A5090727541- Healthcare Systems and Public Health
- Acute Myocardial Infarction Research
- Cardiomyopathy and Myosin Studies
- Atrial Fibrillation Management and Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Oral microbiology and periodontitis research
- Cardiovascular Function and Risk Factors
- Cardiac Health and Mental Health
- Cardiac Valve Diseases and Treatments
- Streptococcal Infections and Treatments
- Lysosomal Storage Disorders Research
- Dental Health and Care Utilization
- Clinical practice guidelines implementation
- Infective Endocarditis Diagnosis and Management
- Pleural and Pulmonary Diseases
- Tracheal and airway disorders
- Genetic Associations and Epidemiology
- Studies on Chitinases and Chitosanases
- TGF-β signaling in diseases
- Lung Cancer Diagnosis and Treatment
- Coronary Interventions and Diagnostics
- Dental Radiography and Imaging
- Cardiac, Anesthesia and Surgical Outcomes
- Interpreting and Communication in Healthcare
- Lipoproteins and Cardiovascular Health
Queen's University Belfast
2012-2024
Belfast Health and Social Care Trust
2019-2023
Royal Victoria Hospital
2015-2022
University of Ulster
2015-2022
Southern Health and Social Care Trust
2020-2022
Craigavon Area Hospital
2019-2020
Ulster Hospital
2014
University of Dundee
2012
To investigate the association between periodontitis and mortality from all causes in a prospective study homogenous group of 60- to 70-year-old West European men.A representative sample 1400 dentate men, (mean age 63.8, SD 3.0 years), drawn population Northern Ireland, had comprehensive periodontal examination 2001 2003. Men were divided into thirds on basis their mean attachment loss (PAL). The primary endpoint, death any cause, was analysed using Kaplan-Meier survival plots Cox's...
To investigate periodontitis as a risk factor for prevalent and incident coronary heart disease (CHD) in group of middle-aged men from Northern Ireland.A representative sample 1400 dentate had comprehensive periodontal examination between 2001 2003. Prevalent CHD events were validated by independent cardiologists. Logistic regression was used to assess the cross-sectional relationship Cox's proportional hazards analysis longitudinal CHD.The mean age at baseline 63.7 (SD 3.0) years. Of...
The aim was to investigate the role of systemic inflammation in relationship between periodontitis, edentulism, and all-cause mortality a group men Northern Ireland aged 58-72 years.A representative sample 1558 had detailed dental examination 2001 2003. primary end point death from any cause. Cox's proportional hazards model used assess longitudinal mortality. Accelerated failure time modelling performed mediating inflammation.Mean age at baseline 64.3 (standard deviation 2.9) years. During...
Background Historically, high levels of morbidity and mortality have been associated with cardiovascular disease in the Northern Ireland population. Previously reported associations between single nucleotide polymorphisms (SNPs) within other populations not always consistent. Objective To investigate 33 SNPs fatal or non-fatal incident coronary heart (CHD) events all-cause Irish participants Prospective Epidemiological Study Myocardial Infarction (PRIME). Method Phase 2 PRIME study...
Hypertrophic cardiomyopathy (HCM) is a disease, which difficult to diagnose at an early stage and for there pressing need more effective treatment options. The purpose of this study was compare the molecular profile HCM that ischaemic (ISCM) dilated (DCM) identification protein pathway targets could support development better diagnostic options HCM. A high-throughput mass spectrometry workflow applied achieve deep quantitative coverage left ventricular tissue from HCM, DCM, ISCM...
<h3>Background</h3> Primary PCI (PPCI) is the preferred treatment for patients presenting with ST-elevation myocardial infarction (STEMI). Strategies to minimise PCI-related delayinclude bringing directly cath lab following ECG transmission. The aim of this study was assess frequency, appropriateness and clinical outcomes turned down PPCI by process. <h3>Methods</h3> Belfast pathway activated CCU nurses according a regionally agreed protocol. Electrocardiograms (ECG) are faxed central hub in...
<h3>Aims</h3> To establish the safety and efficacy of a rapid one hour chest pain pathway using high sensitivity troponin T (HsTnT) to triage patients presenting with cardiac sounding Emergency Departments (ED) in Belfast Health Social Care Trust (BHSCT). <h3>Methods</h3> Recent ESC guidelines support use HsTnT safely "rule out" myocardial infarction (MI) ED suspected pain. After an initial pilot study BHSCT implemented July 2016 incorporating results levels at presentation hour, patient...
<h3>Introduction</h3> Primary PCI (PPCI) is the recommended treatment for patients presenting with ST-elevation myocardial infarction (STEMI). The catheterisation laboratory in Royal Victoria Hospital Belfast activated when a diagnostic STEMI ECG received from an ambulance crew or emergency department. decision to activate taken by CCU nurses. aim of this study was assess numbers, sources, appropriateness and clinical outcomes turned down PPCI process accuracy nurse-delivered interpretation....
<h3>Introduction</h3> We previously reported PCI outcomes in the elderly (age ≥80) over 2 year period 2003–4. Since then unit has introduced routine primary and TAVI. This re-audit assessed impact of these changes on our practice outcomes. <h3>Methods</h3> All patients 2014 were identified using trust database 90 day obtained from Northern Ireland electronic care record. <h3>Results</h3> There 257 PCIs 241 patients; outcome data was available for 239 patients. Demographics, presentation are...
<h3>Introduction</h3> Fabry disease (FD) is a rare multi-system X-linked that under-diagnosed despite availability of screening tests such as blood (alpha-galactosidase A enzyme), urine (GL-3 level) and genetic testing. Cardiac manifestations are the commonest cause mortality. In adults earliest cardiovascular manifestation FD picked up at bedside left ventricular hypertrophy (LVH) [1]. This typically occurs in third-fourth decades life prevalence patients with unexplained LVH 0.5-1% [2,3]....