The totality of the societal and individual impact treatment-resistant depression (TRD) is unknown, as potential to prognosticate TRD. generalizability many observational studies on TRD limited.To estimate burden in a large population-wide cohort an area with universal health care by including data from both types (psychiatric nonpsychiatric) and, further, develop prognostic model for clinical use.This study, population-based assessed Stockholm MDD Cohort episodes major depressive disorder...

The most commonly reported diagnoses in primary care are useful to identify and meet health needs society. We estimated the rates of common total also by gender.This was a cross-sectional study including all 2.0 million inhabitants living Stockholm County, Sweden, on 1 January 2009. Data appointments made 2011 during 2009-11 were extracted from County Council data warehouse VAL (Vårdanalysdatabasen; regional warehouse). Primary analysed underlying population age. Appropriate specialist open...

Importance Major depressive disorder (MDD) is an important risk factor of suicidal behavior, but the added burden behavior and MDD on patient societal level, including all-cause mortality, not well studied. Also, contribution various prognostic factors for has been quantified in larger samples. Objective To describe clinical outcomes, patients with to explore associated management inform future research guidelines. Design, Setting, Participants This population-based cohort study used health...

ABSTRACT Objective The study aimed to estimate 5‐year recurrence rates of first‐episode major depressive disorder (MDD) and assess the impact adolescence on likelihood after first episode, compared adults. Methods A pre‐registered retrospective cohort that utilized epidemiological data from Stockholm MDD Cohort (1997–2018), including all individuals registered with a depression diagnosis in Region 2010 2018. This dataset combines longitudinal information primary secondary care, socioeconomic...

Combination lipid-lowering therapy (LLT) after myocardial infarction (MI) achieves lower low-density lipoprotein cholesterol (LDL-C) levels and better cardiovascular outcomes vs statin monotherapy. As a result, global guidelines recommend LDL-C but, paradoxically, advise treatment through stepwise approach. Yet the need for combination is inevitable as <20% of patients achieve goals with statins alone. Whether combining ezetimibe early late MI results in unknown. In this study, authors...

Since the beginning of Covid-19 pandemic, scientific community has explored determinants Covid 19 disease severity. However, majority studies are based on in-hospital patients with high risk collider- or selection bias. The present investigation details factors associated overall mortality, hospitalization and intensive care unit (ICU) admission in infections, complete population coverage high-resolution data patient characteristics comorbid conditions This population-based observational...

Heart failure guidelines have recently introduced a narrow category with mildly reduced left ventricular ejection fraction (LVEF) (heart fraction; LVEF 41%-49%) between the previous categories of ≤40%) and preserved ≥50%) fraction. Grouping continuous measurements into can be questioned if their variability is high.

Background Attention deficit hyperactivity disorder (ADHD) is associated with risk taking and negative health‐related outcomes across the lifespan. Due to delay in referral diagnostics, young females ADHD may not be identified, nor appropriately supported by adequate interventions. Methods A total of 85,330 individuals ADHD, all whom were residents Stockholm County between January 01, 2011, December 31, 2021, included as participants this population‐based, cross‐sectional cohort study....

Hyperkalaemia is a barrier to achieving optimal, guideline-directed treatment with renin-angiotensin-aldosterone system inhibitors (RAASis) in patients chronic kidney disease (CKD) and/or heart failure (HF). This study describes the association between hyperkalaemia-related RAASi reduction and number of hospitalized days CKD HF Sweden Japan.

Objective: To measure small-area variations in sales per capita of tumour necrosis factor (TNF) inhibitors.Methods: For 2000–2009, data on etanercept, infliximab, and adalimumab were retrieved from the Swedish National Corporation Pharmacies, which keeps drugs dispensed ambulatory care hospitals. As points reference, all drugs, non-biologic treatments for chronic inflammatory disorders (sulfasalazine, methotrexate, azathioprine), a biologic used different therapeutic area (trastuzumab)....

TNF inhibitors (TNFi) have been shown to reduce the need for surgery in Crohn's disease, but few studies examined their effect beyond first year of treatment.To conduct a register-based observational cohort study Sweden 2006-2014 investigate risk bowel resection naïve TNFi-treated disease patients and whether on TNFi ≥12 months are less likely undergo than discontinuing treatment before 12 months.We identified all individuals with through Swedish National Patient Register 1987-2014 evaluated...

To investigate if use of antibiotics was associated with bacterial complications following upper respiratory tract infections (URTIs).Ecological time-trend analysis and a prospective cohort study.Primary, outpatient specialist inpatient care in Stockholm County, Sweden. All analyses were based on administrative healthcare data consultations, diagnoses dispensed from January 2006 to 2016.Ecological analysis: 10-year trend the incidence URTIs, infections/complications antibiotic use....

Aims In patients with heart failure, treatment patterns in the last years of life have not been assessed at large scale. We aimed to assess whether failure up 5 prior death changed over time. Methods and results a cohort study covering whole Swedish population, we all who died between 1 July 2007 31 December 2020 for evidence‐based treatments. The proportion on respective time was examined by year using binomial regression. Looking back time, discontinuation rates were estimated Poisson...

Abstract Aims This study aimed to characterize a contemporary population with subtypes of incident or prevalent heart failure (HF) based on reduced (HFrEF), mildly reduced, preserved (HFpEF) left ventricular ejection fraction (LVEF) and assess how outcomes, healthcare, treatments, healthcare costs vary between each subtype HF. Methods results Using Swedish data from the CardioRenal Metabolic disease Heart Failure ( CaReMe HF ) study, updated cover more recent time period, this...

Abstract Background Potassium binders mitigate hyperkalemia, allowing patients to maintain their renin-angiotensin-aldosterone-system inhibitor (RAASi) treatment. This study characterized treated with first- or second-generation potassium binders, usage patterns and effectiveness in reducing levels, changes RAASi treatment a Swedish population-based study. Methods A National Cohort included who had record of episode first-generation binder between 2018 2022. Mid-Sweden from the also...

Abstract FRAX is a tool that identifies individuals with high fracture risk who will benefit from pharmacological treatment of osteoporosis. However, majority fractures among elderly occur in people without osteoporosis and most after fall. Our aim was to accurately identify men future fracture, independent cause. In the population-based Uppsala Longitudinal Study Adult Men (ULSAM) using survival analysis we studied different models' prognostic values (R2) for any hip within 10 years age 50...

Introduction of the direct-acting antivirals (DAAs) for treatment chronic hepatitis C (CHC) infection has been challenging in all health systems. In Sweden, a national protocol managed introduction was developed. It optional, but county councils agreed to implement and follow it. The purpose this study (a) cure rates among patients initiated on 2014-2015, (b) prescribers' adherence drug recommendations eligibility criteria protocol, (c) rate six Swedish healthcare regions.A cross-sectional...

Objectives Identify the windows of opportunity for diagnosis chronic kidney disease (CKD) and prevention its adverse outcomes quantify potential population gains such prevention. Design setting Observational, population-wide study residents in Stockholm Skåne regions Sweden between 1 January 2015 31 December 2020. Participants All patients who did not yet have a CKD healthcare but had according to laboratory measurements biomarkers available electronic health records. Outcome measures We...

Importance Bipolar disorder (BD) often first appears in adolescence after onset of major depressive (MDD), but diagnosis and treatment are commonly delayed. This delay is a concern because untreated BD associated with adverse long-term outcomes, more recurrent disease course difficult-to-treat illness, suicide attempts deaths. Objective To examine the association age at MDD early transition to subsequent use psychiatric inpatient services as severity indicator. Design, Setting, Participants...

To describe patients initiating dimethyl fumarate (DMF) and measure persistence with DMF, discontinuation, switching in treatment-naïve DMF to from other multiple sclerosis disease-modifying treatments (DMTs).A population-based cohort study of all Stockholm County residents 9 May 2014 until 31 2017. All data were derived a regional database that collects individual-level on healthcare drug utilization residents. The outcomes discontinuation DMTs. Persistence was measured as the number days...

Abstract Objective Major depressive disorder (MDD) is a highly prevalent condition and significant contributor to global disability. The vast majority of MDD handled by primary care, but most real‐life studies on only include data from secondary care. aim this study was therefore estimate the total clinical societal burden incident including all healthcare levels in large well‐defined western European region. Methods Population‐wide observational included Region Stockholm, Sweden's largest...

Crohn's disease [CD] and ulcerative colitis [UC] are chronic diseases associated with a substantial utilisation of healthcare resources. We aimed to estimate the prevalence inflammatory bowel [IBD], CD, UC describe compare drug treatment in CD patients. This was cross-sectional study all patients recorded IBD diagnosis Stockholm County, Sweden. Data on outpatient visits, hospitalisations, surgeries, during 2013 were analysed. A total 13 916 identified, corresponding an overall 0.65% [CD...

Abstract There is limited experience and methods for extractions of drug therapy data from electronic health records ( EHR ) in the hospital setting. We have therefore developed evaluated completeness consistency an automatic versus a semi‐automatic extraction procedure applied on prescribing administration TNF inhibitor infliximab using system K arolinska U niversity H ospital, S weden. Using two different (automatic semi‐automatic), all administered infusions between 2007 2010 were...