Hi-8 evaporated (ME) tape. loss moment density under conditions 60 degrees C 90% RH independent layer....
Carcinogenesis and cancer progression, driven by mutations in oncogenes tumor-suppressor genes, result biological differences between normal cells various cellular processes. Specific genes signaling molecules involved such processes may be potential therapeutic targets of agents that specifically interact with the key factors cells. Increased glucose uptake is fundamental to many solid tumors well associated increases glycolysis overexpression transporters (GLUTs) as GLUT1 GLUT3 at plasma...
A magnetic tape with a 65-nm-thick layer containing fine barium-ferrite particles was produced using an advanced precision coating process. Using giant magneto-resistive head on drum tester, signal-to-noise ratio of 23.5 dB achieved at linear density 200 kfci, indicating the feasibility approximately 7 Gb/in <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> recording
This paper reports the experimental results of developed barium ferrite tape, which shows feasibility 7 Gbits/inch <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> recording density.
Abstract Anaplastic lymphoma kinase (ALK) is an oncogenic receptor tyrosine that activated by gene amplification and mutation in neuroblastomas. ALK inhibitors can delay the progression of ALK-driven cancers, but are limited use owing to inhibitor resistance. Here, we show resistance neuroblastomas be attenuated combination treatment with a p53 activator. Either inhibition or activator induced cell cycle arrest, whereas apoptosis, prevented tumour relapse both vitro vivo. This shift toward...
(-)-Epigallocatechin-3-gallate (EGCG), the most abundant polyphenolic constituent in green tea, is known as a powerful antioxidant but concomitantly possesses prooxidant property. We investigated effect of EGCG on phloxine B (PhB)-induced photocytotoxicity human T lymphocytic leukemia Jurkat cells. significantly potentiated PhB-induced photocytotoxic effects, including inhibition cell proliferation, DNA fragmentation, and caspase-3 activity induction Catalase attenuated enhanced cytotoxicity...
Lanosterol synthase catalyzes the polycyclization reaction of (3S)-2,3-oxidosqualene (1) into tetracyclic lanosterol 2 by folding 1 in a chair-boat-chair-chair conformation. 27-Nor- and 29-noroxidosqaulenes (7 8, respectively) were incubated with this enzyme to investigate role methyl groups on for cascade. Compound 7 afforded two enzymatic products, namely, 30-norlanosterol (12) 26-normalabaricatriene (13; 12/13 9:1), which produced through normal conformation an atypical chair-chair-boat...
Preventing interbowel adhesions still remains a challenge. Peritoneal mesothelial damage can induce postoperative adhesions. Our study evaluated the effects of 3% trehalose solution on protection and adhesion prevention. Also, we compared this novel with Seprafilm regarding efficacy.Mesothelial was induced cultured human cell (Met-5A) rabbit cecum-serosal surface by air-drying for 60 min, applied. Cell integrity tested measuring lactate dehydrogenase, serosal-morphologic changes were...
Abstract The MAPK and PI3K pathways are involved in cancer growth survival; however, the clinical efficacy of single inhibitors each pathway is limited or transient owing to resistance mechanisms, such as feedback signaling and/or reexpression receptor-type tyrosine kinases (RTK). This study identified a potent novel kinase inhibitor, TAS0612, characterized its properties. We found that TAS0612 potent, orally available compound can inhibit p90RSK (RSK), AKT, p70S6K (S6K) agent showed strong...
An allergen-stimulating cytokine, interleukin-13 (IL-13), plays a significant role in allergic inflammation. Benzyl isothiocyanate (BITC), derived from several cruciferous vegetables, significantly suppressed the IL-13 expression calcium ionophore-stimulated human basophilic KU812 cells. Down-regulation of phosphorylated mitogen-activated protein kinases as well nuclear transcriptional factors might be involved underlying mechanism.
ABSTRACT Ascorbic acid (AsA) is known as an antioxidant but concomitantly possesses a pro‐oxidant property. Because the impact of AsA on photodynamic therapy response unclear, we investigated effect photocytotoxicity induced by phloxine B in human acute promyelocytic leukemia HL‐60 cells. synergistically enhanced B‐induced photocytotoxic effects, including inhibition cell proliferation, DNA ladder formation, and caspase‐3 activation, whereas itself showed no photocytotoxicity. also...
In the present study, we investigated anti-proliferative effects of four tea catechins: (-)-epicatechin (EC), (-)-epigallocatechin (EGC), gallate (ECg) and (EGCg) in human T lymphocytic leukemia Jurkat cells. Each catechin induced a significant cytotoxic effect on Combinations EGCg with other catechins additively potentiated anti-proliferation, extracellular hydrogen peroxide formation, c-Jun N-terminal kinase (JNK) activation interferon (IFN)-γ mRNA expression. Catalase partly but...
In the present study, we evaluated modifying behavior of simple phenolic compounds on sulfhydryl groups glutathione and proteins. The catechol-type polyphenols, including protocatechuic acid, but neither monophenols nor O-methylated catechol, can modify in a phenol oxidase-dependent manner. possible involvement polyphenol bioactivation enhancement skin inflammation was also suggested.
In the present study, we examined toxicity of benzyl ITC (BITC) and its urinary mercapturic acid metabolite (BITC-NAC), using a normal renal proximal tubular cell line, pig LLC-PK1. BITC increased death with an IC50 value about 7 μM, whereas cytotoxic effect BITC-NAC was five times weaker than that BITC. We observed significant necrosis compounds on LLC-PK1 cells oxidative stress. presence 5 mM glutathione (GSH), comparable to physiological levels, cytotoxicity as well significantly reduced....
Pre-treatment with α-tocopherol (α-Toc) potentiated cytotoxicity induction by benzyl isothiocyanate (BITC). Biochemical events related to apoptosis, such as DNA ladder formation and caspase-3 activation, were also enhanced α-Toc. These results suggest a significant role of the pathway in apoptosis regulated α-Toc combination.
Abstract By infrared absorption spectroscopy we have determined the orientation of backbone structure polyimide with alkyl side-chains in rubbed film. The was from dichroic ratio at normal incidence and incident angle dependence by IR active vibrations polarized along structure. We found that is oriented rubbing direction tilted up on average 23° surface. pretilt bulk liquid crystal (LC) contact this film 9.6°. inclination are much higher than those for without a side-chain reported our...
<p>Supplementary Figure 2. Pharmacodynamic marker inhibitions in the HCC70 tumor xenografts treated after repetitive doses of TAS0612. TAS0612, 60 mg/kg, was administered to tumor-bearing mice daily from Day 1 8 by oral gavage, and subcutaneously implanted tumors were dissected at 4 hour post-administration on 8. After sampling, immunoblot analysis performed detect pharmacodynamic inhibitions, signal feedback, apoptosis induction. Clear inhibition markers such as phospho-PRAS40,...